Deletion Strain | FD score | P-value | Gene | Gene Description |
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YOR162C | 11.00 | 1.15E-28 | YRR1 | Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication |
YPL022W | 8.64 | 2.87E-18 | RAD1 | Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein |
YOR136W | 8.11 | 2.62E-16 | IDH2 | Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated |
YGL012W | 8.05 | 4.23E-16 | ERG4 | C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol |
YMR152W | 7.32 | 1.28E-13 | YIM1 | Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress |
YJL185C | 6.68 | 1.19E-11 | ATG36 | Pex3p interacting protein, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene |
YNL148C | 6.68 | 1.21E-11 | ALF1 | Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance |
YMR090W_p | 5.97 | 1.17E-9 | YMR090W_p | Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability |
YER135C_d | 5.79 | 3.43E-9 | YER135C_d | Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene |
YPL216W_p | 5.79 | 3.60E-9 | YPL216W_p | Putative protein of unknown function; YPL216W is not an essential gene |
YOR118W | 5.67 | 7.11E-9 | RTC5 | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity |
YPL172C | 5.63 | 8.93E-9 | COX10 | Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders |
YOR089C | 5.44 | 2.64E-8 | VPS21 | Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication |
YLR370C | 5.37 | 3.99E-8 | ARC18 | Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches |
YOR253W | 5.33 | 4.96E-8 | NAT5 | Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing |