Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YDL029W | 7.59 | 1.63E-14 | 2.55 | ARP2 | Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity |
YBR190W_d | 5.04 | 2.31E-7 | 0.79 | YBR190W_d | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W |
YLR026C | 4.26 | 1.04E-5 | 0.15 | SED5 | cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins |
YMR220W | 4.10 | 2.04E-5 | 0.16 | ERG8 | Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate |
YLR340W | 3.94 | 4.06E-5 | 0.03 | RPP0 | Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10 |
YKR025W | 3.91 | 4.54E-5 | 0.01 | RPC37 | RNA polymerase III subunit C37 |
YHR069C | 3.91 | 4.68E-5 | 0.13 | RRP4 | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2) |
YPL228W | 3.78 | 7.98E-5 | 0.03 | CET1 | Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide |
YBR257W | 3.74 | 9.15E-5 | 0.07 | POP4 | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P |
YLR458W_d | 3.67 | 1.21E-4 | 0.03 | YLR458W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis |
YJL050W | 3.64 | 1.36E-4 | 0.01 | MTR4 | ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing |
YOR176W | 3.63 | 1.39E-4 | 0.03 | HEM15 | Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway |
YBR265W | 3.61 | 1.56E-4 | 0.10 | TSC10 | 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family |
YNL152W | 3.50 | 2.32E-4 | 0.03 | INN1 | Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis |
YNL113W | 3.47 | 2.63E-4 | 0.06 | RPC19 | RNA polymerase subunit AC19, common to RNA polymerases I and III |