Deletion Strain | FD score | P-value | Gene | Gene Description |
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YNL140C_p | 13.50 | 9.08E-42 | YNL140C_p | Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C |
YPL069C | 8.47 | 1.21E-17 | BTS1 | Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic |
YMR056C | 8.38 | 2.69E-17 | AAC1 | Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress |
YOR243C | 5.84 | 2.63E-9 | PUS7 | Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria |
YBR028C | 5.69 | 6.51E-9 | YPK3 | An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner |
YNR025C_d | 5.29 | 6.13E-8 | YNR025C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase |
YML062C | 4.70 | 1.28E-6 | MFT1 | Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance |
YLR144C | 4.66 | 1.61E-6 | ACF2 | Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress |
YDR357C_p | 4.51 | 3.22E-6 | CNL1_p | Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |
YLR052W | 4.47 | 3.99E-6 | IES3 | Subunit of the INO80 chromatin remodeling complex |
YOR235W_d | 4.11 | 1.98E-5 | IRC13_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci |
YOR078W | 4.07 | 2.37E-5 | BUD21 | Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern |
YMR083W | 4.05 | 2.54E-5 | ADH3 | Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production |
YMR070W | 3.91 | 4.64E-5 | MOT3 | Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion |
YJR021C | 3.91 | 4.68E-5 | REC107 | Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation |