Deletion Strain | FD score | P-value | Gene | Gene Description |
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YBR093C | 7.64 | 1.11E-14 | PHO5 | Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2 |
YOR136W | 7.59 | 1.54E-14 | IDH2 | Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated |
YPL014W_p | 5.24 | 8.12E-8 | YPL014W_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus |
YBR015C | 5.08 | 1.91E-7 | MNN2 | Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment |
YGR276C | 5.05 | 2.20E-7 | RNH70 | 3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts |
YLR324W | 4.79 | 8.23E-7 | PEX30 | Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p |
YML072C | 4.72 | 1.17E-6 | TCB3 | Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact |
YAL044C | 4.57 | 2.42E-6 | GCV3 | H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF |
YLR390W | 4.47 | 3.96E-6 | ECM19 | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
YER162C | 4.36 | 6.57E-6 | RAD4 | Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins |
YPL186C | 4.35 | 6.81E-6 | UIP4 | Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope |
YOL129W | 4.22 | 1.21E-5 | VPS68 | Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria |
YOR114W_p | 4.21 | 1.26E-5 | YOR114W_p | Putative protein of unknown function; null mutant is viable |
YGL244W | 4.11 | 1.99E-5 | RTF1 | Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay |
YPL002C | 3.94 | 4.01E-5 | SNF8 | Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression |