ag-490

(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_510
Screen concentration 170.0 μM
Source ICCB bioactive library
PubChem CID 5328779
SMILES C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N
Standardized SMILES Oc1ccc(C=C(C#N)C(=O)NCc2ccccc2)cc1O
Molecular weight 294.3047
ALogP 2.44
H-bond donor count 3
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 2.81
% growth inhibition (Hom. pool) -1.45


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 5328779
Download HIP data (tab-delimited text)  (excel)
Gene:CDC31(YOR257W)|FD-Score:3.87|P-value:5.51E-5|Clearance:0.32||SGD DESC:Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation Gene:PRP3(YDR473C)|FD-Score:3.49|P-value:2.42E-4|Clearance:0.32||SGD DESC:Splicing factor, component of the U4/U6-U5 snRNP complex Gene:RET3(YPL010W)|FD-Score:-3.58|P-value:1.69E-4|Clearance:0||SGD DESC:Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER Gene:SHQ1(YIL104C)|FD-Score:-3.33|P-value:4.33E-4|Clearance:0||SGD DESC:Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones Gene:TEL2(YGR099W)|FD-Score:3.78|P-value:7.71E-5|Clearance:0.32||SGD DESC:Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1 Gene:TIM23(YNR017W)|FD-Score:3.3|P-value:4.85E-4|Clearance:0.32||SGD DESC:Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel Gene:CDC31(YOR257W)|FD-Score:3.87|P-value:5.51E-5|Clearance:0.32||SGD DESC:Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation Gene:PRP3(YDR473C)|FD-Score:3.49|P-value:2.42E-4|Clearance:0.32||SGD DESC:Splicing factor, component of the U4/U6-U5 snRNP complex Gene:RET3(YPL010W)|FD-Score:-3.58|P-value:1.69E-4|Clearance:0||SGD DESC:Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER Gene:SHQ1(YIL104C)|FD-Score:-3.33|P-value:4.33E-4|Clearance:0||SGD DESC:Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones Gene:TEL2(YGR099W)|FD-Score:3.78|P-value:7.71E-5|Clearance:0.32||SGD DESC:Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1 Gene:TIM23(YNR017W)|FD-Score:3.3|P-value:4.85E-4|Clearance:0.32||SGD DESC:Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 5328779
Download HOP data (tab-delimited text)  (excel)
Gene:AFT1(YGL071W)|FD-Score:3.7|P-value:1.09E-4||SGD DESC:Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:DOS2(YDR068W)|FD-Score:3.34|P-value:4.14E-4||SGD DESC:Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:GAL83(YER027C)|FD-Score:-4.23|P-value:1.17E-5||SGD DESC:One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain Gene:NMA111(YNL123W)|FD-Score:3.23|P-value:6.26E-4||SGD DESC:Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases Gene:PDR12(YPL058C)|FD-Score:-3.09|P-value:9.96E-4||SGD DESC:Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity Gene:PIG1(YLR273C)|FD-Score:3.34|P-value:4.25E-4||SGD DESC:Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase Gene:RPS23A(YGR118W)|FD-Score:4.12|P-value:1.88E-5||SGD DESC:Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal Gene:SEC72(YLR292C)|FD-Score:3.32|P-value:4.53E-4||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SHM2(YLR058C)|FD-Score:4.06|P-value:2.41E-5||SGD DESC:Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis Gene:SLT2(YHR030C)|FD-Score:3.96|P-value:3.71E-5||SGD DESC:Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway Gene:SSP120(YLR250W)|FD-Score:3.19|P-value:7.21E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:SVF1(YDR346C)|FD-Score:3.36|P-value:3.84E-4||SGD DESC:Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance Gene:YBR242W(YBR242W_p)|FD-Score:3.27|P-value:5.39E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene Gene:YDR222W(YDR222W_p)|FD-Score:3.31|P-value:4.64E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:YEL010W(YEL010W_d)|FD-Score:3.37|P-value:3.78E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGR121W-A(YGR121W-A_p)|FD-Score:3.61|P-value:1.51E-4||SGD DESC:Putative protein of unknown function Gene:YIH1(YCR059C)|FD-Score:3.13|P-value:8.78E-4||SGD DESC:Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT Gene:YMR074C(YMR074C)|FD-Score:-3.66|P-value:1.26E-4||SGD DESC:Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress Gene:YPT6(YLR262C)|FD-Score:3.57|P-value:1.80E-4||SGD DESC:Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 Gene:AFT1(YGL071W)|FD-Score:3.7|P-value:1.09E-4||SGD DESC:Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:DOS2(YDR068W)|FD-Score:3.34|P-value:4.14E-4||SGD DESC:Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:GAL83(YER027C)|FD-Score:-4.23|P-value:1.17E-5||SGD DESC:One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain Gene:NMA111(YNL123W)|FD-Score:3.23|P-value:6.26E-4||SGD DESC:Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases Gene:PDR12(YPL058C)|FD-Score:-3.09|P-value:9.96E-4||SGD DESC:Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity Gene:PIG1(YLR273C)|FD-Score:3.34|P-value:4.25E-4||SGD DESC:Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase Gene:RPS23A(YGR118W)|FD-Score:4.12|P-value:1.88E-5||SGD DESC:Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal Gene:SEC72(YLR292C)|FD-Score:3.32|P-value:4.53E-4||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SHM2(YLR058C)|FD-Score:4.06|P-value:2.41E-5||SGD DESC:Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis Gene:SLT2(YHR030C)|FD-Score:3.96|P-value:3.71E-5||SGD DESC:Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway Gene:SSP120(YLR250W)|FD-Score:3.19|P-value:7.21E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:SVF1(YDR346C)|FD-Score:3.36|P-value:3.84E-4||SGD DESC:Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance Gene:YBR242W(YBR242W_p)|FD-Score:3.27|P-value:5.39E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene Gene:YDR222W(YDR222W_p)|FD-Score:3.31|P-value:4.64E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:YEL010W(YEL010W_d)|FD-Score:3.37|P-value:3.78E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGR121W-A(YGR121W-A_p)|FD-Score:3.61|P-value:1.51E-4||SGD DESC:Putative protein of unknown function Gene:YIH1(YCR059C)|FD-Score:3.13|P-value:8.78E-4||SGD DESC:Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT Gene:YMR074C(YMR074C)|FD-Score:-3.66|P-value:1.26E-4||SGD DESC:Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress Gene:YPT6(YLR262C)|FD-Score:3.57|P-value:1.80E-4||SGD DESC:Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YOR257W3.875.51E-50.32CDC31Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation
YGR099W3.787.71E-50.32TEL2Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1
YDR473C3.492.42E-40.32PRP3Splicing factor, component of the U4/U6-U5 snRNP complex
YNR017W3.304.85E-40.32TIM23Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel
YDL092W2.980.001430.25SRP14Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14
YPR105C2.740.003100.06COG4Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YNL163C2.670.003750.08RIA1Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes
YBR089W_d2.600.004730.02YBR089W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30
YGL073W2.570.005030.10HSF1Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated
YNL124W2.480.006660.05NAF1RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
YDL195W2.430.007650.00SEC31Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance
YCR012W2.420.007730.01PGK13-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
YDR280W2.410.007970.04RRP45Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
YJL173C2.370.008940.04RFA3Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
YDR267C2.330.009850.02CIA1Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YGR118W4.121.88E-5RPS23ARibosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
YLR058C4.062.41E-5SHM2Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis
YHR030C3.963.71E-5SLT2Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway
YGL071W3.701.09E-4AFT1Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
YGR121W-A_p3.611.51E-4YGR121W-A_pPutative protein of unknown function
YLR262C3.571.80E-4YPT6Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
YEL010W_d3.373.78E-4YEL010W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR346C3.363.84E-4SVF1Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance
YDR068W3.344.14E-4DOS2Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YLR273C3.344.25E-4PIG1Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase
YLR292C3.324.53E-4SEC72Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YDR222W_p3.314.64E-4YDR222W_pProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YBR242W_p3.275.39E-4YBR242W_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene
YNL123W3.236.26E-4NMA111Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
YLR250W3.197.21E-4SSP120Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern

GO enrichment analysis for SGTC_510
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.2419.06E-79SGTC_508roscovitine 141.0 μMICCB bioactive library1603550.166667
0.1223.73E-21SGTC_29249010168 62.8 μMChembridge (Drug-like library)29939290.15942cell wall signaling
0.1157.71E-19SGTC_1614st002383 48.6 μMTimTec (Natural product derivative library)19472350.192308cell wall signaling
0.1132.70E-18SGTC_22687933382 153.8 μMChembridge (Fragment library)9350250.0833333
0.1111.15E-17SGTC_3690957-0393 4.5 μMChemDiv (Drug-like library)69979920.137931cell wall signaling
0.1081.13E-16SGTC_509pifithrin 175.0 μMICCB bioactive library48170.0958904mitochondrial processes
0.1056.48E-16SGTC_1081sertraline 6.0 μMNIH Clinical Collection630090.10294160S ribosome export
0.1018.16E-15SGTC_9052-aminofluorene 215.0 μMChemDiv (Drug-like library)15390.103448cell wall signaling
0.0984.48E-14SGTC_22107115885 190.4 μMChembridge (Fragment library)29270390.0645161cell wall signaling
0.0961.22E-13SGTC_6631486-0733 13.9 μMChemDiv (Drug-like library)7224450.125cell wall signaling
0.0943.82E-13SGTC_2776terbinafine 19.9 μMNIH Clinical Collection52824810.111111cell wall signaling
0.0871.70E-11SGTC_1280906-2981 13.4 μMChemDiv (Drug-like library)67402260.202899
0.0863.72E-11SGTC_21495554786 194.8 μMChembridge (Fragment library)7450630.0869565cell wall signaling
0.0856.16E-11SGTC_500h-89 112.0 μMICCB bioactive library4492410.123457cell wall signaling
0.0815.79E-10SGTC_6420335-0876 158.0 μMChemDiv (Drug-like library)68123500.150685ubiquinone biosynthesis & proteasome

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_442cape100 μM0.4107145281787ICCB bioactive library284.306543.57324
SGTC_8710574-0004149 μM0.3965529551173ChemDiv (Drug-like library)306.315363.83514
SGTC_1652st01193278 μM0.3225811551076TimTec (Natural product derivative library)245.230742.10905RSC complex & mRNA processing
SGTC_7521896-0090130 μM0.322034772567ChemDiv (Drug-like library)294.147182.04913TSC3-RPN4
SGTC_320928-014234.1 μM0.2903232244242ChemDiv (Drug-like library)329.393444.13925TSC3-RPN4
SGTC_2876905990325.97 μM0.2903236916095Chembridge (Drug-like library)283.364843.91312
SGTC_3531988-117558.3 μM0.2881362788357ChemDiv (Drug-like library)269.29522.39413unfolded protein response
SGTC_1651st01192886.1 μM0.288136720198TimTec (Natural product derivative library)232.258421.77414RSC complex & mRNA processing
SGTC_503tyrphostin 8294 μM0.28571492970ICCB bioactive library170.167441.77313TSC3-RPN4
SGTC_462ag-879158 μM0.2711866809654ICCB bioactive library316.460963.88224