Deletion Strain | FD score | P-value | Gene | Gene Description |
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YKL217W | 7.45 | 4.54E-14 | JEN1 | Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose |
YGL057C | 6.11 | 4.86E-10 | GEP7 | Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
YCR045C | 5.63 | 9.10E-9 | RRT12 | Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores |
YGR221C | 5.38 | 3.69E-8 | TOS2 | Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p |
YOR273C | 5.38 | 3.77E-8 | TPO4 | Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane |
YNL081C | 5.08 | 1.86E-7 | SWS2 | Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency |
YBL098W | 5.04 | 2.38E-7 | BNA4 | Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease |
YHR022C-A_p | 5.00 | 2.82E-7 | YHR022C-A_p | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
YOR243C | 4.87 | 5.60E-7 | PUS7 | Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria |
YBR018C | 4.66 | 1.59E-6 | GAL7 | Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism |
YNL160W | 4.61 | 1.99E-6 | YGP1 | Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p |
YHR031C | 4.52 | 3.13E-6 | RRM3 | DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p |
YLR287C_p | 4.50 | 3.38E-6 | YLR287C_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene |
YCL002C_p | 4.40 | 5.40E-6 | YCL002C_p | Putative protein of unknown function; YCL002C is not an essential gene |
YCL014W | 4.31 | 8.15E-6 | BUD3 | Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding |