4076-0302

3-[(Z)-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-ylhydrazinylidene)methyl]phenol

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_529
Screen concentration 30.3 μM
Source ChemDiv (Drug-like library)
PubChem CID 5816522
SMILES C1CCC2=C(C1)C3=C(N=CN=C3S2)NN=CC4=CC(=CC=C4)O
Standardized SMILES Oc1cccc(C=NNc2ncnc3sc4CCCCc4c23)c1
Molecular weight 324.4001
ALogP 4.41
H-bond donor count 2
H-bond acceptor count 6
Response signature mitochondrial processes

Pool Growth Kinetics
% growth inhibition (Het. pool) 19.7
% growth inhibition (Hom. pool) 13.33


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 5816522
Download HIP data (tab-delimited text)  (excel)
Gene:KIN28(YDL108W)|FD-Score:7.59|P-value:1.56E-14|Clearance:1.78||SGD DESC:Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters Gene:NAF1(YNL124W)|FD-Score:3.43|P-value:3.07E-4|Clearance:0.02||SGD DESC:RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p Gene:NMD3(YHR170W)|FD-Score:5.06|P-value:2.10E-7|Clearance:0.54||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:NOP14(YDL148C)|FD-Score:4.1|P-value:2.04E-5|Clearance:0.22||SGD DESC:Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA Gene:RIX1(YHR197W)|FD-Score:3.71|P-value:1.02E-4|Clearance:0.2||SGD DESC:Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; RIX1 is an essential gene Gene:RPL30(YGL030W)|FD-Score:3.88|P-value:5.19E-5|Clearance:0.17||SGD DESC:Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog Gene:RPO26(YPR187W)|FD-Score:4.43|P-value:4.71E-6|Clearance:0.33||SGD DESC:RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit Gene:RSC8(YFR037C)|FD-Score:4.52|P-value:3.10E-6|Clearance:0.09||SGD DESC:Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters Gene:RSC9(YML127W)|FD-Score:3.4|P-value:3.34E-4|Clearance:0.16||SGD DESC:Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway Gene:SSY1(YDR160W)|FD-Score:3.51|P-value:2.22E-4|Clearance:0.09||SGD DESC:Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes Gene:TAM41(YGR046W)|FD-Score:-3.29|P-value:5.06E-4|Clearance:0||SGD DESC:Mitochondrial protein required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition Gene:TIF5(YPR041W)|FD-Score:5.81|P-value:3.14E-9|Clearance:0.75||SGD DESC:Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2 Gene:YDL196W(YDL196W_d)|FD-Score:3.25|P-value:5.86E-4|Clearance:0.26||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 Gene:KIN28(YDL108W)|FD-Score:7.59|P-value:1.56E-14|Clearance:1.78||SGD DESC:Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters Gene:NAF1(YNL124W)|FD-Score:3.43|P-value:3.07E-4|Clearance:0.02||SGD DESC:RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p Gene:NMD3(YHR170W)|FD-Score:5.06|P-value:2.10E-7|Clearance:0.54||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:NOP14(YDL148C)|FD-Score:4.1|P-value:2.04E-5|Clearance:0.22||SGD DESC:Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA Gene:RIX1(YHR197W)|FD-Score:3.71|P-value:1.02E-4|Clearance:0.2||SGD DESC:Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; RIX1 is an essential gene Gene:RPL30(YGL030W)|FD-Score:3.88|P-value:5.19E-5|Clearance:0.17||SGD DESC:Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog Gene:RPO26(YPR187W)|FD-Score:4.43|P-value:4.71E-6|Clearance:0.33||SGD DESC:RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit Gene:RSC8(YFR037C)|FD-Score:4.52|P-value:3.10E-6|Clearance:0.09||SGD DESC:Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters Gene:RSC9(YML127W)|FD-Score:3.4|P-value:3.34E-4|Clearance:0.16||SGD DESC:Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway Gene:SSY1(YDR160W)|FD-Score:3.51|P-value:2.22E-4|Clearance:0.09||SGD DESC:Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes Gene:TAM41(YGR046W)|FD-Score:-3.29|P-value:5.06E-4|Clearance:0||SGD DESC:Mitochondrial protein required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition Gene:TIF5(YPR041W)|FD-Score:5.81|P-value:3.14E-9|Clearance:0.75||SGD DESC:Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2 Gene:YDL196W(YDL196W_d)|FD-Score:3.25|P-value:5.86E-4|Clearance:0.26||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 5816522
Download HOP data (tab-delimited text)  (excel)
Gene:BXI1(YNL305C)|FD-Score:-4.21|P-value:1.29E-5||SGD DESC:Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p Gene:COX18(YGR062C)|FD-Score:6.34|P-value:1.13E-10||SGD DESC:Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC Gene:CWC21(YDR482C)|FD-Score:-3.26|P-value:5.60E-4||SGD DESC:Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p Gene:DAL1(YIR027C)|FD-Score:-3.31|P-value:4.69E-4||SGD DESC:Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression Gene:DNM1(YLL001W)|FD-Score:4.17|P-value:1.53E-5||SGD DESC:Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance Gene:FCY1(YPR062W)|FD-Score:4.47|P-value:3.82E-6||SGD DESC:Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) Gene:GEM1(YAL048C)|FD-Score:3.24|P-value:5.87E-4||SGD DESC:Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases Gene:GIM4(YEL003W)|FD-Score:4.01|P-value:3.08E-5||SGD DESC:Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it Gene:GMC1(YDR506C)|FD-Score:6.38|P-value:8.98E-11||SGD DESC:Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein Gene:GTB1(YDR221W)|FD-Score:-3.35|P-value:4.00E-4||SGD DESC:Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress Gene:HMF1(YER057C)|FD-Score:-4.38|P-value:5.82E-6||SGD DESC:Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro Gene:HOP1(YIL072W)|FD-Score:3.35|P-value:4.00E-4||SGD DESC:Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments Gene:HSP30(YCR021C)|FD-Score:3.3|P-value:4.82E-4||SGD DESC:Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase Gene:IES5(YER092W)|FD-Score:3.09|P-value:9.90E-4||SGD DESC:Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions Gene:IME4(YGL192W)|FD-Score:3.7|P-value:1.07E-4||SGD DESC:Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids Gene:INP54(YOL065C)|FD-Score:-3.74|P-value:9.37E-5||SGD DESC:Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins Gene:IOC3(YFR013W)|FD-Score:3.39|P-value:3.51E-4||SGD DESC:Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; IOC3 has a paralog, ESC8, that arose from the whole genome duplication Gene:MAC1(YMR021C)|FD-Score:-3.14|P-value:8.44E-4||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MLH3(YPL164C)|FD-Score:3.37|P-value:3.79E-4||SGD DESC:Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability Gene:NVJ1(YHR195W)|FD-Score:5.03|P-value:2.45E-7||SGD DESC:Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) Gene:PAM17(YKR065C)|FD-Score:5.82|P-value:2.92E-9||SGD DESC:Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress Gene:PCK1(YKR097W)|FD-Score:4.84|P-value:6.54E-7||SGD DESC:Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol Gene:PEX28(YHR150W)|FD-Score:3.15|P-value:8.19E-4||SGD DESC:Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p Gene:PUT4(YOR348C)|FD-Score:4.34|P-value:6.97E-6||SGD DESC:Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells Gene:QDR3(YBR043C)|FD-Score:3.77|P-value:8.02E-5||SGD DESC:Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin Gene:RCE1(YMR274C)|FD-Score:3.32|P-value:4.43E-4||SGD DESC:Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone Gene:REI1(YBR267W)|FD-Score:3.23|P-value:6.20E-4||SGD DESC:Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network Gene:RGC1(YPR115W)|FD-Score:-3.59|P-value:1.63E-4||SGD DESC:Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication Gene:RIM15(YFL033C)|FD-Score:3.44|P-value:2.96E-4||SGD DESC:Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase Gene:RPL42B(YHR141C)|FD-Score:-4.34|P-value:7.22E-6||SGD DESC:Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42B has a paralog, RPL42A, that arose from the whole genome duplication Gene:RPL6B(YLR448W)|FD-Score:4.32|P-value:7.72E-6||SGD DESC:Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication Gene:SIP4(YJL089W)|FD-Score:4.52|P-value:3.15E-6||SGD DESC:C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus Gene:SLZ1(YNL196C_p)|FD-Score:-3.97|P-value:3.53E-5||SGD DESC:Sporulation-specific protein with a leucine zipper motif Gene:TDA5(YLR426W_p)|FD-Score:4.24|P-value:1.11E-5||SGD DESC:Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele Gene:THI6(YPL214C)|FD-Score:4.25|P-value:1.09E-5||SGD DESC:Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern Gene:TIR1(YER011W)|FD-Score:-3.47|P-value:2.63E-4||SGD DESC:Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking Gene:UBA4(YHR111W)|FD-Score:-3.32|P-value:4.56E-4||SGD DESC:Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p Gene:URA7(YBL039C)|FD-Score:3.36|P-value:3.84E-4||SGD DESC:Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication Gene:VMA7(YGR020C)|FD-Score:5.24|P-value:7.82E-8||SGD DESC:Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane Gene:YAR047C(YAR047C_d)|FD-Score:3.34|P-value:4.21E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YBL039W-B(YBL039W-B_p)|FD-Score:-5.85|P-value:2.49E-9||SGD DESC:Putative protein of unknown function Gene:YBR072C-A(YBR072C-A_p)|FD-Score:3.09|P-value:9.86E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YDL062W(YDL062W_d)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential Gene:YDL218W(YDL218W_p)|FD-Score:4.39|P-value:5.60E-6||SGD DESC:Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin Gene:YDR541C(YDR541C_p)|FD-Score:3.91|P-value:4.66E-5||SGD DESC:Putative dihydrokaempferol 4-reductase Gene:YFL015C(YFL015C_d)|FD-Score:3.56|P-value:1.86E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene Gene:YFL041W-A(YFL041W-A_p)|FD-Score:3.09|P-value:9.90E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YFR018C(YFR018C_p)|FD-Score:3.16|P-value:7.76E-4||SGD DESC:Putative protein of unknown function Gene:YGL109W(YGL109W_d)|FD-Score:-4.24|P-value:1.11E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C Gene:YGR122W(YGR122W)|FD-Score:3.86|P-value:5.62E-5||SGD DESC:Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress Gene:YHR022C(YHR022C_p)|FD-Score:4.14|P-value:1.71E-5||SGD DESC:Putative protein of unknown function; YHR022C is not an essential gene Gene:YIR020W-A(YIR020W-A_d)|FD-Score:4.18|P-value:1.46E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Gene:YJR149W(YJR149W_p)|FD-Score:3.17|P-value:7.75E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YLR184W(YLR184W_d)|FD-Score:3.11|P-value:9.26E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR416C(YLR416C_d)|FD-Score:3.11|P-value:9.27E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR253C(YMR253C_p)|FD-Score:3.76|P-value:8.55E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene Gene:YMR265C(YMR265C_p)|FD-Score:5.19|P-value:1.05E-7||SGD DESC:Putative protein of unknown function Gene:YMR320W(YMR320W_d)|FD-Score:3.29|P-value:5.08E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YNL122C(YNL122C_p)|FD-Score:3.64|P-value:1.34E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene Gene:YNL228W(YNL228W_d)|FD-Score:5.07|P-value:1.97E-7||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1 Gene:YOR082C(YOR082C_d)|FD-Score:3.46|P-value:2.66E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W Gene:YPR098C(YPR098C)|FD-Score:-3.55|P-value:1.96E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:BXI1(YNL305C)|FD-Score:-4.21|P-value:1.29E-5||SGD DESC:Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p Gene:COX18(YGR062C)|FD-Score:6.34|P-value:1.13E-10||SGD DESC:Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC Gene:CWC21(YDR482C)|FD-Score:-3.26|P-value:5.60E-4||SGD DESC:Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p Gene:DAL1(YIR027C)|FD-Score:-3.31|P-value:4.69E-4||SGD DESC:Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression Gene:DNM1(YLL001W)|FD-Score:4.17|P-value:1.53E-5||SGD DESC:Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance Gene:FCY1(YPR062W)|FD-Score:4.47|P-value:3.82E-6||SGD DESC:Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) Gene:GEM1(YAL048C)|FD-Score:3.24|P-value:5.87E-4||SGD DESC:Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases Gene:GIM4(YEL003W)|FD-Score:4.01|P-value:3.08E-5||SGD DESC:Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it Gene:GMC1(YDR506C)|FD-Score:6.38|P-value:8.98E-11||SGD DESC:Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein Gene:GTB1(YDR221W)|FD-Score:-3.35|P-value:4.00E-4||SGD DESC:Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress Gene:HMF1(YER057C)|FD-Score:-4.38|P-value:5.82E-6||SGD DESC:Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro Gene:HOP1(YIL072W)|FD-Score:3.35|P-value:4.00E-4||SGD DESC:Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments Gene:HSP30(YCR021C)|FD-Score:3.3|P-value:4.82E-4||SGD DESC:Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase Gene:IES5(YER092W)|FD-Score:3.09|P-value:9.90E-4||SGD DESC:Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions Gene:IME4(YGL192W)|FD-Score:3.7|P-value:1.07E-4||SGD DESC:Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids Gene:INP54(YOL065C)|FD-Score:-3.74|P-value:9.37E-5||SGD DESC:Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins Gene:IOC3(YFR013W)|FD-Score:3.39|P-value:3.51E-4||SGD DESC:Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; IOC3 has a paralog, ESC8, that arose from the whole genome duplication Gene:MAC1(YMR021C)|FD-Score:-3.14|P-value:8.44E-4||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MLH3(YPL164C)|FD-Score:3.37|P-value:3.79E-4||SGD DESC:Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability Gene:NVJ1(YHR195W)|FD-Score:5.03|P-value:2.45E-7||SGD DESC:Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) Gene:PAM17(YKR065C)|FD-Score:5.82|P-value:2.92E-9||SGD DESC:Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress Gene:PCK1(YKR097W)|FD-Score:4.84|P-value:6.54E-7||SGD DESC:Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol Gene:PEX28(YHR150W)|FD-Score:3.15|P-value:8.19E-4||SGD DESC:Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p Gene:PUT4(YOR348C)|FD-Score:4.34|P-value:6.97E-6||SGD DESC:Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells Gene:QDR3(YBR043C)|FD-Score:3.77|P-value:8.02E-5||SGD DESC:Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin Gene:RCE1(YMR274C)|FD-Score:3.32|P-value:4.43E-4||SGD DESC:Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone Gene:REI1(YBR267W)|FD-Score:3.23|P-value:6.20E-4||SGD DESC:Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network Gene:RGC1(YPR115W)|FD-Score:-3.59|P-value:1.63E-4||SGD DESC:Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication Gene:RIM15(YFL033C)|FD-Score:3.44|P-value:2.96E-4||SGD DESC:Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase Gene:RPL42B(YHR141C)|FD-Score:-4.34|P-value:7.22E-6||SGD DESC:Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42B has a paralog, RPL42A, that arose from the whole genome duplication Gene:RPL6B(YLR448W)|FD-Score:4.32|P-value:7.72E-6||SGD DESC:Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication Gene:SIP4(YJL089W)|FD-Score:4.52|P-value:3.15E-6||SGD DESC:C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus Gene:SLZ1(YNL196C_p)|FD-Score:-3.97|P-value:3.53E-5||SGD DESC:Sporulation-specific protein with a leucine zipper motif Gene:TDA5(YLR426W_p)|FD-Score:4.24|P-value:1.11E-5||SGD DESC:Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele Gene:THI6(YPL214C)|FD-Score:4.25|P-value:1.09E-5||SGD DESC:Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern Gene:TIR1(YER011W)|FD-Score:-3.47|P-value:2.63E-4||SGD DESC:Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking Gene:UBA4(YHR111W)|FD-Score:-3.32|P-value:4.56E-4||SGD DESC:Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p Gene:URA7(YBL039C)|FD-Score:3.36|P-value:3.84E-4||SGD DESC:Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication Gene:VMA7(YGR020C)|FD-Score:5.24|P-value:7.82E-8||SGD DESC:Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane Gene:YAR047C(YAR047C_d)|FD-Score:3.34|P-value:4.21E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YBL039W-B(YBL039W-B_p)|FD-Score:-5.85|P-value:2.49E-9||SGD DESC:Putative protein of unknown function Gene:YBR072C-A(YBR072C-A_p)|FD-Score:3.09|P-value:9.86E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YDL062W(YDL062W_d)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential Gene:YDL218W(YDL218W_p)|FD-Score:4.39|P-value:5.60E-6||SGD DESC:Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin Gene:YDR541C(YDR541C_p)|FD-Score:3.91|P-value:4.66E-5||SGD DESC:Putative dihydrokaempferol 4-reductase Gene:YFL015C(YFL015C_d)|FD-Score:3.56|P-value:1.86E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene Gene:YFL041W-A(YFL041W-A_p)|FD-Score:3.09|P-value:9.90E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YFR018C(YFR018C_p)|FD-Score:3.16|P-value:7.76E-4||SGD DESC:Putative protein of unknown function Gene:YGL109W(YGL109W_d)|FD-Score:-4.24|P-value:1.11E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C Gene:YGR122W(YGR122W)|FD-Score:3.86|P-value:5.62E-5||SGD DESC:Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress Gene:YHR022C(YHR022C_p)|FD-Score:4.14|P-value:1.71E-5||SGD DESC:Putative protein of unknown function; YHR022C is not an essential gene Gene:YIR020W-A(YIR020W-A_d)|FD-Score:4.18|P-value:1.46E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Gene:YJR149W(YJR149W_p)|FD-Score:3.17|P-value:7.75E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YLR184W(YLR184W_d)|FD-Score:3.11|P-value:9.26E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR416C(YLR416C_d)|FD-Score:3.11|P-value:9.27E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR253C(YMR253C_p)|FD-Score:3.76|P-value:8.55E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene Gene:YMR265C(YMR265C_p)|FD-Score:5.19|P-value:1.05E-7||SGD DESC:Putative protein of unknown function Gene:YMR320W(YMR320W_d)|FD-Score:3.29|P-value:5.08E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YNL122C(YNL122C_p)|FD-Score:3.64|P-value:1.34E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene Gene:YNL228W(YNL228W_d)|FD-Score:5.07|P-value:1.97E-7||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1 Gene:YOR082C(YOR082C_d)|FD-Score:3.46|P-value:2.66E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W Gene:YPR098C(YPR098C)|FD-Score:-3.55|P-value:1.96E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YDL108W7.591.56E-141.78KIN28Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters
YPR041W5.813.14E-90.75TIF5Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2
YHR170W5.062.10E-70.54NMD3Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
YFR037C4.523.10E-60.09RSC8Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
YPR187W4.434.71E-60.33RPO26RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit
YDL148C4.102.04E-50.22NOP14Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
YGL030W3.885.19E-50.17RPL30Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog
YHR197W3.711.02E-40.20RIX1Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; RIX1 is an essential gene
YDR160W3.512.22E-40.09SSY1Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YNL124W3.433.07E-40.02NAF1RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
YML127W3.403.34E-40.16RSC9Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
YDL196W_d3.255.86E-40.27YDL196W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
YAL025C2.980.001440.02MAK16Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus
YDR416W2.960.001550.04SYF1Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
YGL123W2.920.001779.00E-4RPS2Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDR506C6.388.98E-11GMC1Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein
YGR062C6.341.13E-10COX18Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC
YKR065C5.822.92E-9PAM17Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress
YGR020C5.247.82E-8VMA7Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YMR265C_p5.191.05E-7YMR265C_pPutative protein of unknown function
YNL228W_d5.071.97E-7YNL228W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1
YHR195W5.032.45E-7NVJ1Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)
YKR097W4.846.54E-7PCK1Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YJL089W4.523.15E-6SIP4C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YPR062W4.473.82E-6FCY1Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)
YDL218W_p4.395.60E-6YDL218W_pPutative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin
YOR348C4.346.97E-6PUT4Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YLR448W4.327.72E-6RPL6BRibosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication
YPL214C4.251.09E-5THI6Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
YLR426W_p4.241.11E-5TDA5_pPutative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele

GO enrichment analysis for SGTC_529
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0898.73E-12SGTC_509pifithrin 175.0 μMICCB bioactive library48170.0864198mitochondrial processes
0.0831.94E-10SGTC_14924158-0558 28.5 μMChemDiv (Drug-like library)39672680.11494360S ribosome export
0.0791.29E-9SGTC_643k048-0106 28.4 μMChemDiv (Drug-like library)67639200.1125RSC & ERG11
0.0781.97E-9SGTC_534k292-0788 63.4 μMChemDiv (Drug-like library)41463170.0487805mitochondrial processes
0.0722.78E-8SGTC_15004488-1866 171.0 μMChemDiv (Drug-like library)29000030.114583RPP1 & pyrimidine depletion
0.0723.69E-8SGTC_1651st011928 86.1 μMTimTec (Natural product derivative library)7201980.0909091RSC complex & mRNA processing
0.0708.51E-8SGTC_970535-0701 19.1 μMChemDiv (Drug-like library)28320130.083333360S ribosome export
0.0691.07E-7SGTC_322k048-0136 19.3 μMChemDiv (Drug-like library)68232820.105882RSC & ERG11
0.0672.56E-7SGTC_21435623677 140.5 μMChembridge (Fragment library)53753130.05
0.0672.85E-7SGTC_10430916-0009 19.3 μMChemDiv (Drug-like library)31011300.0625
0.0672.94E-7SGTC_3241315-0088 19.6 μMChemDiv (Drug-like library)67874210.135802RSC & ERG11
0.0663.96E-7SGTC_23469031566 143.8 μMChembridge (Fragment library)47710860.0428571Golgi
0.0664.73E-7SGTC_480am 92016 50.0 μMICCB bioactive library21290.0638298
0.0655.86E-7SGTC_32339132340 49.5 μMChembridge (Drug-like library)176829500.0930233
0.0631.12E-6SGTC_1523st012844 44.7 μMTimTec (Pure natural product library)42741030.075471760S ribosome export

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_8010866-002810.1 μM0.5781256849771ChemDiv (Drug-like library)347.436783.65326
SGTC_1883229-0966278.47 μM0.4193555722370ChemDiv (Drug-like library)269.321643.83225
SGTC_243954920307.2 μM0.4193555722370Miscellaneous269.321643.83225
SGTC_3823229-096623.2 μM0.4193555722370ChemDiv (Drug-like library)269.321643.83225
SGTC_5953909-800373.7 μM0.38983699517ChemDiv (Drug-like library)259.369883.65704
SGTC_14083909-797648.8 μM0.32394424152374ChemDiv (Drug-like library)315.456284.12215Golgi
SGTC_14103909-810677.9 μM0.2987011039210ChemDiv (Drug-like library)383.50714.6716
SGTC_13732887-000358.5 μM0.295775776948ChemDiv (Drug-like library)267.348823.32404Golgi
SGTC_14113909-8223150 μM0.291139X1411ChemDiv (Drug-like library)468.656176.19241
SGTC_11961588-0294184 μM0.2898556144269ChemDiv (Drug-like library)355.4125834.57918