Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YBL092W | 5.44 | 2.60E-8 | 1.21 | RPL32 | Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog |
YPR086W | 4.24 | 1.14E-5 | 0.26 | SUA7 | Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II |
YBR190W_d | 3.98 | 3.47E-5 | 9.12E-4 | YBR190W_d | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W |
YFR037C | 3.98 | 3.49E-5 | 0.01 | RSC8 | Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters |
YPL007C | 3.97 | 3.64E-5 | 0.01 | TFC8 | One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90 |
YNR043W | 3.96 | 3.79E-5 | 0.07 | MVD1 | Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer |
YLR208W | 3.89 | 5.09E-5 | 0.14 | SEC13 | Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress |
YPR187W | 3.75 | 8.80E-5 | 0.01 | RPO26 | RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit |
YDL212W | 3.74 | 9.25E-5 | 0.05 | SHR3 | Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface |
YNL247W | 3.69 | 1.13E-4 | 0.01 | YNL247W | Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments |
YPR182W | 3.68 | 1.16E-4 | 0.02 | SMX3 | Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F |
YOR373W | 3.66 | 1.27E-4 | 0.17 | NUD1 | Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance |
YJR046W | 3.49 | 2.46E-4 | 0.10 | TAH11 | DNA replication licensing factor, required for pre-replication complex assembly |
YLR440C | 3.39 | 3.51E-4 | 0.06 | SEC39 | Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope |
YDR311W | 3.33 | 4.32E-4 | 0.14 | TFB1 | Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators |