Deletion Strain | FD score | P-value | Gene | Gene Description |
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YBR069C | 7.51 | 2.85E-14 | TAT1 | Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress |
YLR415C_p | 6.45 | 5.68E-11 | YLR415C_p | Putative protein of unknown function; YLR415C is not an essential gene |
YGR223C | 5.73 | 5.12E-9 | HSV2 | Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization |
YAR035C-A_p | 5.57 | 1.28E-8 | YAR035C-A_p | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis |
YDL115C | 5.17 | 1.15E-7 | IWR1 | RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress |
YHR012W | 5.15 | 1.28E-7 | VPS29 | Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval |
YPL061W | 4.85 | 6.29E-7 | ALD6 | Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress |
YKL146W | 4.79 | 8.26E-7 | AVT3 | Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters |
YDR539W | 4.76 | 9.66E-7 | FDC1 | Putative phenylacrylic acid decarboxylase; essential for the decarboxylation of aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiD; GFP-fusion protein localizes to the cytoplasm |
YIR031C | 4.74 | 1.08E-6 | DAL7 | Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation |
YPL069C | 4.69 | 1.39E-6 | BTS1 | Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic |
YPL182C_d | 4.66 | 1.56E-6 | YPL182C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W |
YNL303W_d | 4.46 | 4.16E-6 | YNL303W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YIL012W_d | 4.38 | 5.88E-6 | YIL012W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YPL065W | 4.33 | 7.55E-6 | VPS28 | Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p |