niflumic acid FDA approved compound

2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid

A COX2 inhibitor.

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 

PubChem MeSH terms: Anti-Inflammatory Agents, Non-Steroidal;Cyclooxygenase Inhibitors



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_485
Screen concentration 177.0 μM
Source Miscellaneous
PubChem CID 4488
SMILES C1=CC(=CC(=C1)NC2=C(C=CC=N2)C(=O)O)C(F)(F)F
Standardized SMILES OC(=O)c1cccnc1Nc2cccc(c2)C(F)(F)F
Molecular weight 282.218
ALogP 3.34
H-bond donor count 2
H-bond acceptor count 7
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 10.23
% growth inhibition (Hom. pool) 1.55


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 4488
Download HIP data (tab-delimited text)  (excel)
Gene:CCT4(YDL143W)|FD-Score:3.54|P-value:2.03E-4|Clearance:0.2||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:CSL4(YNL232W)|FD-Score:3.22|P-value:6.52E-4|Clearance:0.2||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1) Gene:EMW1(YNL313C)|FD-Score:3.83|P-value:6.31E-5|Clearance:0.2||SGD DESC:Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress Gene:ERG26(YGL001C)|FD-Score:3.51|P-value:2.27E-4|Clearance:0.2||SGD DESC:C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis Gene:NOC2(YOR206W)|FD-Score:3.47|P-value:2.61E-4|Clearance:0.2||SGD DESC:Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors Gene:NUP49(YGL172W)|FD-Score:3.81|P-value:7.06E-5|Clearance:0.2||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p) Gene:RIO2(YNL207W)|FD-Score:3.14|P-value:8.33E-4|Clearance:0.2||SGD DESC:Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p Gene:RTP1(YMR185W_p)|FD-Score:3.62|P-value:1.45E-4|Clearance:0.2||SGD DESC:Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene Gene:YNL114C(YNL114C_d)|FD-Score:3.3|P-value:4.87E-4|Clearance:0.2||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit Gene:CCT4(YDL143W)|FD-Score:3.54|P-value:2.03E-4|Clearance:0.2||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:CSL4(YNL232W)|FD-Score:3.22|P-value:6.52E-4|Clearance:0.2||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1) Gene:EMW1(YNL313C)|FD-Score:3.83|P-value:6.31E-5|Clearance:0.2||SGD DESC:Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress Gene:ERG26(YGL001C)|FD-Score:3.51|P-value:2.27E-4|Clearance:0.2||SGD DESC:C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis Gene:NOC2(YOR206W)|FD-Score:3.47|P-value:2.61E-4|Clearance:0.2||SGD DESC:Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors Gene:NUP49(YGL172W)|FD-Score:3.81|P-value:7.06E-5|Clearance:0.2||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p) Gene:RIO2(YNL207W)|FD-Score:3.14|P-value:8.33E-4|Clearance:0.2||SGD DESC:Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p Gene:RTP1(YMR185W_p)|FD-Score:3.62|P-value:1.45E-4|Clearance:0.2||SGD DESC:Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene Gene:YNL114C(YNL114C_d)|FD-Score:3.3|P-value:4.87E-4|Clearance:0.2||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 4488
Download HOP data (tab-delimited text)  (excel)
Gene:ARP1(YHR129C)|FD-Score:3.23|P-value:6.26E-4||SGD DESC:Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin Gene:ATG7(YHR171W)|FD-Score:3.4|P-value:3.36E-4||SGD DESC:Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation Gene:BSC2(YDR275W)|FD-Score:3.24|P-value:5.96E-4||SGD DESC:Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication Gene:CPR3(YML078W)|FD-Score:4.04|P-value:2.70E-5||SGD DESC:Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria Gene:CTS1(YLR286C)|FD-Score:3.2|P-value:6.88E-4||SGD DESC:Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p Gene:DIN7(YDR263C)|FD-Score:3.15|P-value:8.11E-4||SGD DESC:Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination Gene:FLO1(YAR050W)|FD-Score:3.94|P-value:4.10E-5||SGD DESC:Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p Gene:FPR2(YDR519W)|FD-Score:3.14|P-value:8.43E-4||SGD DESC:Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress Gene:HHF1(YBR009C)|FD-Score:3.98|P-value:3.41E-5||SGD DESC:Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity Gene:JJJ3(YJR097W)|FD-Score:3.34|P-value:4.15E-4||SGD DESC:Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4 Gene:KRE1(YNL322C)|FD-Score:3.73|P-value:9.73E-5||SGD DESC:Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor Gene:MDR1(YGR100W)|FD-Score:-3.36|P-value:3.87E-4||SGD DESC:Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function Gene:MET17(YLR303W)|FD-Score:3.69|P-value:1.13E-4||SGD DESC:Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis Gene:MPD1(YOR288C)|FD-Score:3.51|P-value:2.20E-4||SGD DESC:Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation Gene:MTM1(YGR257C)|FD-Score:4.04|P-value:2.62E-5||SGD DESC:Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor Gene:OTU2(YHL013C)|FD-Score:4.55|P-value:2.65E-6||SGD DESC:Protein of unknown function; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress Gene:PAC10(YGR078C)|FD-Score:3.39|P-value:3.53E-4||SGD DESC:Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding Gene:PIH1(YHR034C)|FD-Score:-3.47|P-value:2.61E-4||SGD DESC:Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II Gene:POF1(YCL047C)|FD-Score:3.27|P-value:5.32E-4||SGD DESC:ATPase involved in the protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion; also interacts with Ubc7p Gene:PRM8(YGL053W)|FD-Score:3.13|P-value:8.76E-4||SGD DESC:Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family Gene:RAM1(YDL090C)|FD-Score:4.78|P-value:8.87E-7||SGD DESC:Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit Gene:TRM3(YDL112W)|FD-Score:3.96|P-value:3.70E-5||SGD DESC:2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs Gene:TVP18(YMR071C)|FD-Score:3.39|P-value:3.44E-4||SGD DESC:Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments Gene:YDR061W(YDR061W_p)|FD-Score:-3.12|P-value:8.92E-4||SGD DESC:Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance Gene:YDR161W(YDR161W_p)|FD-Score:4.91|P-value:4.63E-7||SGD DESC:Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD) Gene:YFR018C(YFR018C_p)|FD-Score:-3.12|P-value:9.10E-4||SGD DESC:Putative protein of unknown function Gene:YFR020W(YFR020W_p)|FD-Score:-4.13|P-value:1.80E-5||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YJR124C(YJR124C_p)|FD-Score:3.31|P-value:4.70E-4||SGD DESC:Putative protein of unknown function; expression induced under calcium shortage Gene:YLR202C(YLR202C_d)|FD-Score:6.78|P-value:5.82E-12||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron Gene:YLR285C-A(YLR285C-A_p)|FD-Score:-3.26|P-value:5.57E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YMR099C(YMR099C)|FD-Score:3.55|P-value:1.95E-4||SGD DESC:Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS Gene:YOR248W(YOR248W_d)|FD-Score:3.57|P-value:1.81E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPR039W(YPR039W_d)|FD-Score:4.1|P-value:2.02E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W Gene:YPR114W(YPR114W_p)|FD-Score:4.73|P-value:1.13E-6||SGD DESC:Putative protein of unknown function Gene:YPT6(YLR262C)|FD-Score:4.02|P-value:2.94E-5||SGD DESC:Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 Gene:YSC83(YHR017W)|FD-Score:3.53|P-value:2.10E-4||SGD DESC:Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83 Gene:ARP1(YHR129C)|FD-Score:3.23|P-value:6.26E-4||SGD DESC:Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin Gene:ATG7(YHR171W)|FD-Score:3.4|P-value:3.36E-4||SGD DESC:Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation Gene:BSC2(YDR275W)|FD-Score:3.24|P-value:5.96E-4||SGD DESC:Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication Gene:CPR3(YML078W)|FD-Score:4.04|P-value:2.70E-5||SGD DESC:Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria Gene:CTS1(YLR286C)|FD-Score:3.2|P-value:6.88E-4||SGD DESC:Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p Gene:DIN7(YDR263C)|FD-Score:3.15|P-value:8.11E-4||SGD DESC:Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination Gene:FLO1(YAR050W)|FD-Score:3.94|P-value:4.10E-5||SGD DESC:Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p Gene:FPR2(YDR519W)|FD-Score:3.14|P-value:8.43E-4||SGD DESC:Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress Gene:HHF1(YBR009C)|FD-Score:3.98|P-value:3.41E-5||SGD DESC:Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity Gene:JJJ3(YJR097W)|FD-Score:3.34|P-value:4.15E-4||SGD DESC:Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4 Gene:KRE1(YNL322C)|FD-Score:3.73|P-value:9.73E-5||SGD DESC:Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor Gene:MDR1(YGR100W)|FD-Score:-3.36|P-value:3.87E-4||SGD DESC:Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function Gene:MET17(YLR303W)|FD-Score:3.69|P-value:1.13E-4||SGD DESC:Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis Gene:MPD1(YOR288C)|FD-Score:3.51|P-value:2.20E-4||SGD DESC:Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation Gene:MTM1(YGR257C)|FD-Score:4.04|P-value:2.62E-5||SGD DESC:Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor Gene:OTU2(YHL013C)|FD-Score:4.55|P-value:2.65E-6||SGD DESC:Protein of unknown function; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress Gene:PAC10(YGR078C)|FD-Score:3.39|P-value:3.53E-4||SGD DESC:Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding Gene:PIH1(YHR034C)|FD-Score:-3.47|P-value:2.61E-4||SGD DESC:Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II Gene:POF1(YCL047C)|FD-Score:3.27|P-value:5.32E-4||SGD DESC:ATPase involved in the protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion; also interacts with Ubc7p Gene:PRM8(YGL053W)|FD-Score:3.13|P-value:8.76E-4||SGD DESC:Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family Gene:RAM1(YDL090C)|FD-Score:4.78|P-value:8.87E-7||SGD DESC:Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit Gene:TRM3(YDL112W)|FD-Score:3.96|P-value:3.70E-5||SGD DESC:2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs Gene:TVP18(YMR071C)|FD-Score:3.39|P-value:3.44E-4||SGD DESC:Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments Gene:YDR061W(YDR061W_p)|FD-Score:-3.12|P-value:8.92E-4||SGD DESC:Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance Gene:YDR161W(YDR161W_p)|FD-Score:4.91|P-value:4.63E-7||SGD DESC:Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD) Gene:YFR018C(YFR018C_p)|FD-Score:-3.12|P-value:9.10E-4||SGD DESC:Putative protein of unknown function Gene:YFR020W(YFR020W_p)|FD-Score:-4.13|P-value:1.80E-5||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YJR124C(YJR124C_p)|FD-Score:3.31|P-value:4.70E-4||SGD DESC:Putative protein of unknown function; expression induced under calcium shortage Gene:YLR202C(YLR202C_d)|FD-Score:6.78|P-value:5.82E-12||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron Gene:YLR285C-A(YLR285C-A_p)|FD-Score:-3.26|P-value:5.57E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YMR099C(YMR099C)|FD-Score:3.55|P-value:1.95E-4||SGD DESC:Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS Gene:YOR248W(YOR248W_d)|FD-Score:3.57|P-value:1.81E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPR039W(YPR039W_d)|FD-Score:4.1|P-value:2.02E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W Gene:YPR114W(YPR114W_p)|FD-Score:4.73|P-value:1.13E-6||SGD DESC:Putative protein of unknown function Gene:YPT6(YLR262C)|FD-Score:4.02|P-value:2.94E-5||SGD DESC:Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 Gene:YSC83(YHR017W)|FD-Score:3.53|P-value:2.10E-4||SGD DESC:Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YNL313C3.836.31E-50.20EMW1Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress
YGL172W3.817.06E-50.20NUP49FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p)
YMR185W_p3.621.45E-40.20RTP1_pProtein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene
YDL143W3.542.03E-40.20CCT4Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YGL001C3.512.27E-40.20ERG26C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
YOR206W3.472.61E-40.20NOC2Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors
YNL114C_d3.304.87E-40.20YNL114C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit
YNL232W3.226.52E-40.20CSL4Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)
YNL207W3.148.33E-40.20RIO2Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p
YGR185C2.950.001600.03TYS1Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress
YGR115C_d2.920.001740.03YGR115C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C
YHR196W2.900.001890.01UTP9Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YDL221W_d2.890.001930.02YDL221W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13
YOR319W2.870.002040.04HSH49U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)
YKL145W2.840.002290.03RPT1One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YLR202C_d6.785.82E-12YLR202C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
YDR161W_p4.914.63E-7YDR161W_pPutative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD)
YDL090C4.788.87E-7RAM1Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
YPR114W_p4.731.13E-6YPR114W_pPutative protein of unknown function
YHL013C4.552.65E-6OTU2Protein of unknown function; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress
YPR039W_d4.102.02E-5YPR039W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W
YGR257C4.042.62E-5MTM1Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor
YML078W4.042.70E-5CPR3Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria
YLR262C4.022.94E-5YPT6Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
YBR009C3.983.41E-5HHF1Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YDL112W3.963.70E-5TRM32'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs
YAR050W3.944.10E-5FLO1Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YNL322C3.739.73E-5KRE1Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
YLR303W3.691.13E-4MET17Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis
YOR248W_d3.571.81E-4YOR248W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

GO enrichment analysis for SGTC_485
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.0773.06E-9SGTC_6164092-0450 108.0 μMChemDiv (Drug-like library)7871650.104478
0.0706.73E-8SGTC_12730849-0096 14.1 μMChemDiv (Drug-like library)52860250.0895522RPP1 & pyrimidine depletion
0.0707.25E-8SGTC_13983558-0053 112.0 μMChemDiv (Drug-like library)45323690.139535
0.0673.05E-7SGTC_14384092-1045 4.0 μMChemDiv (Drug-like library)1351342NA
0.0621.81E-6SGTC_9443370-0224 231.0 μMChemDiv (Drug-like library)45805140.15873
0.0621.88E-6SGTC_31849108758 49.5 μMChembridge (Drug-like library)9028850.196721
0.0622.06E-6SGTC_7323970-1727 52.7 μMChemDiv (Drug-like library)12756990.0574713
0.0613.08E-6SGTC_2517totarol 10.0 μMMicrosource (Natural product library)4601780.0540541
0.0603.61E-6SGTC_15823',3',6'-trihydroxyflavone 74.0 μMTimTec (Pure natural product library)6888030.125
0.0588.11E-6SGTC_4732-arachidonoylglycerol 10.0 μMICCB bioactive library52822800.057971
0.0587.71E-6SGTC_20064011487 200.0 μMChembridge (Fragment library)455952940.0677966endomembrane recycling
0.0588.79E-6SGTC_20094012297 12.1 μMChembridge (Fragment library)455953070.0909091cell wall signaling
0.0571.01E-5SGTC_13671812-0510 76.9 μMChemDiv (Drug-like library)11425820.16
0.0571.15E-5SGTC_860417-1630 471.9 μMChemDiv (Drug-like library)36348670.037037ubiquinone biosynthesis & proteasome
0.0561.43E-5SGTC_487nimodipine 119.0 μMMiscellaneous44970.108434

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_1349flufenamic acid69 μM0.6444443371ChemDiv (Drug-like library)281.229913.95226
SGTC_350k064-002019.8 μM0.4117652790705ChemDiv (Drug-like library)338.325835.84515heme requiring
SGTC_1463k081-003234.1 μM0.392857977755ChemDiv (Drug-like library)345.114633.15415
SGTC_166k072-0058166.42 μM0.3859655846229ChemDiv (Drug-like library)308.255254.0227DNA intercalators
SGTC_2902578700660.46 μM0.362069591003Chembridge (Drug-like library)309.240013.32516Golgi
SGTC_2476580691610.51 μM0.3538462870194Miscellaneous395.352393.63918
SGTC_2934049-027338.5 μM0.3518521380311ChemDiv (Drug-like library)380.180274.00816
SGTC_8041595-005420.9 μM0.345455761523ChemDiv (Drug-like library)343.363954.71816sphingolipid biosynthesis & PDR1
SGTC_9691313-0238134 μM0.3442625212874ChemDiv (Drug-like library)352.264753.37117mitochondrial processes
SGTC_9073448-698675.5 μM0.323077590582ChemDiv (Drug-like library)352.307813.35126