Deletion Strain | FD score | P-value | Gene | Gene Description |
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YDL202W | 6.50 | 4.04E-11 | MRPL11 | Mitochondrial ribosomal protein of the large subunit |
YER053C-A_p | 5.78 | 3.81E-9 | YER053C-A_p | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress |
YLL018C-A | 5.39 | 3.53E-8 | COX19 | Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs |
YMR271C | 5.36 | 4.17E-8 | URA10 | Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication |
YMR052C-A_d | 5.17 | 1.15E-7 | YMR052C-A_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YOR198C | 5.14 | 1.41E-7 | BFR1 | Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity |
YKL068W | 5.06 | 2.14E-7 | NUP100 | FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; homologous to Nup116p |
YER039C | 4.76 | 9.84E-7 | HVG1 | Protein of unknown function, has homology to Vrg4p |
YPR062W | 4.72 | 1.19E-6 | FCY1 | Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) |
YBL087C | 4.71 | 1.23E-6 | RPL23A | Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication |
YMR251W-A | 4.63 | 1.80E-6 | HOR7 | Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication |
YLR131C | 4.62 | 1.95E-6 | ACE2 | Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication |
YGR148C | 4.49 | 3.59E-6 | RPL24B | Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication |
YLL047W_d | 4.45 | 4.20E-6 | YLL047W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1 |
YOR229W | 4.43 | 4.71E-6 | WTM2 | Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats |