Deletion Strain | FD score | P-value | Gene | Gene Description |
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YFR015C | 6.89 | 2.73E-12 | GSY1 | Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress |
YDR127W | 6.79 | 5.80E-12 | ARO1 | Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids |
YMR294W | 6.03 | 8.18E-10 | JNM1 | Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B |
YCL069W | 5.94 | 1.40E-9 | VBA3 | Permease of basic amino acids in the vacuolar membrane |
YGR107W_d | 5.27 | 6.73E-8 | YGR107W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YMR170C | 5.20 | 9.99E-8 | ALD2 | Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p |
YCR003W | 4.90 | 4.82E-7 | MRPL32 | Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress |
YHR134W | 4.61 | 1.99E-6 | WSS1 | Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response |
YPL038W | 4.52 | 3.03E-6 | MET31 | Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication |
YBL029C-A_p | 4.50 | 3.41E-6 | YBL029C-A_p | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica |
YIL123W | 4.35 | 6.83E-6 | SIM1 | Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated |
YMR167W | 4.31 | 8.25E-6 | MLH1 | Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer |
YPR047W | 4.27 | 9.81E-6 | MSF1 | Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase |
YIL067C_p | 4.26 | 1.04E-5 | YIL067C_p | Uncharacterized protein of unknown function |
YPL206C | 4.25 | 1.08E-5 | PGC1 | Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs |