Deletion Strain | FD score | P-value | Gene | Gene Description |
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YBR114W | 5.99 | 1.03E-9 | RAD16 | Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex |
YDR150W | 5.70 | 5.98E-9 | NUM1 | Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex |
YJL178C | 5.57 | 1.27E-8 | ATG27 | Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site |
YDR284C | 5.22 | 8.84E-8 | DPP1 | Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism |
YOR072W_d | 5.21 | 9.32E-8 | YOR072W_d | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive |
YDR030C | 5.13 | 1.47E-7 | RAD28 | Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair |
YPR115W | 4.56 | 2.60E-6 | RGC1 | Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication |
YKL133C_p | 4.55 | 2.74E-6 | YKL133C_p | Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype) |
YGL109W_d | 4.48 | 3.70E-6 | YGL109W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C |
YPR084W_p | 4.48 | 3.81E-6 | YPR084W_p | Putative protein of unknown function |
YGL062W | 4.41 | 5.13E-6 | PYC1 | Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication |
YER019W | 4.32 | 7.66E-6 | ISC1 | Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance |
YBR194W | 4.27 | 9.91E-6 | AIM4 | Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress |
YPR179C | 4.26 | 1.04E-5 | HDA3 | Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p |
YGL049C | 4.07 | 2.31E-5 | TIF4632 | Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication |