| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YKL118W_d | 7.15 | 4.42E-13 | YKL118W_d | Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2 |
| YKL026C | 6.01 | 9.47E-10 | GPX1 | Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress |
| YOR147W | 5.78 | 3.67E-9 | MDM32 | Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34 |
| YFR024C-A | 5.36 | 4.15E-8 | LSB3 | Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication |
| YMR015C | 4.90 | 4.87E-7 | ERG5 | C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs |
| YER093C-A | 4.89 | 4.95E-7 | AIM11 | Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication |
| YPR149W | 4.87 | 5.68E-7 | NCE102 | Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs) |
| YNL041C | 4.73 | 1.13E-6 | COG6 | Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments |
| YOR188W | 4.68 | 1.44E-6 | MSB1 | Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress |
| YHR108W | 4.68 | 1.46E-6 | GGA2 | Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin |
| YPL156C | 4.64 | 1.77E-6 | PRM4 | Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift |
| YNL193W_p | 4.47 | 3.98E-6 | YNL193W_p | Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis |
| YKR056W | 4.44 | 4.52E-6 | TRM2 | tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair |
| YOR386W | 4.34 | 6.99E-6 | PHR1 | DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p |
| YGL184C | 4.28 | 9.34E-6 | STR3 | Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p |
