n-linoleoylglycine

2-[[(9Z,12Z)-octadeca-9,12-dienoyl]amino]acetic acid

An anti-infammatory.

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_479
Screen concentration 10.0 μM
Source ICCB bioactive library
PubChem CID 6433346
SMILES CCCCCC=CCC=CCCCCCCCC(=O)NCC(=O)O
Standardized SMILES CCCCCC=CCC=CCCCCCCCC(=O)NCC(=O)O
Molecular weight 337.4968
ALogP 5.48
H-bond donor count 2
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 0.34
% growth inhibition (Hom. pool) 2.77


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 6433346
Download HIP data (tab-delimited text)  (excel)
Gene:CDC14(YFR028C)|FD-Score:3.36|P-value:3.84E-4|Clearance:0.01||SGD DESC:Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis Gene:DPM1(YPR183W)|FD-Score:-3.74|P-value:9.21E-5|Clearance:0||SGD DESC:Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation Gene:RRP7(YCL031C)|FD-Score:3.21|P-value:6.57E-4|Clearance:0.06||SGD DESC:Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress Gene:SQT1(YIR012W)|FD-Score:3.15|P-value:8.21E-4|Clearance:0.06||SGD DESC:Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress Gene:YGL102C(YGL102C_d)|FD-Score:3.36|P-value:3.94E-4|Clearance:0.14||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein Gene:YLR140W(YLR140W_d)|FD-Score:3.9|P-value:4.88E-5|Clearance:0.53||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I Gene:CDC14(YFR028C)|FD-Score:3.36|P-value:3.84E-4|Clearance:0.01||SGD DESC:Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis Gene:DPM1(YPR183W)|FD-Score:-3.74|P-value:9.21E-5|Clearance:0||SGD DESC:Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation Gene:RRP7(YCL031C)|FD-Score:3.21|P-value:6.57E-4|Clearance:0.06||SGD DESC:Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress Gene:SQT1(YIR012W)|FD-Score:3.15|P-value:8.21E-4|Clearance:0.06||SGD DESC:Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress Gene:YGL102C(YGL102C_d)|FD-Score:3.36|P-value:3.94E-4|Clearance:0.14||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein Gene:YLR140W(YLR140W_d)|FD-Score:3.9|P-value:4.88E-5|Clearance:0.53||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 6433346
Download HOP data (tab-delimited text)  (excel)
Gene:AFG1(YEL052W)|FD-Score:-4.3|P-value:8.55E-6||SGD DESC:Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain Gene:AIM3(YBR108W)|FD-Score:3.23|P-value:6.18E-4||SGD DESC:Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss Gene:ARC18(YLR370C)|FD-Score:-4.22|P-value:1.21E-5||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Gene:ATG21(YPL100W)|FD-Score:3.65|P-value:1.32E-4||SGD DESC:Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein Gene:ATG3(YNR007C)|FD-Score:6.17|P-value:3.37E-10||SGD DESC:E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p is regulated by its acetylation by Esa1p (catalytic subunit of NuA4 histone acetyltransferase complex) while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p Gene:BDF1(YLR399C)|FD-Score:3.09|P-value:9.85E-4||SGD DESC:Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p Gene:BOP3(YNL042W)|FD-Score:5.43|P-value:2.77E-8||SGD DESC:Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury Gene:BTS1(YPL069C)|FD-Score:-3.79|P-value:7.46E-5||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:CIT1(YNR001C)|FD-Score:3.17|P-value:7.64E-4||SGD DESC:Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication Gene:CPS1(YJL172W)|FD-Score:3.16|P-value:8.01E-4||SGD DESC:Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions Gene:CTS1(YLR286C)|FD-Score:-3.38|P-value:3.65E-4||SGD DESC:Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p Gene:DAL3(YIR032C)|FD-Score:3.56|P-value:1.88E-4||SGD DESC:Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression Gene:DIN7(YDR263C)|FD-Score:-3.84|P-value:6.14E-5||SGD DESC:Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination Gene:EBS1(YDR206W)|FD-Score:3.26|P-value:5.61E-4||SGD DESC:Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors Gene:ENV10(YLR065C)|FD-Score:3.27|P-value:5.38E-4||SGD DESC:Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene Gene:ESC2(YDR363W)|FD-Score:4.92|P-value:4.43E-7||SGD DESC:Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member Gene:FYV6(YNL133C)|FD-Score:-4.21|P-value:1.28E-5||SGD DESC:Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining Gene:GSY1(YFR015C)|FD-Score:3.26|P-value:5.52E-4||SGD DESC:Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:INO2(YDR123C)|FD-Score:-3.44|P-value:2.93E-4||SGD DESC:Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion Gene:IRE1(YHR079C)|FD-Score:4.3|P-value:8.37E-6||SGD DESC:Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress Gene:KIP2(YPL155C)|FD-Score:3.78|P-value:7.91E-5||SGD DESC:Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle Gene:MCH2(YKL221W)|FD-Score:3.67|P-value:1.23E-4||SGD DESC:Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport Gene:MCM16(YPR046W)|FD-Score:4.89|P-value:4.94E-7||SGD DESC:Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3 Gene:MLC2(YPR188C)|FD-Score:4.22|P-value:1.20E-5||SGD DESC:Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring Gene:MMS4(YBR098W)|FD-Score:-3.78|P-value:7.76E-5||SGD DESC:Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p Gene:PAU7(YAR020C)|FD-Score:3.1|P-value:9.72E-4||SGD DESC:Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme Gene:ROD1(YOR018W)|FD-Score:4.9|P-value:4.75E-7||SGD DESC:Membrane protein, binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene, zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication Gene:RPB9(YGL070C)|FD-Score:-4.43|P-value:4.73E-6||SGD DESC:RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription Gene:RPS14B(YJL191W)|FD-Score:4.33|P-value:7.41E-6||SGD DESC:Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog, RPS14A, that arose from the whole genome duplication Gene:SAL1(YNL083W)|FD-Score:3.48|P-value:2.52E-4||SGD DESC:ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains Gene:SHU1(YHL006C)|FD-Score:3.23|P-value:6.22E-4||SGD DESC:Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function Gene:SRN2(YLR119W)|FD-Score:-3.1|P-value:9.73E-4||SGD DESC:Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus Gene:SSA4(YER103W)|FD-Score:3.6|P-value:1.56E-4||SGD DESC:Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; SSA4 has a paralog, SSA3, that arose from the whole genome duplication Gene:TAZ1(YPR140W)|FD-Score:-3.18|P-value:7.38E-4||SGD DESC:Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome Gene:TRP3(YKL211C)|FD-Score:3.68|P-value:1.17E-4||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:YDR061W(YDR061W_p)|FD-Score:3.53|P-value:2.05E-4||SGD DESC:Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance Gene:YFL019C(YFL019C_d)|FD-Score:4.09|P-value:2.12E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene Gene:YMR122C(YMR122C_d)|FD-Score:3.74|P-value:9.21E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNL095C(YNL095C_p)|FD-Score:4.02|P-value:2.87E-5||SGD DESC:Putative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication Gene:YNR064C(YNR064C)|FD-Score:3.19|P-value:7.09E-4||SGD DESC:Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides Gene:YOR020W-A(YOR020W-A_p)|FD-Score:-3.17|P-value:7.61E-4||SGD DESC:Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YPR097W(YPR097W)|FD-Score:3.12|P-value:8.97E-4||SGD DESC:Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:AFG1(YEL052W)|FD-Score:-4.3|P-value:8.55E-6||SGD DESC:Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain Gene:AIM3(YBR108W)|FD-Score:3.23|P-value:6.18E-4||SGD DESC:Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss Gene:ARC18(YLR370C)|FD-Score:-4.22|P-value:1.21E-5||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Gene:ATG21(YPL100W)|FD-Score:3.65|P-value:1.32E-4||SGD DESC:Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein Gene:ATG3(YNR007C)|FD-Score:6.17|P-value:3.37E-10||SGD DESC:E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p is regulated by its acetylation by Esa1p (catalytic subunit of NuA4 histone acetyltransferase complex) while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p Gene:BDF1(YLR399C)|FD-Score:3.09|P-value:9.85E-4||SGD DESC:Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p Gene:BOP3(YNL042W)|FD-Score:5.43|P-value:2.77E-8||SGD DESC:Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury Gene:BTS1(YPL069C)|FD-Score:-3.79|P-value:7.46E-5||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:CIT1(YNR001C)|FD-Score:3.17|P-value:7.64E-4||SGD DESC:Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication Gene:CPS1(YJL172W)|FD-Score:3.16|P-value:8.01E-4||SGD DESC:Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions Gene:CTS1(YLR286C)|FD-Score:-3.38|P-value:3.65E-4||SGD DESC:Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p Gene:DAL3(YIR032C)|FD-Score:3.56|P-value:1.88E-4||SGD DESC:Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression Gene:DIN7(YDR263C)|FD-Score:-3.84|P-value:6.14E-5||SGD DESC:Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination Gene:EBS1(YDR206W)|FD-Score:3.26|P-value:5.61E-4||SGD DESC:Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors Gene:ENV10(YLR065C)|FD-Score:3.27|P-value:5.38E-4||SGD DESC:Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene Gene:ESC2(YDR363W)|FD-Score:4.92|P-value:4.43E-7||SGD DESC:Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member Gene:FYV6(YNL133C)|FD-Score:-4.21|P-value:1.28E-5||SGD DESC:Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining Gene:GSY1(YFR015C)|FD-Score:3.26|P-value:5.52E-4||SGD DESC:Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:INO2(YDR123C)|FD-Score:-3.44|P-value:2.93E-4||SGD DESC:Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion Gene:IRE1(YHR079C)|FD-Score:4.3|P-value:8.37E-6||SGD DESC:Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress Gene:KIP2(YPL155C)|FD-Score:3.78|P-value:7.91E-5||SGD DESC:Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle Gene:MCH2(YKL221W)|FD-Score:3.67|P-value:1.23E-4||SGD DESC:Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport Gene:MCM16(YPR046W)|FD-Score:4.89|P-value:4.94E-7||SGD DESC:Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3 Gene:MLC2(YPR188C)|FD-Score:4.22|P-value:1.20E-5||SGD DESC:Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring Gene:MMS4(YBR098W)|FD-Score:-3.78|P-value:7.76E-5||SGD DESC:Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p Gene:PAU7(YAR020C)|FD-Score:3.1|P-value:9.72E-4||SGD DESC:Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme Gene:ROD1(YOR018W)|FD-Score:4.9|P-value:4.75E-7||SGD DESC:Membrane protein, binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene, zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication Gene:RPB9(YGL070C)|FD-Score:-4.43|P-value:4.73E-6||SGD DESC:RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription Gene:RPS14B(YJL191W)|FD-Score:4.33|P-value:7.41E-6||SGD DESC:Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog, RPS14A, that arose from the whole genome duplication Gene:SAL1(YNL083W)|FD-Score:3.48|P-value:2.52E-4||SGD DESC:ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains Gene:SHU1(YHL006C)|FD-Score:3.23|P-value:6.22E-4||SGD DESC:Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function Gene:SRN2(YLR119W)|FD-Score:-3.1|P-value:9.73E-4||SGD DESC:Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus Gene:SSA4(YER103W)|FD-Score:3.6|P-value:1.56E-4||SGD DESC:Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; SSA4 has a paralog, SSA3, that arose from the whole genome duplication Gene:TAZ1(YPR140W)|FD-Score:-3.18|P-value:7.38E-4||SGD DESC:Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome Gene:TRP3(YKL211C)|FD-Score:3.68|P-value:1.17E-4||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:YDR061W(YDR061W_p)|FD-Score:3.53|P-value:2.05E-4||SGD DESC:Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance Gene:YFL019C(YFL019C_d)|FD-Score:4.09|P-value:2.12E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene Gene:YMR122C(YMR122C_d)|FD-Score:3.74|P-value:9.21E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNL095C(YNL095C_p)|FD-Score:4.02|P-value:2.87E-5||SGD DESC:Putative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication Gene:YNR064C(YNR064C)|FD-Score:3.19|P-value:7.09E-4||SGD DESC:Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides Gene:YOR020W-A(YOR020W-A_p)|FD-Score:-3.17|P-value:7.61E-4||SGD DESC:Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YPR097W(YPR097W)|FD-Score:3.12|P-value:8.97E-4||SGD DESC:Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YLR140W_d3.904.88E-50.53YLR140W_dDubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I
YFR028C3.363.84E-40.01CDC14Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis
YGL102C_d3.363.94E-40.14YGL102C_dDubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein
YCL031C3.216.57E-40.06RRP7Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress
YIR012W3.158.21E-40.06SQT1Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
YBR140C3.090.001020.03IRA1GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication
YGR277C3.050.001130.06CAB4Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved
YPL146C2.990.001390.01NOP53Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired
YEL002C2.980.001420.07WBP1Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum
YNL113W2.920.001760.02RPC19RNA polymerase subunit AC19, common to RNA polymerases I and III
YDR311W2.900.001870.07TFB1Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators
YLR459W2.830.002310.07GAB1GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI
YKR025W2.760.002850.08RPC37RNA polymerase III subunit C37
YOR174W2.690.003610.04MED4Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YPR177C_d2.640.004120.07YPR177C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YNR007C6.173.37E-10ATG3E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p is regulated by its acetylation by Esa1p (catalytic subunit of NuA4 histone acetyltransferase complex) while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p
YNL042W5.432.77E-8BOP3Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury
YDR363W4.924.43E-7ESC2Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member
YOR018W4.904.75E-7ROD1Membrane protein, binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene, zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication
YPR046W4.894.94E-7MCM16Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3
YJL191W4.337.41E-6RPS14BProtein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog, RPS14A, that arose from the whole genome duplication
YHR079C4.308.37E-6IRE1Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
YPR188C4.221.20E-5MLC2Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring
YFL019C_d4.092.12E-5YFL019C_dDubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YNL095C_p4.022.87E-5YNL095C_pPutative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication
YPL155C3.787.91E-5KIP2Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle
YMR122C_d3.749.21E-5YMR122C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL211C3.681.17E-4TRP3Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
YKL221W3.671.23E-4MCH2Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YPL100W3.651.32E-4ATG21Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein

GO enrichment analysis for SGTC_479
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1019.06E-15SGTC_484loperamide 105.0 μMMiscellaneous39550.0789474
0.0913.05E-12SGTC_5313788-1495 174.0 μMChemDiv (Drug-like library)28966550.101449unfolded protein response
0.0903.89E-12SGTC_22246650123 117.6 μMChembridge (Fragment library)29083700.056338
0.0815.39E-10SGTC_2409alverine citrate 64.0 μMMiscellaneous217180.0754717
0.0809.09E-10SGTC_1617st002906 78.0 μMTimTec (Natural product derivative library)51508590.4
0.0766.00E-9SGTC_468gf-109203x 121.0 μMICCB bioactive library23960.0506329amide catabolism
0.0757.40E-9SGTC_15412',3',6-trimethoxyflavone 64.0 μMTimTec (Pure natural product library)6888010.0277778
0.0758.13E-9SGTC_1117retinoic acid 1.1 μMTimTec (Natural product library)4447950.102941
0.0672.54E-7SGTC_11931488-0126 41.5 μMChemDiv (Drug-like library)13847100.0138889
0.0654.98E-7SGTC_22037227154 166.4 μMChembridge (Fragment library)8963040.0677966
0.0655.63E-7SGTC_30059076496 71.4 μMChembridge (Drug-like library)213684100.0757576
0.0655.74E-7SGTC_15465-methoxyflavanone 78.7 μMTimTec (Pure natural product library)1477950.0294118
0.0655.93E-7SGTC_1673st016611 27.3 μMTimTec (Natural product derivative library)52267990.025641
0.0647.24E-7SGTC_31389097216 49.5 μMChembridge (Drug-like library)252374860.0714286
0.0647.37E-7SGTC_1998st075797 76.8 μMTimTec (Natural product derivative library)242083150.102941mitochondrial response to ROS

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_478N-arachidonylglycine10 μM0.9142865283389ICCB bioactive library361.51825.49923
SGTC_477mead ethanolamide10 μM0.65853716061185ICCB bioactive library349.550565.92222
SGTC_476mead acid10 μM0.6486495312531ICCB bioactive library306.482766.88312
SGTC_409arachidonic acid100 μM0.621622231Miscellaneous304.466886.43912
SGTC_410α-linolenic acid100 μM0.564103860Miscellaneous278.42965.97112excess fatty acid
SGTC_475α-linolenic acid10 μM0.5641035280934ICCB bioactive library278.42965.97112excess fatty acid
SGTC_4732-arachidonoylglycerol10 μM0.4468095282280ICCB bioactive library378.545425.61424
SGTC_1617st00290678 μM0.45150859TimTec (Natural product derivative library)256.381024.51413
SGTC_1876myriocin605 nM0.375301119Miscellaneous401.537460.28457
SGTC_1616st00273456.1 μM0.3636364026101TimTec (Natural product derivative library)356.53997.40224
SGTC_1573oleylamine1.06 μM0.3589745356789TimTec (Pure natural product library)267.493086.62311