Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YHR007C | 7.13 | 4.87E-13 | 1.01 | ERG11 | Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p |
YPR034W | 6.12 | 4.65E-10 | 0.94 | ARP7 | Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation |
YPR165W | 5.18 | 1.11E-7 | 0.98 | RHO1 | GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) |
YLR033W | 4.20 | 1.36E-5 | 0.21 | RSC58 | Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance |
YLR197W | 3.98 | 3.41E-5 | 0.02 | NOP56 | Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects |
YOR224C | 3.96 | 3.77E-5 | 0.24 | RPB8 | RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III |
YDR429C | 3.72 | 9.99E-5 | 0.02 | TIF35 | eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation |
YCR052W | 3.70 | 1.09E-4 | 0.01 | RSC6 | Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p |
YIL048W | 3.68 | 1.15E-4 | 0.02 | NEO1 | Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus |
YBL026W | 3.66 | 1.27E-4 | 0.08 | LSM2 | Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress |
YDL196W_d | 3.58 | 1.71E-4 | 0.14 | YDL196W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 |
YOR151C | 3.45 | 2.83E-4 | 0.23 | RPB2 | RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit |
YFR037C | 3.21 | 6.55E-4 | 0.04 | RSC8 | Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters |
YAR007C | 3.17 | 7.55E-4 | 0.06 | RFA1 | Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination |
YDR145W | 3.11 | 9.35E-4 | 0.31 | TAF12 | Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A |