Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YBL074C | 4.45 | 4.30E-6 | 0.35 | AAR2 | Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron |
YER104W | 4.22 | 1.23E-5 | 0.35 | RTT105 | Protein with a role in regulation of Ty1 transposition |
YBR140C | 4.19 | 1.38E-5 | 0.35 | IRA1 | GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication |
YHR058C | 4.17 | 1.50E-5 | 0.35 | MED6 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress |
YGR267C | 3.94 | 4.01E-5 | 0.35 | FOL2 | GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway |
YDR473C | 3.77 | 8.08E-5 | 0.35 | PRP3 | Splicing factor, component of the U4/U6-U5 snRNP complex |
YLR029C | 3.72 | 1.00E-4 | 0.35 | RPL15A | Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication |
YNL317W | 3.64 | 1.37E-4 | 0.35 | PFS2 | Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex |
YER136W | 3.62 | 1.47E-4 | 0.35 | GDI1 | GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins |
YLR002C | 3.27 | 5.32E-4 | 0.12 | NOC3 | Component of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing |
YDR082W | 3.16 | 7.98E-4 | 0.07 | STN1 | Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping |
YER003C | 3.08 | 0.00103 | 0.11 | PMI40 | Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation |
YFL039C | 2.97 | 0.00148 | 0.01 | ACT1 | Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions |
YOL040C | 2.96 | 0.00152 | 0.01 | RPS15 | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19 |
YGR156W | 2.95 | 0.00157 | 0.13 | PTI1 | Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64 |