Deletion Strain | FD score | P-value | Gene | Gene Description |
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YLR169W_d | 12.70 | 3.69E-37 | YLR169W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YJL154C | 10.40 | 1.31E-25 | VPS35 | Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p |
YFL034W_p | 7.64 | 1.05E-14 | YFL034W_p | Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk |
YPL145C | 6.66 | 1.34E-11 | KES1 | One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication |
YHR012W | 6.57 | 2.51E-11 | VPS29 | Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval |
YGL019W | 6.13 | 4.44E-10 | CKB1 | Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases |
YGR122W | 5.98 | 1.15E-9 | YGR122W | Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress |
YML094C-A_d | 5.91 | 1.68E-9 | YML094C-A_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO |
YDR080W | 5.84 | 2.65E-9 | VPS41 | Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport |
YDR378C | 5.83 | 2.74E-9 | LSM6 | Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA |
YLR171W_d | 5.78 | 3.64E-9 | YLR171W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YML007C-A_p | 5.66 | 7.49E-9 | YML007C-A_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria |
YDR455C_d | 5.51 | 1.80E-8 | YDR455C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W |
YJL053W | 5.30 | 5.86E-8 | PEP8 | Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress |
YDL090C | 5.05 | 2.20E-7 | RAM1 | Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit |