Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YHR107C | 4.95 | 3.70E-7 | 0.74 | CDC12 | Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells |
YOR210W | 4.21 | 1.26E-5 | 0.58 | RPB10 | RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III |
YJR064W | 3.64 | 1.39E-4 | 0.06 | CCT5 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
YHR069C | 3.58 | 1.73E-4 | 0.06 | RRP4 | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2) |
YLR275W | 3.52 | 2.19E-4 | 0.18 | SMD2 | Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2 |
YPL235W | 3.34 | 4.20E-4 | 0.09 | RVB2 | ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly |
YDR280W | 3.25 | 5.81E-4 | 0.05 | RRP45 | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress |
YMR113W | 3.19 | 7.01E-4 | 0.01 | FOL3 | Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis |
YDL132W | 3.18 | 7.37E-4 | 0.05 | CDC53 | Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation |
YDR113C | 3.13 | 8.69E-4 | 0.08 | PDS1 | Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation |
YER104W | 3.05 | 0.00115 | 0.01 | RTT105 | Protein with a role in regulation of Ty1 transposition |
YPL238C_d | 3.03 | 0.00121 | 0.07 | YPL238C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W |
YJL109C | 2.96 | 0.00152 | 0.00 | UTP10 | Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance |
YDR212W | 2.96 | 0.00153 | 0.02 | TCP1 | Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein |
YER025W | 2.94 | 0.00162 | 0.12 | GCD11 | Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met |