Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YPR085C | 15.80 | 3.09E-56 | 5.78 | ASA1 | Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1 |
YHR062C | 12.40 | 1.63E-35 | 5.78 | RPP1 | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs |
YMR185W_p | 6.60 | 2.00E-11 | 2.35 | RTP1_p | Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene |
YNL112W | 4.26 | 1.03E-5 | 0.02 | DBP2 | ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites |
YOR262W | 4.24 | 1.12E-5 | 0.07 | GPN2 | Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B; required for establishment of sister chromatid cohesion |
YDR527W | 4.16 | 1.56E-5 | 0.33 | RBA50 | Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1 |
YOR210W | 3.84 | 6.18E-5 | 0.50 | RPB10 | RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III |
YGR195W | 3.34 | 4.23E-4 | 0.01 | SKI6 | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4) |
YLR005W | 3.33 | 4.42E-4 | 0.01 | SSL1 | Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p |
YEL019C | 3.31 | 4.62E-4 | 2.93E-4 | MMS21 | SUMO ligase and component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination |
YHR166C | 3.31 | 4.62E-4 | 0.11 | CDC23 | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition |
YIL046W | 3.20 | 6.76E-4 | 0.23 | MET30 | F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus |
YDR339C | 2.97 | 0.00147 | 0.15 | FCF1 | Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p |
YBL041W | 2.82 | 0.00240 | 0.00 | PRE7 | Beta 6 subunit of the 20S proteasome |
YFR027W | 2.82 | 0.00242 | 0.00 | ECO1 | Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress |