Deletion Strain | FD score | P-value | Gene | Gene Description |
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YDL020C | 53.80 | 0 | RPN4 | Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress |
YMR022W | 41.10 | 0 | UBC7 | Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly |
YGL119W | 30.30 | 2.03E-201 | COQ8 | Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication |
YNL111C | 26.10 | 1.33E-150 | CYB5 | Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation |
YDR204W | 24.00 | 2.28E-127 | COQ4 | Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex |
YML014W | 22.90 | 2.12E-116 | TRM9 | tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses |
YLR239C | 22.40 | 1.41E-111 | LIP2 | Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups |
YPR146C_d | 22.00 | 5.70E-108 | YPR146C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YOR125C | 20.30 | 6.54E-92 | CAT5 | Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation |
YER086W | 20.10 | 6.74E-90 | ILV1 | Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation |
YNR042W_d | 19.60 | 1.09E-85 | YNR042W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2 |
YER041W | 19.60 | 1.28E-85 | YEN1 | Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p |
YMR067C | 19.20 | 1.32E-82 | UBX4 | UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress |
YPL144W | 18.00 | 1.83E-72 | POC4 | Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions |
YFR007W | 17.30 | 1.05E-67 | YFH7 | Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases |