4299-0174

5-[(5-chloro-2-hydroxy-3-methoxyphenyl)methylidene]-1,3-diethyl-2-sulfanylidene-1,3-diazinane-4,6-dione

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_591
Screen concentration 154.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 5509088
SMILES CCN1C(=O)C(=CC2=CC(=CC(=C2O)OC)Cl)C(=O)N(C1=S)CC
Standardized SMILES CCN1C(=S)N(CC)C(=O)C(=Cc2cc(Cl)cc(OC)c2O)C1=O
Molecular weight 368.8352
ALogP 3.28
H-bond donor count 1
H-bond acceptor count 5
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 12.87
% growth inhibition (Hom. pool) 8.51


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 5509088
Download HIP data (tab-delimited text)  (excel)
Gene:ARP7(YPR034W)|FD-Score:4.33|P-value:7.40E-6|Clearance:0.1||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:DOP1(YDR141C)|FD-Score:-3.22|P-value:6.51E-4|Clearance:0||SGD DESC:Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies Gene:HSH49(YOR319W)|FD-Score:4.23|P-value:1.16E-5|Clearance:0.21||SGD DESC:U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM) Gene:LSM4(YER112W)|FD-Score:-3.39|P-value:3.50E-4|Clearance:0||SGD DESC:Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress Gene:RHO1(YPR165W)|FD-Score:5.07|P-value:1.96E-7|Clearance:0.74||SGD DESC:GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) Gene:RPA43(YOR340C)|FD-Score:4.02|P-value:2.94E-5|Clearance:0.39||SGD DESC:RNA polymerase I subunit A43 Gene:RPC11(YDR045C)|FD-Score:-3.59|P-value:1.65E-4|Clearance:0||SGD DESC:RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS Gene:RSC58(YLR033W)|FD-Score:3.36|P-value:3.91E-4|Clearance:0.29||SGD DESC:Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance Gene:TAF11(YML015C)|FD-Score:3.63|P-value:1.41E-4|Clearance:0.27||SGD DESC:TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors Gene:ARP7(YPR034W)|FD-Score:4.33|P-value:7.40E-6|Clearance:0.1||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:DOP1(YDR141C)|FD-Score:-3.22|P-value:6.51E-4|Clearance:0||SGD DESC:Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies Gene:HSH49(YOR319W)|FD-Score:4.23|P-value:1.16E-5|Clearance:0.21||SGD DESC:U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM) Gene:LSM4(YER112W)|FD-Score:-3.39|P-value:3.50E-4|Clearance:0||SGD DESC:Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress Gene:RHO1(YPR165W)|FD-Score:5.07|P-value:1.96E-7|Clearance:0.74||SGD DESC:GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) Gene:RPA43(YOR340C)|FD-Score:4.02|P-value:2.94E-5|Clearance:0.39||SGD DESC:RNA polymerase I subunit A43 Gene:RPC11(YDR045C)|FD-Score:-3.59|P-value:1.65E-4|Clearance:0||SGD DESC:RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS Gene:RSC58(YLR033W)|FD-Score:3.36|P-value:3.91E-4|Clearance:0.29||SGD DESC:Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance Gene:TAF11(YML015C)|FD-Score:3.63|P-value:1.41E-4|Clearance:0.27||SGD DESC:TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 5509088
Download HOP data (tab-delimited text)  (excel)
Gene:AMS1(YGL156W)|FD-Score:3.36|P-value:3.95E-4||SGD DESC:Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway Gene:APE4(YHR113W)|FD-Score:-3.13|P-value:8.70E-4||SGD DESC:Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole; CVT pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family Gene:BAS1(YKR099W)|FD-Score:-3.75|P-value:8.82E-5||SGD DESC:Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes Gene:CAR2(YLR438W)|FD-Score:4.42|P-value:4.95E-6||SGD DESC:L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress Gene:ECT1(YGR007W)|FD-Score:3.3|P-value:4.88E-4||SGD DESC:Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases Gene:FUI1(YBL042C)|FD-Score:3.89|P-value:5.09E-5||SGD DESC:High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress Gene:GOT1(YMR292W)|FD-Score:3.47|P-value:2.58E-4||SGD DESC:Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition Gene:GTR1(YML121W)|FD-Score:3.57|P-value:1.75E-4||SGD DESC:Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB Gene:HTA2(YBL003C)|FD-Score:3.97|P-value:3.64E-5||SGD DESC:Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p Gene:IRS4(YKR019C)|FD-Score:5.28|P-value:6.50E-8||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:ITR2(YOL103W)|FD-Score:3.36|P-value:3.85E-4||SGD DESC:Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively Gene:LHS1(YKL073W)|FD-Score:3.41|P-value:3.19E-4||SGD DESC:Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway Gene:MMS2(YGL087C)|FD-Score:-3.09|P-value:9.84E-4||SGD DESC:Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress Gene:MSN1(YOL116W)|FD-Score:3.94|P-value:4.02E-5||SGD DESC:Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress Gene:NMD2(YHR077C)|FD-Score:4|P-value:3.19E-5||SGD DESC:Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance Gene:NUT1(YGL151W)|FD-Score:3.13|P-value:8.85E-4||SGD DESC:Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription Gene:PET18(YCR020C)|FD-Score:3.09|P-value:9.86E-4||SGD DESC:Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin Gene:RGD2(YFL047W)|FD-Score:5.21|P-value:9.66E-8||SGD DESC:GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:RPL24B(YGR148C)|FD-Score:-3.47|P-value:2.58E-4||SGD DESC:Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication Gene:RTC1(YOL138C)|FD-Score:3.32|P-value:4.45E-4||SGD DESC:Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif Gene:SAC6(YDR129C)|FD-Score:4.83|P-value:6.71E-7||SGD DESC:Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:SLH1(YGR271W)|FD-Score:4.18|P-value:1.44E-5||SGD DESC:Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses Gene:SRO77(YBL106C)|FD-Score:3.46|P-value:2.66E-4||SGD DESC:Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication Gene:TLG2(YOL018C)|FD-Score:3.36|P-value:3.86E-4||SGD DESC:Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16) Gene:VPS51(YKR020W)|FD-Score:4.1|P-value:2.09E-5||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p Gene:YER186C(YER186C_p)|FD-Score:3.33|P-value:4.28E-4||SGD DESC:Putative protein of unknown function Gene:YGR228W(YGR228W_d)|FD-Score:4.77|P-value:9.05E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C Gene:YHL037C(YHL037C_d)|FD-Score:-3.32|P-value:4.57E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR108C(YLR108C_p)|FD-Score:-4.74|P-value:1.04E-6||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication Gene:YLR236C(YLR236C_d)|FD-Score:3.39|P-value:3.50E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR460C(YLR460C_p)|FD-Score:3.71|P-value:1.03E-4||SGD DESC:Member of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine Gene:YOL164W-A(YOL164W-A_p)|FD-Score:3.65|P-value:1.34E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YOR314W(YOR314W_d)|FD-Score:3.43|P-value:3.04E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:AMS1(YGL156W)|FD-Score:3.36|P-value:3.95E-4||SGD DESC:Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway Gene:APE4(YHR113W)|FD-Score:-3.13|P-value:8.70E-4||SGD DESC:Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole; CVT pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family Gene:BAS1(YKR099W)|FD-Score:-3.75|P-value:8.82E-5||SGD DESC:Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes Gene:CAR2(YLR438W)|FD-Score:4.42|P-value:4.95E-6||SGD DESC:L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress Gene:ECT1(YGR007W)|FD-Score:3.3|P-value:4.88E-4||SGD DESC:Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases Gene:FUI1(YBL042C)|FD-Score:3.89|P-value:5.09E-5||SGD DESC:High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress Gene:GOT1(YMR292W)|FD-Score:3.47|P-value:2.58E-4||SGD DESC:Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition Gene:GTR1(YML121W)|FD-Score:3.57|P-value:1.75E-4||SGD DESC:Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB Gene:HTA2(YBL003C)|FD-Score:3.97|P-value:3.64E-5||SGD DESC:Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p Gene:IRS4(YKR019C)|FD-Score:5.28|P-value:6.50E-8||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:ITR2(YOL103W)|FD-Score:3.36|P-value:3.85E-4||SGD DESC:Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively Gene:LHS1(YKL073W)|FD-Score:3.41|P-value:3.19E-4||SGD DESC:Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway Gene:MMS2(YGL087C)|FD-Score:-3.09|P-value:9.84E-4||SGD DESC:Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress Gene:MSN1(YOL116W)|FD-Score:3.94|P-value:4.02E-5||SGD DESC:Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress Gene:NMD2(YHR077C)|FD-Score:4|P-value:3.19E-5||SGD DESC:Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance Gene:NUT1(YGL151W)|FD-Score:3.13|P-value:8.85E-4||SGD DESC:Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription Gene:PET18(YCR020C)|FD-Score:3.09|P-value:9.86E-4||SGD DESC:Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin Gene:RGD2(YFL047W)|FD-Score:5.21|P-value:9.66E-8||SGD DESC:GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:RPL24B(YGR148C)|FD-Score:-3.47|P-value:2.58E-4||SGD DESC:Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication Gene:RTC1(YOL138C)|FD-Score:3.32|P-value:4.45E-4||SGD DESC:Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif Gene:SAC6(YDR129C)|FD-Score:4.83|P-value:6.71E-7||SGD DESC:Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:SLH1(YGR271W)|FD-Score:4.18|P-value:1.44E-5||SGD DESC:Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses Gene:SRO77(YBL106C)|FD-Score:3.46|P-value:2.66E-4||SGD DESC:Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication Gene:TLG2(YOL018C)|FD-Score:3.36|P-value:3.86E-4||SGD DESC:Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16) Gene:VPS51(YKR020W)|FD-Score:4.1|P-value:2.09E-5||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p Gene:YER186C(YER186C_p)|FD-Score:3.33|P-value:4.28E-4||SGD DESC:Putative protein of unknown function Gene:YGR228W(YGR228W_d)|FD-Score:4.77|P-value:9.05E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C Gene:YHL037C(YHL037C_d)|FD-Score:-3.32|P-value:4.57E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR108C(YLR108C_p)|FD-Score:-4.74|P-value:1.04E-6||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication Gene:YLR236C(YLR236C_d)|FD-Score:3.39|P-value:3.50E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR460C(YLR460C_p)|FD-Score:3.71|P-value:1.03E-4||SGD DESC:Member of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine Gene:YOL164W-A(YOL164W-A_p)|FD-Score:3.65|P-value:1.34E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YOR314W(YOR314W_d)|FD-Score:3.43|P-value:3.04E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YPR165W5.071.96E-70.74RHO1GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
YPR034W4.337.40E-60.10ARP7Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YOR319W4.231.16E-50.21HSH49U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)
YOR340C4.022.94E-50.39RPA43RNA polymerase I subunit A43
YML015C3.631.41E-40.27TAF11TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors
YLR033W3.363.91E-40.29RSC58Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
YDR052C3.070.001080.20DBF4Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress
YLR397C2.870.002050.01AFG2ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; releases Rlp24p from purified pre-60S particles in vitro; may be involved in degradation of aberrant mRNAs
YKL022C2.860.002120.20CDC16Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation
YHR007C2.660.003850.05ERG11Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p
YKL173W2.610.004490.02SNU114GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2
YOR075W2.590.004740.14UFE1t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER
YGL111W2.460.006950.01NSA1Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
YJR076C2.450.007050.04CDC11Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells
YFL037W2.410.007950.06TUB2Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YKR019C5.286.50E-8IRS4EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
YFL047W5.219.66E-8RGD2GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress
YDR129C4.836.71E-7SAC6Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress
YGR228W_d4.779.05E-7YGR228W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C
YLR438W4.424.95E-6CAR2L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress
YGR271W4.181.44E-5SLH1Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses
YKR020W4.102.09E-5VPS51Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p
YHR077C4.003.19E-5NMD2Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance
YBL003C3.973.64E-5HTA2Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YOL116W3.944.02E-5MSN1Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress
YBL042C3.895.09E-5FUI1High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress
YLR460C_p3.711.03E-4YLR460C_pMember of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine
YOL164W-A_p3.651.34E-4YOL164W-A_pPutative protein of unknown function; identified by fungal homology and RT-PCR
YML121W3.571.75E-4GTR1Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
YMR292W3.472.58E-4GOT1Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition

GO enrichment analysis for SGTC_591
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1491.12E-30SGTC_590k048-0076 22.4 μMChemDiv (Drug-like library)68328140.144928RSC & ERG11
0.1491.46E-30SGTC_32859112818 20.9 μMChembridge (Drug-like library)170179470.166667cell wall
0.1423.83E-28SGTC_33229139058 2.1 μMChembridge (Drug-like library)49089260.0697674cell wall
0.1411.03E-27SGTC_21095483026 200.0 μMChembridge (Fragment library)7593350.0967742RSC complex & mRNA processing
0.1373.46E-26SGTC_33509150499 3.6 μMChembridge (Drug-like library)49109960.0555556cell wall
0.1376.15E-26SGTC_560957-0365 83.2 μMChemDiv (Drug-like library)67523600.202532Golgi
0.1291.79E-23SGTC_33319141060 2.0 μMChembridge (Drug-like library)49065670.0833333cell wall
0.1261.90E-22SGTC_7830848-0141 92.7 μMChemDiv (Drug-like library)67550760.121622RSC & ERG11
0.1262.14E-22SGTC_643k048-0106 28.4 μMChemDiv (Drug-like library)67639200.242424RSC & ERG11
0.1226.27E-21SGTC_4300958-0115 16.4 μMChemDiv (Drug-like library)68331800.135802
0.1211.02E-20SGTC_185k048-0037 25.5 μMChemDiv (Drug-like library)68275890.121622RSC & ERG11
0.1171.69E-19SGTC_9701315-0089 19.5 μMChemDiv (Drug-like library)68110830.121951RSC & ERG11
0.1163.09E-19SGTC_3111315-0136 58.0 μMChemDiv (Drug-like library)67592070.225352
0.1128.04E-18SGTC_21866124449 200.0 μMChembridge (Fragment library)38341820.0519481RSC complex & mRNA processing
0.1093.99E-17SGTC_5660958-0068 16.5 μMChemDiv (Drug-like library)68153650.109756RSC & ERG11

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_8900929-000647.2 μM0.3064521378169ChemDiv (Drug-like library)267.324062.58325
SGTC_23369001819198.65 μM0.2909092989602Chembridge (Fragment library)209.629021.88902heme biosynthesis & mitochondrial translocase
SGTC_1565sinapyl alcohol95.1 μM0.2830195280507TimTec (Pure natural product library)210.226461.41824
SGTC_2561acetosyringone100 μM0.2745117198Microsource (Natural product library)196.199881.29514
SGTC_12860929-0070131 μM0.2741941420408ChemDiv (Drug-like library)251.258461.68325
SGTC_8191013-025827.7 μM0.2714295753198ChemDiv (Drug-like library)390.90695.13415
SGTC_2433560787427.82 μM0.2714292252428Miscellaneous374.84134.23515
SGTC_712r015-000980.6 μM0.2586216813872ChemDiv (Drug-like library)342.38898-0.25426
SGTC_24625162487171.77 μM0.2539682259986Miscellaneous239.313962.79104
SGTC_5611550-033072.9 μM0.2531656812934ChemDiv (Drug-like library)471.731044.38915