Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YHR170W | 4.58 | 2.29E-6 | 0.36 | NMD3 | Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex |
YKR068C | 4.47 | 3.93E-6 | 0.36 | BET3 | Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex |
YLR197W | 4.11 | 2.00E-5 | 0.05 | NOP56 | Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects |
YOR310C | 4.06 | 2.50E-5 | 0.05 | NOP58 | Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA |
YDR510W | 4.00 | 3.14E-5 | 0.12 | SMT3 | Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2 |
YFL009W | 3.89 | 5.11E-5 | 0.05 | CDC4 | F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p |
YHR197W | 3.84 | 6.17E-5 | 0.06 | RIX1 | Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; RIX1 is an essential gene |
YBR193C | 3.78 | 7.90E-5 | 0.07 | MED8 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation |
YNL312W | 3.70 | 1.06E-4 | 0.10 | RFA2 | Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress |
YJL173C | 3.60 | 1.59E-4 | 0.25 | RFA3 | Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress |
YIL004C | 3.35 | 4.00E-4 | 0.05 | BET1 | Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins |
YOL066C | 3.30 | 4.80E-4 | 0.04 | RIB2 | Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs |
YKL060C | 3.26 | 5.59E-4 | 0.07 | FBA1 | Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress |
YER126C | 3.19 | 7.14E-4 | 0.04 | NSA2 | Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA |
YMR235C | 3.15 | 8.14E-4 | 0.06 | RNA1 | GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport |