Deletion Strain | FD score | P-value | Gene | Gene Description |
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YMR202W | 10.30 | 4.67E-25 | ERG2 | C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis |
YBR058C-A | 9.36 | 4.08E-21 | TSC3 | Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis |
YLR262C | 8.07 | 3.38E-16 | YPT6 | Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 |
YDR129C | 6.95 | 1.77E-12 | SAC6 | Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress |
YGL012W | 6.76 | 6.74E-12 | ERG4 | C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol |
YLR338W_d | 6.30 | 1.49E-10 | OPI9_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C |
YKR097W | 6.16 | 3.59E-10 | PCK1 | Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol |
YDL041W_d | 5.83 | 2.76E-9 | YDL041W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C |
YGR249W | 5.81 | 3.20E-9 | MGA1 | Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants |
YDR137W | 5.73 | 5.17E-9 | RGP1 | Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p |
YJR059W | 5.46 | 2.34E-8 | PTK2 | Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake |
YDR028C | 5.28 | 6.63E-8 | REG1 | Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p |
YKL126W | 5.11 | 1.61E-7 | YPK1 | Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication |
YKR019C | 5.07 | 2.00E-7 | IRS4 | EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication |
YGR261C | 5.04 | 2.33E-7 | APL6 | Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools |