mead acid

(5Z,8Z,11Z)-icosa-5,8,11-trienoic acid

An omega 9 fatty acid.

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_476
Screen concentration 10.0 μM
Source ICCB bioactive library
PubChem CID 5312531
SMILES CCCCCCCCC=CCC=CCC=CCCCC(=O)O
Standardized SMILES CCCCCCCCC=CCC=CCC=CCCCC(=O)O
Molecular weight 306.4828
ALogP 6.88
H-bond donor count 1
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.69
% growth inhibition (Hom. pool) 4.17


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 5312531
Download HIP data (tab-delimited text)  (excel)
Gene:ACS2(YLR153C)|FD-Score:3.11|P-value:9.49E-4|Clearance:0.16||SGD DESC:Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions Gene:ENP1(YBR247C)|FD-Score:3.29|P-value:5.04E-4|Clearance:0.18||SGD DESC:Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus Gene:FOL1(YNL256W)|FD-Score:3.66|P-value:1.27E-4|Clearance:0.37||SGD DESC:Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities Gene:GCD2(YGR083C)|FD-Score:-3.83|P-value:6.34E-5|Clearance:0||SGD DESC:Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression Gene:RPO26(YPR187W)|FD-Score:-3.41|P-value:3.21E-4|Clearance:0||SGD DESC:RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit Gene:SMD3(YLR147C)|FD-Score:4.52|P-value:3.05E-6|Clearance:0.87||SGD DESC:Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3 Gene:ACS2(YLR153C)|FD-Score:3.11|P-value:9.49E-4|Clearance:0.16||SGD DESC:Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions Gene:ENP1(YBR247C)|FD-Score:3.29|P-value:5.04E-4|Clearance:0.18||SGD DESC:Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus Gene:FOL1(YNL256W)|FD-Score:3.66|P-value:1.27E-4|Clearance:0.37||SGD DESC:Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities Gene:GCD2(YGR083C)|FD-Score:-3.83|P-value:6.34E-5|Clearance:0||SGD DESC:Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression Gene:RPO26(YPR187W)|FD-Score:-3.41|P-value:3.21E-4|Clearance:0||SGD DESC:RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit Gene:SMD3(YLR147C)|FD-Score:4.52|P-value:3.05E-6|Clearance:0.87||SGD DESC:Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 5312531
Download HOP data (tab-delimited text)  (excel)
Gene:AAT2(YLR027C)|FD-Score:-3.12|P-value:8.92E-4||SGD DESC:Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells Gene:CAP2(YIL034C)|FD-Score:4.09|P-value:2.19E-5||SGD DESC:Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress Gene:INO2(YDR123C)|FD-Score:3.96|P-value:3.71E-5||SGD DESC:Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion Gene:KAR5(YMR065W)|FD-Score:3.42|P-value:3.15E-4||SGD DESC:Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone Gene:LEU3(YLR451W)|FD-Score:3.1|P-value:9.63E-4||SGD DESC:Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation Gene:MCM16(YPR046W)|FD-Score:3.33|P-value:4.31E-4||SGD DESC:Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3 Gene:MEI4(YER044C-A)|FD-Score:3.25|P-value:5.82E-4||SGD DESC:Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores Gene:MET16(YPR167C)|FD-Score:3.18|P-value:7.28E-4||SGD DESC:3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism Gene:PEX12(YMR026C)|FD-Score:3.43|P-value:2.98E-4||SGD DESC:C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder Gene:PPH22(YDL188C)|FD-Score:-3.67|P-value:1.21E-4||SGD DESC:Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication Gene:SNC1(YAL030W)|FD-Score:3.64|P-value:1.39E-4||SGD DESC:Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication Gene:SNZ2(YNL333W)|FD-Score:3.73|P-value:9.71E-5||SGD DESC:Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p Gene:SOV1(YMR066W)|FD-Score:3.14|P-value:8.59E-4||SGD DESC:Mitochondrial protein of unknown function Gene:ULA1(YPL003W)|FD-Score:-4.51|P-value:3.21E-6||SGD DESC:Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation Gene:VHS1(YDR247W)|FD-Score:3.74|P-value:9.07E-5||SGD DESC:Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p Gene:YDR278C(YDR278C_d)|FD-Score:3.43|P-value:3.01E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YFL051C(YFL051C_p)|FD-Score:-3.28|P-value:5.20E-4||SGD DESC:Putative protein of unknown function; YFL051C is not an essential gene Gene:YGR045C(YGR045C_d)|FD-Score:3.64|P-value:1.37E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YJR128W(YJR128W_d)|FD-Score:3.78|P-value:7.86E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2 Gene:YNR066C(YNR066C_p)|FD-Score:3.09|P-value:9.85E-4||SGD DESC:Putative membrane-localized protein of unknown function Gene:AAT2(YLR027C)|FD-Score:-3.12|P-value:8.92E-4||SGD DESC:Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells Gene:CAP2(YIL034C)|FD-Score:4.09|P-value:2.19E-5||SGD DESC:Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress Gene:INO2(YDR123C)|FD-Score:3.96|P-value:3.71E-5||SGD DESC:Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion Gene:KAR5(YMR065W)|FD-Score:3.42|P-value:3.15E-4||SGD DESC:Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone Gene:LEU3(YLR451W)|FD-Score:3.1|P-value:9.63E-4||SGD DESC:Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation Gene:MCM16(YPR046W)|FD-Score:3.33|P-value:4.31E-4||SGD DESC:Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3 Gene:MEI4(YER044C-A)|FD-Score:3.25|P-value:5.82E-4||SGD DESC:Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores Gene:MET16(YPR167C)|FD-Score:3.18|P-value:7.28E-4||SGD DESC:3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism Gene:PEX12(YMR026C)|FD-Score:3.43|P-value:2.98E-4||SGD DESC:C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder Gene:PPH22(YDL188C)|FD-Score:-3.67|P-value:1.21E-4||SGD DESC:Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication Gene:SNC1(YAL030W)|FD-Score:3.64|P-value:1.39E-4||SGD DESC:Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication Gene:SNZ2(YNL333W)|FD-Score:3.73|P-value:9.71E-5||SGD DESC:Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p Gene:SOV1(YMR066W)|FD-Score:3.14|P-value:8.59E-4||SGD DESC:Mitochondrial protein of unknown function Gene:ULA1(YPL003W)|FD-Score:-4.51|P-value:3.21E-6||SGD DESC:Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation Gene:VHS1(YDR247W)|FD-Score:3.74|P-value:9.07E-5||SGD DESC:Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p Gene:YDR278C(YDR278C_d)|FD-Score:3.43|P-value:3.01E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YFL051C(YFL051C_p)|FD-Score:-3.28|P-value:5.20E-4||SGD DESC:Putative protein of unknown function; YFL051C is not an essential gene Gene:YGR045C(YGR045C_d)|FD-Score:3.64|P-value:1.37E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YJR128W(YJR128W_d)|FD-Score:3.78|P-value:7.86E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2 Gene:YNR066C(YNR066C_p)|FD-Score:3.09|P-value:9.85E-4||SGD DESC:Putative membrane-localized protein of unknown function

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YLR147C4.523.05E-60.87SMD3Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3
YNL256W3.661.27E-40.37FOL1Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities
YBR247C3.295.04E-40.18ENP1Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus
YLR153C3.119.49E-40.16ACS2Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
YFR028C2.950.001610.19CDC14Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis
YLR277C2.760.002920.02YSH1Putative endoribonuclease; subunit of the mRNA cleavage and polyadenylation specificity complex; required for 3' processing, splicing, and transcriptional termination of mRNAs and snoRNAs; protein abundance increases in response to DNA replication stress; YSH1 has a paralog, SYC1, that arose from the whole genome duplication
YDR087C2.740.003080.01RRP1Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles
YMR301C2.730.003163.28E-4ATM1Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol
YIL031W2.730.003170.17ULP2Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate
YGR265W_d2.560.005290.00YGR265W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
YGR246C2.550.005320.04BRF1TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB
YLR140W_d2.510.005970.01YLR140W_dDubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I
YMR134W_p2.510.006060.06ERG29_pProtein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
YGL112C2.450.007150.02TAF6Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
YGR211W2.420.007660.03ZPR1Essential protein with two zinc fingers; present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p); relative distribution to the nucleus increases upon DNA replication stress

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YIL034C4.092.19E-5CAP2Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress
YDR123C3.963.71E-5INO2Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion
YJR128W_d3.787.86E-5YJR128W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
YDR247W3.749.07E-5VHS1Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
YNL333W3.739.71E-5SNZ2Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p
YGR045C_d3.641.37E-4YGR045C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAL030W3.641.39E-4SNC1Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication
YMR026C3.432.98E-4PEX12C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder
YDR278C_d3.433.01E-4YDR278C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR065W3.423.15E-4KAR5Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone
YPR046W3.334.31E-4MCM16Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3
YER044C-A3.255.82E-4MEI4Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores
YPR167C3.187.28E-4MET163'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism
YMR066W3.148.59E-4SOV1Mitochondrial protein of unknown function
YLR451W3.109.63E-4LEU3Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation

GO enrichment analysis for SGTC_476
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0791.12E-9SGTC_28949048625 32.5 μMChembridge (Drug-like library)40928610.0833333
0.0715.53E-8SGTC_25623',7'-dimethoxyflavone 64.9 μMMicrosource (Natural product library)6886640.0327869
0.0664.25E-7SGTC_13441488-0097 29.1 μMChemDiv (Drug-like library)7479660.0163934
0.0552.65E-5SGTC_3174495-0002 170.0 μMChemDiv (Drug-like library)159916180.0634921
0.0542.85E-5SGTC_12620737-0114 49.6 μMChemDiv (Drug-like library)7659190.125
0.0534.69E-5SGTC_484loperamide 105.0 μMMiscellaneous39550.0869565
0.0535.38E-5SGTC_14524194-0072 190.0 μMChemDiv (Drug-like library)13435450.0533333
0.0517.75E-5SGTC_1906st060206 94.7 μMTimTec (Natural product derivative library)51334680.0526316
0.0518.05E-5SGTC_22957971645 200.0 μMChembridge (Fragment library)29782260.0769231
0.0491.45E-4SGTC_1753st043925 64.0 μMTimTec (Natural product derivative library)6701810.0606061
0.0491.55E-4SGTC_25534-methylesculetin 85.1 μMMicrosource (Natural product library)53195020.06
0.0491.55E-4SGTC_32299132204 49.5 μMChembridge (Drug-like library)176829240.0666667
0.0463.83E-4SGTC_11523909-8331 15.9 μMChemDiv (Drug-like library)160019390.0289855
0.0464.44E-4SGTC_1560lithocholic acid 53.1 μMTimTec (Pure natural product library)99030.15873
0.0455.07E-4SGTC_1465k213-0056 144.0 μMChemDiv (Drug-like library)240488570.0597015DNA intercalators

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_409arachidonic acid100 μM0.962963231Miscellaneous304.466886.43912
SGTC_410α-linolenic acid100 μM0.741935860Miscellaneous278.42965.97112excess fatty acid
SGTC_475α-linolenic acid10 μM0.7419355280934ICCB bioactive library278.42965.97112excess fatty acid
SGTC_478N-arachidonylglycine10 μM0.6666675283389ICCB bioactive library361.51825.49923
SGTC_479n-linoleoylglycine10 μM0.6486496433346ICCB bioactive library337.49685.47623
SGTC_477mead ethanolamide10 μM0.60526316061185ICCB bioactive library349.550565.92222
SGTC_4732-arachidonoylglycerol10 μM0.5641035282280ICCB bioactive library378.545425.61424
SGTC_1617st00290678 μM0.531255150859TimTec (Natural product derivative library)256.381024.51413
SGTC_1616st00273456.1 μM0.4722224026101TimTec (Natural product derivative library)356.53997.40224
SGTC_1573oleylamine1.06 μM0.43755356789TimTec (Pure natural product library)267.493086.62311
SGTC_1876myriocin605 nM0.4301119Miscellaneous401.537460.28457