Deletion Strain | FD score | P-value | Gene | Gene Description |
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YBL008W-A_p | 7.86 | 1.93E-15 | YBL008W-A_p | Putative protein of unknown function; identified by fungal homology and RT-PCR |
YHR050W-A_p | 7.83 | 2.35E-15 | YHR050W-A_p | Protein of unknown function; identified by expression profiling and mass spectrometry |
YGL066W | 6.11 | 4.99E-10 | SGF73 | SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay |
YHR194W | 5.13 | 1.45E-7 | MDM31 | Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34 |
YMR257C | 5.12 | 1.54E-7 | PET111 | Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane |
YKL091C | 5.00 | 2.79E-7 | YKL091C | Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study |
YJL215C_d | 4.95 | 3.68E-7 | YJL215C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YLR092W | 4.90 | 4.89E-7 | SUL2 | High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates |
YAL044C | 4.86 | 5.95E-7 | GCV3 | H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF |
YKL181W | 4.77 | 9.25E-7 | PRS1 | 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes |
YAL037W_p | 4.66 | 1.56E-6 | YAL037W_p | Putative protein of unknown function; YAL037W has a paralog, YOR342C, that arose from the whole genome duplication |
YOR247W | 4.61 | 2.02E-6 | SRL1 | Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication |
YGR212W | 4.59 | 2.22E-6 | SLI1 | N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin |
YKL056C | 4.47 | 3.84E-6 | TMA19 | Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress |
YBL009W | 4.25 | 1.09E-5 | ALK2 | Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins |