Deletion Strain | FD score | P-value | Gene | Gene Description |
---|
YNR008W | 29.30 | 7.98E-189 | LRO1 | Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase |
YML071C | 8.01 | 5.66E-16 | COG8 | Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments |
YGL005C | 7.14 | 4.61E-13 | COG7 | Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments |
YNL041C | 7.07 | 7.50E-13 | COG6 | Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments |
YNL336W | 5.89 | 1.96E-9 | COS1 | Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins |
YLR171W_d | 5.15 | 1.31E-7 | YLR171W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YOR134W | 4.99 | 3.02E-7 | BAG7 | Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p |
YPL202C | 4.89 | 4.99E-7 | AFT2 | Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication |
YJR059W | 4.87 | 5.46E-7 | PTK2 | Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake |
YLR371W | 4.63 | 1.79E-6 | ROM2 | GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p |
YAR031W | 4.61 | 2.01E-6 | PRM9 | Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family |
YDR017C | 4.59 | 2.17E-6 | KCS1 | Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance |
YLR131C | 4.53 | 2.89E-6 | ACE2 | Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication |
YOL046C_d | 4.51 | 3.26E-6 | YOL046C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data;almost completely overlaps the verified gene PSK2/YOL045W |
YER075C | 4.45 | 4.30E-6 | PTP3 | Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm |