1550-0330

4-bromo-6-[[[2-[(4-chlorophenyl)methyl]-1,3-benzoxazol-5-yl]amino]methylidene]-2-methoxycyclohexa-2,4-dien-1-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_561
Screen concentration 72.9 μM
Source ChemDiv (Drug-like library)
PubChem CID 6812934
SMILES COC1=CC(=CC(=CNC2=CC3=C(C=C2)OC(=N3)CC4=CC=C(C=C4)Cl)C1=O)Br
Standardized SMILES COc1cc(Br)cc(C=Nc2ccc3oc(Cc4ccc(Cl)cc4)nc3c2)c1O
Molecular weight 471.731
ALogP 4.39
H-bond donor count 1
H-bond acceptor count 5
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.57
% growth inhibition (Hom. pool) 2.26


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 6812934
Download HIP data (tab-delimited text)  (excel)
Gene:APC4(YDR118W)|FD-Score:-3.14|P-value:8.52E-4|Clearance:0||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress Gene:FRQ1(YDR373W)|FD-Score:3.69|P-value:1.13E-4|Clearance:0.07||SGD DESC:N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily Gene:IPP1(YBR011C)|FD-Score:-3.1|P-value:9.76E-4|Clearance:0||SGD DESC:Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase Gene:LSM5(YER146W)|FD-Score:4.51|P-value:3.20E-6|Clearance:0.54||SGD DESC:Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA Gene:NAT2(YGR147C)|FD-Score:3.71|P-value:1.02E-4|Clearance:0.02||SGD DESC:Protein with an apparent role in acetylation of N-terminal methionine residues Gene:PBN1(YCL052C)|FD-Score:3.9|P-value:4.74E-5|Clearance:0.01||SGD DESC:Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X Gene:PMI40(YER003C)|FD-Score:3.89|P-value:5.04E-5|Clearance:0.18||SGD DESC:Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation Gene:PRE1(YER012W)|FD-Score:3.13|P-value:8.64E-4|Clearance:0.08||SGD DESC:Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle Gene:PTI1(YGR156W)|FD-Score:4.57|P-value:2.42E-6|Clearance:0.54||SGD DESC:Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64 Gene:REB1(YBR049C)|FD-Score:3.98|P-value:3.52E-5|Clearance:0.07||SGD DESC:RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; REB1 has a paralog, NSI1, that arose from the whole genome duplication Gene:RMP1(YLR145W)|FD-Score:-4.14|P-value:1.72E-5|Clearance:0||SGD DESC:Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P Gene:ROT1(YMR200W)|FD-Score:3.62|P-value:1.45E-4|Clearance:0.11||SGD DESC:Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation Gene:RPT1(YKL145W)|FD-Score:3.51|P-value:2.21E-4|Clearance:0.38||SGD DESC:One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance Gene:APC4(YDR118W)|FD-Score:-3.14|P-value:8.52E-4|Clearance:0||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress Gene:FRQ1(YDR373W)|FD-Score:3.69|P-value:1.13E-4|Clearance:0.07||SGD DESC:N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily Gene:IPP1(YBR011C)|FD-Score:-3.1|P-value:9.76E-4|Clearance:0||SGD DESC:Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase Gene:LSM5(YER146W)|FD-Score:4.51|P-value:3.20E-6|Clearance:0.54||SGD DESC:Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA Gene:NAT2(YGR147C)|FD-Score:3.71|P-value:1.02E-4|Clearance:0.02||SGD DESC:Protein with an apparent role in acetylation of N-terminal methionine residues Gene:PBN1(YCL052C)|FD-Score:3.9|P-value:4.74E-5|Clearance:0.01||SGD DESC:Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X Gene:PMI40(YER003C)|FD-Score:3.89|P-value:5.04E-5|Clearance:0.18||SGD DESC:Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation Gene:PRE1(YER012W)|FD-Score:3.13|P-value:8.64E-4|Clearance:0.08||SGD DESC:Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle Gene:PTI1(YGR156W)|FD-Score:4.57|P-value:2.42E-6|Clearance:0.54||SGD DESC:Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64 Gene:REB1(YBR049C)|FD-Score:3.98|P-value:3.52E-5|Clearance:0.07||SGD DESC:RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; REB1 has a paralog, NSI1, that arose from the whole genome duplication Gene:RMP1(YLR145W)|FD-Score:-4.14|P-value:1.72E-5|Clearance:0||SGD DESC:Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P Gene:ROT1(YMR200W)|FD-Score:3.62|P-value:1.45E-4|Clearance:0.11||SGD DESC:Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation Gene:RPT1(YKL145W)|FD-Score:3.51|P-value:2.21E-4|Clearance:0.38||SGD DESC:One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 6812934
Download HOP data (tab-delimited text)  (excel)
Gene:APE1(YKL103C)|FD-Score:3.25|P-value:5.78E-4||SGD DESC:Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress Gene:ARA2(YMR041C)|FD-Score:-3.12|P-value:8.95E-4||SGD DESC:NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase Gene:ARR2(YPR200C)|FD-Score:3.15|P-value:8.19E-4||SGD DESC:Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p Gene:ARR3(YPR201W)|FD-Score:3.12|P-value:9.01E-4||SGD DESC:Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite Gene:ATP18(YML081C-A)|FD-Score:-3.61|P-value:1.54E-4||SGD DESC:Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms Gene:BMH2(YDR099W)|FD-Score:-4.09|P-value:2.17E-5||SGD DESC:14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress Gene:BSC2(YDR275W)|FD-Score:3.83|P-value:6.54E-5||SGD DESC:Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication Gene:BTS1(YPL069C)|FD-Score:6.23|P-value:2.26E-10||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:BUD14(YAR014C)|FD-Score:4.9|P-value:4.86E-7||SGD DESC:Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress Gene:BUD17(YNR027W)|FD-Score:-4.18|P-value:1.49E-5||SGD DESC:Putative pyridoxal kinase, a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK) Gene:CPR2(YHR057C)|FD-Score:3.33|P-value:4.30E-4||SGD DESC:Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway Gene:FRT1(YOR324C)|FD-Score:4.3|P-value:8.71E-6||SGD DESC:Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication Gene:HBT1(YDL223C)|FD-Score:3.55|P-value:1.95E-4||SGD DESC:Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis Gene:IGO2(YHR132W-A)|FD-Score:-3.57|P-value:1.78E-4||SGD DESC:Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo1p Gene:IRC7(YFR055W_p)|FD-Score:3.59|P-value:1.65E-4||SGD DESC:Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner Gene:KEL2(YGR238C)|FD-Score:3.28|P-value:5.23E-4||SGD DESC:Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate Gene:LEE1(YPL054W)|FD-Score:3.53|P-value:2.06E-4||SGD DESC:Zinc-finger protein of unknown function Gene:LHS1(YKL073W)|FD-Score:3.81|P-value:7.07E-5||SGD DESC:Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway Gene:LTV1(YKL143W)|FD-Score:3.52|P-value:2.14E-4||SGD DESC:Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature Gene:MHF1(YOL086W-A)|FD-Score:3.55|P-value:1.93E-4||SGD DESC:Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1 Gene:MOD5(YOR274W)|FD-Score:3.19|P-value:7.23E-4||SGD DESC:Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis Gene:MRPL40(YPL173W)|FD-Score:3.59|P-value:1.65E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL51(YPR100W)|FD-Score:3.21|P-value:6.75E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MSC1(YML128C)|FD-Score:-3.32|P-value:4.43E-4||SGD DESC:Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated Gene:NCA2(YPR155C)|FD-Score:3.14|P-value:8.47E-4||SGD DESC:Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p Gene:NUP157(YER105C)|FD-Score:3.64|P-value:1.37E-4||SGD DESC:Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and tethering of DNA to the nuclear periphery; both Nup170p and NUP157p are similar to human Nup155p; NUP157 has a paralog, NUP170, that arose from the whole genome duplication Gene:OCT1(YKL134C)|FD-Score:3.44|P-value:2.87E-4||SGD DESC:Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis Gene:PEP12(YOR036W)|FD-Score:4.09|P-value:2.12E-5||SGD DESC:Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin Gene:PIH1(YHR034C)|FD-Score:-3.15|P-value:8.05E-4||SGD DESC:Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II Gene:RIM101(YHL027W)|FD-Score:3.48|P-value:2.48E-4||SGD DESC:Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC Gene:RPL23A(YBL087C)|FD-Score:3.26|P-value:5.60E-4||SGD DESC:Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication Gene:RPS17B(YDR447C)|FD-Score:-3.99|P-value:3.34E-5||SGD DESC:Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:SHH3(YMR118C_p)|FD-Score:3.54|P-value:1.97E-4||SGD DESC:Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase Gene:SPE1(YKL184W)|FD-Score:-3.37|P-value:3.76E-4||SGD DESC:Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation Gene:SPO1(YNL012W)|FD-Score:5.25|P-value:7.68E-8||SGD DESC:Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B Gene:STE23(YLR389C)|FD-Score:-3.09|P-value:9.96E-4||SGD DESC:Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family Gene:SWI4(YER111C)|FD-Score:-3.75|P-value:8.74E-5||SGD DESC:DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p Gene:TGS1(YPL157W)|FD-Score:3.5|P-value:2.32E-4||SGD DESC:Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs Gene:TIM21(YGR033C)|FD-Score:-3.47|P-value:2.57E-4||SGD DESC:Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity Gene:UBP5(YER144C)|FD-Score:-4.99|P-value:3.04E-7||SGD DESC:Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck Gene:YAL004W(YAL004W_d)|FD-Score:3.35|P-value:4.03E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C Gene:YAP7(YOL028C)|FD-Score:3.78|P-value:7.76E-5||SGD DESC:Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication Gene:YBL094C(YBL094C_d)|FD-Score:-3.5|P-value:2.33E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W Gene:YDR095C(YDR095C_d)|FD-Score:-3.14|P-value:8.43E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YDR455C(YDR455C_d)|FD-Score:-3.72|P-value:1.01E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W Gene:YER121W(YER121W_p)|FD-Score:-3.4|P-value:3.34E-4||SGD DESC:Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy Gene:YGL010W(YGL010W_p)|FD-Score:-3.19|P-value:7.01E-4||SGD DESC:Putative protein of unknown function; YGL010W is not an essential gene Gene:YGL109W(YGL109W_d)|FD-Score:-3.13|P-value:8.69E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C Gene:YGR228W(YGR228W_d)|FD-Score:3.36|P-value:3.94E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C Gene:YIL055C(YIL055C_p)|FD-Score:4.82|P-value:7.17E-7||SGD DESC:Putative protein of unknown function Gene:YJR038C(YJR038C_d)|FD-Score:5.92|P-value:1.64E-9||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJR129C(YJR129C_p)|FD-Score:-4.28|P-value:9.20E-6||SGD DESC:Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YKL136W(YKL136W_d)|FD-Score:-3.75|P-value:8.90E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C Gene:YLL007C(YLL007C_p)|FD-Score:3.18|P-value:7.37E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene Gene:YLR211C(YLR211C_p)|FD-Score:3.62|P-value:1.50E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron Gene:YML084W(YML084W_d)|FD-Score:-3.25|P-value:5.70E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YML096W(YML096W_p)|FD-Score:-3.4|P-value:3.43E-4||SGD DESC:Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10 Gene:YNL067W-B(YNL067W-B_p)|FD-Score:-3.42|P-value:3.12E-4||SGD DESC:Putative protein of unknown function Gene:YNL226W(YNL226W_d)|FD-Score:5.7|P-value:6.10E-9||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C Gene:YNL295W(YNL295W_p)|FD-Score:3.54|P-value:1.98E-4||SGD DESC:Putative protein of unknown function Gene:YOR082C(YOR082C_d)|FD-Score:3.67|P-value:1.21E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W Gene:APE1(YKL103C)|FD-Score:3.25|P-value:5.78E-4||SGD DESC:Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress Gene:ARA2(YMR041C)|FD-Score:-3.12|P-value:8.95E-4||SGD DESC:NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase Gene:ARR2(YPR200C)|FD-Score:3.15|P-value:8.19E-4||SGD DESC:Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p Gene:ARR3(YPR201W)|FD-Score:3.12|P-value:9.01E-4||SGD DESC:Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite Gene:ATP18(YML081C-A)|FD-Score:-3.61|P-value:1.54E-4||SGD DESC:Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms Gene:BMH2(YDR099W)|FD-Score:-4.09|P-value:2.17E-5||SGD DESC:14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress Gene:BSC2(YDR275W)|FD-Score:3.83|P-value:6.54E-5||SGD DESC:Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication Gene:BTS1(YPL069C)|FD-Score:6.23|P-value:2.26E-10||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:BUD14(YAR014C)|FD-Score:4.9|P-value:4.86E-7||SGD DESC:Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress Gene:BUD17(YNR027W)|FD-Score:-4.18|P-value:1.49E-5||SGD DESC:Putative pyridoxal kinase, a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK) Gene:CPR2(YHR057C)|FD-Score:3.33|P-value:4.30E-4||SGD DESC:Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway Gene:FRT1(YOR324C)|FD-Score:4.3|P-value:8.71E-6||SGD DESC:Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication Gene:HBT1(YDL223C)|FD-Score:3.55|P-value:1.95E-4||SGD DESC:Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis Gene:IGO2(YHR132W-A)|FD-Score:-3.57|P-value:1.78E-4||SGD DESC:Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo1p Gene:IRC7(YFR055W_p)|FD-Score:3.59|P-value:1.65E-4||SGD DESC:Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner Gene:KEL2(YGR238C)|FD-Score:3.28|P-value:5.23E-4||SGD DESC:Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate Gene:LEE1(YPL054W)|FD-Score:3.53|P-value:2.06E-4||SGD DESC:Zinc-finger protein of unknown function Gene:LHS1(YKL073W)|FD-Score:3.81|P-value:7.07E-5||SGD DESC:Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway Gene:LTV1(YKL143W)|FD-Score:3.52|P-value:2.14E-4||SGD DESC:Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature Gene:MHF1(YOL086W-A)|FD-Score:3.55|P-value:1.93E-4||SGD DESC:Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1 Gene:MOD5(YOR274W)|FD-Score:3.19|P-value:7.23E-4||SGD DESC:Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis Gene:MRPL40(YPL173W)|FD-Score:3.59|P-value:1.65E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL51(YPR100W)|FD-Score:3.21|P-value:6.75E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MSC1(YML128C)|FD-Score:-3.32|P-value:4.43E-4||SGD DESC:Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated Gene:NCA2(YPR155C)|FD-Score:3.14|P-value:8.47E-4||SGD DESC:Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p Gene:NUP157(YER105C)|FD-Score:3.64|P-value:1.37E-4||SGD DESC:Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and tethering of DNA to the nuclear periphery; both Nup170p and NUP157p are similar to human Nup155p; NUP157 has a paralog, NUP170, that arose from the whole genome duplication Gene:OCT1(YKL134C)|FD-Score:3.44|P-value:2.87E-4||SGD DESC:Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis Gene:PEP12(YOR036W)|FD-Score:4.09|P-value:2.12E-5||SGD DESC:Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin Gene:PIH1(YHR034C)|FD-Score:-3.15|P-value:8.05E-4||SGD DESC:Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II Gene:RIM101(YHL027W)|FD-Score:3.48|P-value:2.48E-4||SGD DESC:Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC Gene:RPL23A(YBL087C)|FD-Score:3.26|P-value:5.60E-4||SGD DESC:Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication Gene:RPS17B(YDR447C)|FD-Score:-3.99|P-value:3.34E-5||SGD DESC:Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:SHH3(YMR118C_p)|FD-Score:3.54|P-value:1.97E-4||SGD DESC:Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase Gene:SPE1(YKL184W)|FD-Score:-3.37|P-value:3.76E-4||SGD DESC:Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation Gene:SPO1(YNL012W)|FD-Score:5.25|P-value:7.68E-8||SGD DESC:Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B Gene:STE23(YLR389C)|FD-Score:-3.09|P-value:9.96E-4||SGD DESC:Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family Gene:SWI4(YER111C)|FD-Score:-3.75|P-value:8.74E-5||SGD DESC:DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p Gene:TGS1(YPL157W)|FD-Score:3.5|P-value:2.32E-4||SGD DESC:Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs Gene:TIM21(YGR033C)|FD-Score:-3.47|P-value:2.57E-4||SGD DESC:Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity Gene:UBP5(YER144C)|FD-Score:-4.99|P-value:3.04E-7||SGD DESC:Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck Gene:YAL004W(YAL004W_d)|FD-Score:3.35|P-value:4.03E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C Gene:YAP7(YOL028C)|FD-Score:3.78|P-value:7.76E-5||SGD DESC:Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication Gene:YBL094C(YBL094C_d)|FD-Score:-3.5|P-value:2.33E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W Gene:YDR095C(YDR095C_d)|FD-Score:-3.14|P-value:8.43E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YDR455C(YDR455C_d)|FD-Score:-3.72|P-value:1.01E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W Gene:YER121W(YER121W_p)|FD-Score:-3.4|P-value:3.34E-4||SGD DESC:Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy Gene:YGL010W(YGL010W_p)|FD-Score:-3.19|P-value:7.01E-4||SGD DESC:Putative protein of unknown function; YGL010W is not an essential gene Gene:YGL109W(YGL109W_d)|FD-Score:-3.13|P-value:8.69E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C Gene:YGR228W(YGR228W_d)|FD-Score:3.36|P-value:3.94E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C Gene:YIL055C(YIL055C_p)|FD-Score:4.82|P-value:7.17E-7||SGD DESC:Putative protein of unknown function Gene:YJR038C(YJR038C_d)|FD-Score:5.92|P-value:1.64E-9||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJR129C(YJR129C_p)|FD-Score:-4.28|P-value:9.20E-6||SGD DESC:Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YKL136W(YKL136W_d)|FD-Score:-3.75|P-value:8.90E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C Gene:YLL007C(YLL007C_p)|FD-Score:3.18|P-value:7.37E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene Gene:YLR211C(YLR211C_p)|FD-Score:3.62|P-value:1.50E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron Gene:YML084W(YML084W_d)|FD-Score:-3.25|P-value:5.70E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YML096W(YML096W_p)|FD-Score:-3.4|P-value:3.43E-4||SGD DESC:Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10 Gene:YNL067W-B(YNL067W-B_p)|FD-Score:-3.42|P-value:3.12E-4||SGD DESC:Putative protein of unknown function Gene:YNL226W(YNL226W_d)|FD-Score:5.7|P-value:6.10E-9||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C Gene:YNL295W(YNL295W_p)|FD-Score:3.54|P-value:1.98E-4||SGD DESC:Putative protein of unknown function Gene:YOR082C(YOR082C_d)|FD-Score:3.67|P-value:1.21E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGR156W4.572.42E-60.54PTI1Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
YER146W4.513.20E-60.54LSM5Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YBR049C3.983.52E-50.07REB1RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; REB1 has a paralog, NSI1, that arose from the whole genome duplication
YCL052C3.904.74E-50.01PBN1Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X
YER003C3.895.04E-50.18PMI40Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
YGR147C3.711.02E-40.02NAT2Protein with an apparent role in acetylation of N-terminal methionine residues
YDR373W3.691.13E-40.07FRQ1N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily
YMR200W3.621.45E-40.11ROT1Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation
YKL145W3.512.21E-40.38RPT1One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance
YER012W3.138.64E-40.08PRE1Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
YKL186C3.050.001140.04MTR2mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA
YOL097C3.010.001290.02WRS1Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA
YNL287W2.990.001380.07SEC21Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
YHR196W2.920.001730.04UTP9Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YNL172W2.880.001980.09APC1Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YPL069C6.232.26E-10BTS1Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic
YJR038C_d5.921.64E-9YJR038C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL226W_d5.706.10E-9YNL226W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C
YNL012W5.257.68E-8SPO1Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B
YAR014C4.904.86E-7BUD14Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress
YIL055C_p4.827.17E-7YIL055C_pPutative protein of unknown function
YOR324C4.308.71E-6FRT1Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication
YOR036W4.092.12E-5PEP12Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
YDR275W3.836.54E-5BSC2Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication
YKL073W3.817.07E-5LHS1Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway
YOL028C3.787.76E-5YAP7Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication
YOR082C_d3.671.21E-4YOR082C_dDubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W
YER105C3.641.37E-4NUP157Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and tethering of DNA to the nuclear periphery; both Nup170p and NUP157p are similar to human Nup155p; NUP157 has a paralog, NUP170, that arose from the whole genome duplication
YLR211C_p3.621.50E-4YLR211C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron
YPL173W3.591.65E-4MRPL40Mitochondrial ribosomal protein of the large subunit

GO enrichment analysis for SGTC_561
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1031.78E-15SGTC_8360330-0104 1.4 μMChemDiv (Drug-like library)464948200.0609756
0.0782.33E-9SGTC_1752st044819 83.0 μMTimTec (Natural product derivative library)4412090.0487805
0.0731.97E-8SGTC_32839109332 35.8 μMChembridge (Drug-like library)170272810.0824742DNA intercalators
0.0732.20E-8SGTC_31059121040 49.5 μMChembridge (Drug-like library)414489070.0909091
0.0722.83E-8SGTC_4711-acyl-paf 4.0 μMICCB bioactive library167593670.029703DNA intercalators
0.0723.07E-8SGTC_6880527-0193 473.0 μMChemDiv (Drug-like library)40071540.0777778fatty acid desaturase (OLE1)
0.0681.69E-7SGTC_1764st044502 93.5 μMTimTec (Natural product derivative library)84070.0379747
0.0647.68E-7SGTC_1892st058411 7.4 μMTimTec (Natural product derivative library)39347380.156627
0.0647.86E-7SGTC_24875918373 44.0 μMMiscellaneous28762790.0606061
0.0649.21E-7SGTC_482fipronil 114.0 μMICCB bioactive library33520.0638298
0.0612.26E-6SGTC_2961222-0039 74.9 μMChemDiv (Drug-like library)59841760.113924
0.0604.31E-6SGTC_14153966-0071 78.1 μMChemDiv (Drug-like library)28931850.0779221DNA intercalators
0.0604.43E-6SGTC_24835729050 27.2 μMMiscellaneous28651800.0707071
0.0595.37E-6SGTC_7273032-0951 202.0 μMChemDiv (Drug-like library)36528360.102273
0.0587.91E-6SGTC_30409091894 49.5 μMChembridge (Drug-like library)252369660.0752688DNA intercalators

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_5741315-039740 μM0.5479456794277ChemDiv (Drug-like library)437.285984.17615
SGTC_170960-027649.81 μM0.4871796821114ChemDiv (Drug-like library)471.731044.70315
SGTC_6941315-043843.2 μM0.4864866793154ChemDiv (Drug-like library)378.80843.90215
SGTC_643k048-010628.4 μM0.4696976763920ChemDiv (Drug-like library)419.49573.65213RSC & ERG11
SGTC_560957-036583.25 μM0.4666676752360ChemDiv (Drug-like library)453.285383.67416Golgi
SGTC_5860957-02658.15 μM0.4615386752309ChemDiv (Drug-like library)388.41592.83726cell wall
SGTC_7571066-0008322 μM0.4415586842497ChemDiv (Drug-like library)596.15644.09815Golgi
SGTC_3111315-013658 μM0.436626759207ChemDiv (Drug-like library)372.6166833.45814
SGTC_9711315-038426.7 μM0.4146346769120ChemDiv (Drug-like library)451.312564.52515cell wall signaling
SGTC_6841140-0066328 μM0.3647066813534ChemDiv (Drug-like library)406.861564.73715Golgi