Deletion Strain | FD score | P-value | Gene | Gene Description |
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YOR162C | 15.70 | 9.86E-56 | YRR1 | Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication |
YGL054C | 8.89 | 2.94E-19 | ERV14 | COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication |
YAL067W-A_p | 6.79 | 5.60E-12 | YAL067W-A_p | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
YER019W | 5.89 | 1.88E-9 | ISC1 | Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance |
YPL115C | 5.39 | 3.49E-8 | BEM3 | Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly |
YLR268W | 5.34 | 4.52E-8 | SEC22 | R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog |
YIR023W | 5.19 | 1.05E-7 | DAL81 | Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism |
YER087C-B | 5.12 | 1.52E-7 | SBH1 | Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p |
YPL236C | 5.01 | 2.76E-7 | ENV7 | Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16) |
YDR541C_p | 4.71 | 1.26E-6 | YDR541C_p | Putative dihydrokaempferol 4-reductase |
YLR334C_d | 4.63 | 1.82E-6 | YLR334C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here |
YER161C | 4.61 | 2.00E-6 | SPT2 | Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins |
YLR261C_d | 4.55 | 2.67E-6 | VPS63_d | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect |
YNL104C | 4.49 | 3.57E-6 | LEU4 | Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication |
YNL235C_d | 4.40 | 5.36E-6 | YNL235C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex |