Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YJL167W | 4.06 | 2.42E-5 | 0.33 | ERG20 | Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis |
YGR099W | 3.99 | 3.28E-5 | 0.33 | TEL2 | Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1 |
YGR264C | 3.66 | 1.26E-4 | 0.04 | MES1 | Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs |
YGL099W | 3.62 | 1.47E-4 | 0.04 | LSG1 | Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm |
YPR082C | 3.58 | 1.70E-4 | 0.07 | DIB1 | 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein |
YBR011C | 3.51 | 2.22E-4 | 0.27 | IPP1 | Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase |
YNL182C | 3.24 | 6.00E-4 | 0.13 | IPI3 | Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene |
YNL039W | 3.11 | 9.44E-4 | 0.07 | BDP1 | Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs |
YDL145C | 3.03 | 0.00121 | 0.25 | COP1 | Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway |
YJR045C | 2.79 | 0.00267 | 0.11 | SSC1 | Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog, ECM10, that arose from the whole genome duplication |
YDL029W | 2.68 | 0.00373 | 0.00 | ARP2 | Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity |
YGL238W | 2.67 | 0.00376 | 0.02 | CSE1 | Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation |
YBR202W | 2.65 | 0.00403 | 0.04 | MCM7 | Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex |
YDL028C | 2.60 | 0.00459 | 0.08 | MPS1 | Dual-specificity kinase; required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p |
YLR140W_d | 2.53 | 0.00575 | 0.05 | YLR140W_d | Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I |