Deletion Strain | FD score | P-value | Gene | Gene Description |
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YGR132C | 9.57 | 5.27E-22 | PHB1 | Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation |
YNR029C_p | 9.16 | 2.58E-20 | YNR029C_p | Putative protein of unknown function, deletion confers reduced fitness in saline |
YKR067W | 9.11 | 4.27E-20 | GPT2 | Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen |
YGR231C | 6.81 | 4.88E-12 | PHB2 | Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation |
YIR020C_p | 6.22 | 2.56E-10 | YIR020C_p | Protein of unknown function; mRNA identified as translated by ribosome profiling data |
YBL070C_d | 5.95 | 1.35E-9 | YBL070C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YFL053W | 5.79 | 3.61E-9 | DAK2 | Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation |
YJR033C | 5.70 | 6.15E-9 | RAV1 | Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate |
YNL325C | 5.53 | 1.57E-8 | FIG4 | Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain |
YIL162W | 5.00 | 2.89E-7 | SUC2 | Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively |
YCR034W | 4.97 | 3.38E-7 | FEN1 | Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication |
YLR224W_p | 4.88 | 5.22E-7 | YLR224W_p | F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene |
YCR079W | 4.71 | 1.27E-6 | PTC6 | Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase |
YGL031C | 4.51 | 3.17E-6 | RPL24A | Ribosomal 60S subunit protein L24A; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication |
YOR345C_d | 4.44 | 4.44E-6 | YOR345C_d | Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 |