Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YDR164C | 4.50 | 3.45E-6 | 0.78 | SEC1 | Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function |
YDR362C | 3.72 | 9.94E-5 | 0.19 | TFC6 | One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110 |
YJL005W | 3.53 | 2.05E-4 | 0.47 | CYR1 | Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation |
YKL165C | 3.06 | 0.00109 | 0.00 | MCD4 | Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes |
YNR035C | 3.06 | 0.00110 | 0.08 | ARC35 | Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin |
YKL042W | 2.98 | 0.00146 | 0.04 | SPC42 | Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane |
YPR085C | 2.94 | 0.00164 | 0.10 | ASA1 | Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1 |
YNL038W | 2.84 | 0.00225 | 0.05 | GPI15 | Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein |
YDR081C | 2.80 | 0.00259 | 0.01 | PDC2 | Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions |
YDL016C_d | 2.79 | 0.00266 | 0.02 | YDL016C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication |
YFL022C | 2.77 | 0.00281 | 0.01 | FRS2 | Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar |
YLR008C | 2.75 | 0.00294 | 0.04 | PAM18 | Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p |
YPL007C | 2.71 | 0.00336 | 0.03 | TFC8 | One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90 |
YJL085W | 2.68 | 0.00364 | 0.10 | EXO70 | Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress |
YGR267C | 2.58 | 0.00492 | 0.17 | FOL2 | GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway |