| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YKR019C | 6.37 | 9.36E-11 | IRS4 | EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication |
| YLR371W | 6.05 | 7.13E-10 | ROM2 | GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p |
| YGL005C | 5.78 | 3.64E-9 | COG7 | Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments |
| YLR262C | 5.56 | 1.32E-8 | YPT6 | Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 |
| YOR162C | 5.01 | 2.75E-7 | YRR1 | Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication |
| YKL029C | 4.44 | 4.50E-6 | MAE1 | Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids |
| YLR296W_d | 4.36 | 6.59E-6 | YLR296W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| YML071C | 4.32 | 7.84E-6 | COG8 | Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments |
| YJL155C | 4.22 | 1.20E-5 | FBP26 | Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress |
| YER184C_p | 4.19 | 1.37E-5 | YER184C_p | Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source |
| YMR274C | 4.14 | 1.77E-5 | RCE1 | Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone |
| YMR052W | 3.92 | 4.42E-5 | FAR3 | Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress |
| YMR182C | 3.84 | 6.17E-5 | RGM1 | Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication |
| YER183C | 3.82 | 6.70E-5 | FAU1 | 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis |
| YPL111W | 3.79 | 7.50E-5 | CAR1 | Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance |
