4090-1979

[(Z,4Z)-4-[3-[(Z)-(3-ethyl-1,3-benzothiazol-2-ylidene)methyl]-5,5-dimethylcyclohex-2-en-1-ylidene]-2-methylbut-2-enylidene]-dimethylazanium

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_656
Screen concentration 187.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 22330961
SMILES CCN1C2=CC=CC=C2SC1=CC3=CC(=CC=C(C)C=[N+](C)C)CC(C3)(C)C
Standardized SMILES CCN1C(=CC2=CC(=CC=C(C)C=[N+](C)C)CC(C)(C)C2)Sc3ccccc13
Molecular weight 393.6079
ALogP 6.61
H-bond donor count 0
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.62
% growth inhibition (Hom. pool) 2.19


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 22330961
Download HIP data (tab-delimited text)  (excel)
Gene:DBP6(YNR038W)|FD-Score:3.55|P-value:1.91E-4|Clearance:0.2||SGD DESC:Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family Gene:DHR2(YKL078W)|FD-Score:3.17|P-value:7.61E-4|Clearance:0.16||SGD DESC:Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis Gene:ESP1(YGR098C)|FD-Score:-3.13|P-value:8.79E-4|Clearance:0||SGD DESC:Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress Gene:GCD10(YNL062C)|FD-Score:3.34|P-value:4.24E-4|Clearance:0.04||SGD DESC:Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression Gene:MCD4(YKL165C)|FD-Score:4.7|P-value:1.32E-6|Clearance:0.75||SGD DESC:Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes Gene:MSL5(YLR116W)|FD-Score:-3.6|P-value:1.56E-4|Clearance:0||SGD DESC:Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA Gene:RPP1(YHR062C)|FD-Score:3.36|P-value:3.95E-4|Clearance:0.02||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:TAF7(YMR227C)|FD-Score:3.3|P-value:4.92E-4|Clearance:0.12||SGD DESC:TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation Gene:UFE1(YOR075W)|FD-Score:4.3|P-value:8.48E-6|Clearance:0.75||SGD DESC:t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER Gene:YDL221W(YDL221W_d)|FD-Score:-3.24|P-value:5.88E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13 Gene:DBP6(YNR038W)|FD-Score:3.55|P-value:1.91E-4|Clearance:0.2||SGD DESC:Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family Gene:DHR2(YKL078W)|FD-Score:3.17|P-value:7.61E-4|Clearance:0.16||SGD DESC:Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis Gene:ESP1(YGR098C)|FD-Score:-3.13|P-value:8.79E-4|Clearance:0||SGD DESC:Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress Gene:GCD10(YNL062C)|FD-Score:3.34|P-value:4.24E-4|Clearance:0.04||SGD DESC:Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression Gene:MCD4(YKL165C)|FD-Score:4.7|P-value:1.32E-6|Clearance:0.75||SGD DESC:Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes Gene:MSL5(YLR116W)|FD-Score:-3.6|P-value:1.56E-4|Clearance:0||SGD DESC:Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA Gene:RPP1(YHR062C)|FD-Score:3.36|P-value:3.95E-4|Clearance:0.02||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:TAF7(YMR227C)|FD-Score:3.3|P-value:4.92E-4|Clearance:0.12||SGD DESC:TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation Gene:UFE1(YOR075W)|FD-Score:4.3|P-value:8.48E-6|Clearance:0.75||SGD DESC:t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER Gene:YDL221W(YDL221W_d)|FD-Score:-3.24|P-value:5.88E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 22330961
Download HOP data (tab-delimited text)  (excel)
Gene:AGX1(YFL030W)|FD-Score:3.95|P-value:3.98E-5||SGD DESC:Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases Gene:AIP1(YMR092C)|FD-Score:-3.29|P-value:4.95E-4||SGD DESC:Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress Gene:ATP10(YLR393W)|FD-Score:3.69|P-value:1.14E-4||SGD DESC:Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6 Gene:BCH1(YMR237W)|FD-Score:3.28|P-value:5.25E-4||SGD DESC:Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; BCH1 has a paralog, BUD7, that arose from the whole genome duplication Gene:BNS1(YGR230W)|FD-Score:-3.43|P-value:3.07E-4||SGD DESC:Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis Gene:BRP1(YGL007W_d)|FD-Score:3.5|P-value:2.30E-4||SGD DESC:Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 Gene:BUD32(YGR262C)|FD-Score:-3.55|P-value:1.92E-4||SGD DESC:Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription Gene:CGI121(YML036W)|FD-Score:3.64|P-value:1.34E-4||SGD DESC:Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification Gene:CSG2(YBR036C)|FD-Score:3.39|P-value:3.49E-4||SGD DESC:Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress Gene:CUE1(YMR264W)|FD-Score:3.51|P-value:2.21E-4||SGD DESC:Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication Gene:CUE3(YGL110C)|FD-Score:3.62|P-value:1.48E-4||SGD DESC:Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination Gene:EMC5(YIL027C)|FD-Score:8|P-value:6.05E-16||SGD DESC:Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT Gene:EPS1(YIL005W)|FD-Score:4.17|P-value:1.49E-5||SGD DESC:ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family Gene:FCY21(YER060W)|FD-Score:3.37|P-value:3.76E-4||SGD DESC:Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function Gene:FMO1(YHR176W)|FD-Score:-3.13|P-value:8.65E-4||SGD DESC:Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins Gene:GEA1(YJR031C)|FD-Score:3.12|P-value:9.14E-4||SGD DESC:Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication Gene:GLK1(YCL040W)|FD-Score:-3.3|P-value:4.87E-4||SGD DESC:Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication Gene:KIN1(YDR122W)|FD-Score:3.43|P-value:3.00E-4||SGD DESC:Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p Gene:LAS21(YJL062W)|FD-Score:3.09|P-value:9.95E-4||SGD DESC:Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity Gene:MGS1(YNL218W)|FD-Score:4.06|P-value:2.42E-5||SGD DESC:Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress Gene:MPD1(YOR288C)|FD-Score:3.69|P-value:1.12E-4||SGD DESC:Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation Gene:NDL1(YLR254C)|FD-Score:3.17|P-value:7.67E-4||SGD DESC:Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends Gene:NPY1(YGL067W)|FD-Score:3.16|P-value:7.91E-4||SGD DESC:NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member Gene:OAF3(YKR064W)|FD-Score:3.86|P-value:5.68E-5||SGD DESC:Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress Gene:ORM1(YGR038W)|FD-Score:4.19|P-value:1.40E-5||SGD DESC:Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control Gene:PEX29(YDR479C)|FD-Score:3.73|P-value:9.50E-5||SGD DESC:Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress Gene:PEX4(YGR133W)|FD-Score:-3.36|P-value:3.85E-4||SGD DESC:Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis Gene:PNC1(YGL037C)|FD-Score:3.14|P-value:8.42E-4||SGD DESC:Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress Gene:POX1(YGL205W)|FD-Score:3.34|P-value:4.20E-4||SGD DESC:Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix Gene:RBG1(YAL036C)|FD-Score:3.16|P-value:7.95E-4||SGD DESC:Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid Gene:RMD6(YEL072W)|FD-Score:3.45|P-value:2.81E-4||SGD DESC:Protein required for sporulation Gene:RPS11B(YBR048W)|FD-Score:5.11|P-value:1.65E-7||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication Gene:RTA1(YGR213C)|FD-Score:3.18|P-value:7.47E-4||SGD DESC:Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein Gene:SEC28(YIL076W)|FD-Score:-4.77|P-value:9.37E-7||SGD DESC:Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress Gene:SFC1(YJR095W)|FD-Score:3.16|P-value:7.81E-4||SGD DESC:Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization Gene:SKI2(YLR398C)|FD-Score:3.71|P-value:1.05E-4||SGD DESC:Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay Gene:SPH1(YLR313C)|FD-Score:3.58|P-value:1.74E-4||SGD DESC:Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p Gene:SPS4(YOR313C)|FD-Score:4.72|P-value:1.18E-6||SGD DESC:Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage Gene:SSA1(YAL005C)|FD-Score:4.27|P-value:9.66E-6||SGD DESC:ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils Gene:STB3(YDR169C)|FD-Score:4.06|P-value:2.45E-5||SGD DESC:Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress Gene:SUT2(YPR009W)|FD-Score:3.26|P-value:5.58E-4||SGD DESC:Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p Gene:THI7(YLR237W)|FD-Score:4.2|P-value:1.35E-5||SGD DESC:Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia Gene:UBP13(YBL067C)|FD-Score:3.44|P-value:2.88E-4||SGD DESC:Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication Gene:UBX6(YJL048C)|FD-Score:-3.11|P-value:9.31E-4||SGD DESC:UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication Gene:USV1(YPL230W)|FD-Score:4.24|P-value:1.12E-5||SGD DESC:Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication Gene:YBR259W(YBR259W_p)|FD-Score:-3.53|P-value:2.10E-4||SGD DESC:Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress Gene:YDL057W(YDL057W_p)|FD-Score:3.25|P-value:5.82E-4||SGD DESC:Putative protein of unknown function; YDL057W is not an essential gene Gene:YER084W(YER084W_p)|FD-Score:3.26|P-value:5.53E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YGR011W(YGR011W_d)|FD-Score:4.98|P-value:3.12E-7||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHM2(YMR241W)|FD-Score:3.09|P-value:9.85E-4||SGD DESC:Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome Gene:YHR202W(YHR202W_p)|FD-Score:3.33|P-value:4.34E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization Gene:YIL166C(YIL166C_p)|FD-Score:3.48|P-value:2.52E-4||SGD DESC:Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene Gene:YJL150W(YJL150W_d)|FD-Score:3.6|P-value:1.57E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YKL131W(YKL131W_d)|FD-Score:3.89|P-value:4.98E-5||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLL058W(YLL058W_p)|FD-Score:5.24|P-value:8.05E-8||SGD DESC:Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene Gene:YLR177W(YLR177W_p)|FD-Score:3.81|P-value:7.05E-5||SGD DESC:Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication Gene:YLR352W(YLR352W_p)|FD-Score:3.13|P-value:8.81E-4||SGD DESC:Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene Gene:YLR422W(YLR422W_p)|FD-Score:3.87|P-value:5.46E-5||SGD DESC:Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein Gene:YMR074C(YMR074C)|FD-Score:7.36|P-value:9.47E-14||SGD DESC:Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress Gene:YMR087W(YMR087W)|FD-Score:3.93|P-value:4.27E-5||SGD DESC:Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain Gene:YPL264C(YPL264C_p)|FD-Score:4.56|P-value:2.57E-6||SGD DESC:Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene Gene:YPR011C(YPR011C_p)|FD-Score:5.38|P-value:3.71E-8||SGD DESC:Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:ZRT1(YGL255W)|FD-Score:3.97|P-value:3.53E-5||SGD DESC:High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor Gene:ZTA1(YBR046C)|FD-Score:3.27|P-value:5.45E-4||SGD DESC:NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin Gene:AGX1(YFL030W)|FD-Score:3.95|P-value:3.98E-5||SGD DESC:Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases Gene:AIP1(YMR092C)|FD-Score:-3.29|P-value:4.95E-4||SGD DESC:Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress Gene:ATP10(YLR393W)|FD-Score:3.69|P-value:1.14E-4||SGD DESC:Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6 Gene:BCH1(YMR237W)|FD-Score:3.28|P-value:5.25E-4||SGD DESC:Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; BCH1 has a paralog, BUD7, that arose from the whole genome duplication Gene:BNS1(YGR230W)|FD-Score:-3.43|P-value:3.07E-4||SGD DESC:Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis Gene:BRP1(YGL007W_d)|FD-Score:3.5|P-value:2.30E-4||SGD DESC:Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 Gene:BUD32(YGR262C)|FD-Score:-3.55|P-value:1.92E-4||SGD DESC:Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription Gene:CGI121(YML036W)|FD-Score:3.64|P-value:1.34E-4||SGD DESC:Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification Gene:CSG2(YBR036C)|FD-Score:3.39|P-value:3.49E-4||SGD DESC:Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress Gene:CUE1(YMR264W)|FD-Score:3.51|P-value:2.21E-4||SGD DESC:Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication Gene:CUE3(YGL110C)|FD-Score:3.62|P-value:1.48E-4||SGD DESC:Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination Gene:EMC5(YIL027C)|FD-Score:8|P-value:6.05E-16||SGD DESC:Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT Gene:EPS1(YIL005W)|FD-Score:4.17|P-value:1.49E-5||SGD DESC:ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family Gene:FCY21(YER060W)|FD-Score:3.37|P-value:3.76E-4||SGD DESC:Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function Gene:FMO1(YHR176W)|FD-Score:-3.13|P-value:8.65E-4||SGD DESC:Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins Gene:GEA1(YJR031C)|FD-Score:3.12|P-value:9.14E-4||SGD DESC:Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication Gene:GLK1(YCL040W)|FD-Score:-3.3|P-value:4.87E-4||SGD DESC:Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication Gene:KIN1(YDR122W)|FD-Score:3.43|P-value:3.00E-4||SGD DESC:Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p Gene:LAS21(YJL062W)|FD-Score:3.09|P-value:9.95E-4||SGD DESC:Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity Gene:MGS1(YNL218W)|FD-Score:4.06|P-value:2.42E-5||SGD DESC:Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress Gene:MPD1(YOR288C)|FD-Score:3.69|P-value:1.12E-4||SGD DESC:Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation Gene:NDL1(YLR254C)|FD-Score:3.17|P-value:7.67E-4||SGD DESC:Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends Gene:NPY1(YGL067W)|FD-Score:3.16|P-value:7.91E-4||SGD DESC:NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member Gene:OAF3(YKR064W)|FD-Score:3.86|P-value:5.68E-5||SGD DESC:Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress Gene:ORM1(YGR038W)|FD-Score:4.19|P-value:1.40E-5||SGD DESC:Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control Gene:PEX29(YDR479C)|FD-Score:3.73|P-value:9.50E-5||SGD DESC:Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress Gene:PEX4(YGR133W)|FD-Score:-3.36|P-value:3.85E-4||SGD DESC:Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis Gene:PNC1(YGL037C)|FD-Score:3.14|P-value:8.42E-4||SGD DESC:Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress Gene:POX1(YGL205W)|FD-Score:3.34|P-value:4.20E-4||SGD DESC:Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix Gene:RBG1(YAL036C)|FD-Score:3.16|P-value:7.95E-4||SGD DESC:Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid Gene:RMD6(YEL072W)|FD-Score:3.45|P-value:2.81E-4||SGD DESC:Protein required for sporulation Gene:RPS11B(YBR048W)|FD-Score:5.11|P-value:1.65E-7||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication Gene:RTA1(YGR213C)|FD-Score:3.18|P-value:7.47E-4||SGD DESC:Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein Gene:SEC28(YIL076W)|FD-Score:-4.77|P-value:9.37E-7||SGD DESC:Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress Gene:SFC1(YJR095W)|FD-Score:3.16|P-value:7.81E-4||SGD DESC:Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization Gene:SKI2(YLR398C)|FD-Score:3.71|P-value:1.05E-4||SGD DESC:Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay Gene:SPH1(YLR313C)|FD-Score:3.58|P-value:1.74E-4||SGD DESC:Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p Gene:SPS4(YOR313C)|FD-Score:4.72|P-value:1.18E-6||SGD DESC:Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage Gene:SSA1(YAL005C)|FD-Score:4.27|P-value:9.66E-6||SGD DESC:ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils Gene:STB3(YDR169C)|FD-Score:4.06|P-value:2.45E-5||SGD DESC:Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress Gene:SUT2(YPR009W)|FD-Score:3.26|P-value:5.58E-4||SGD DESC:Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p Gene:THI7(YLR237W)|FD-Score:4.2|P-value:1.35E-5||SGD DESC:Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia Gene:UBP13(YBL067C)|FD-Score:3.44|P-value:2.88E-4||SGD DESC:Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication Gene:UBX6(YJL048C)|FD-Score:-3.11|P-value:9.31E-4||SGD DESC:UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication Gene:USV1(YPL230W)|FD-Score:4.24|P-value:1.12E-5||SGD DESC:Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication Gene:YBR259W(YBR259W_p)|FD-Score:-3.53|P-value:2.10E-4||SGD DESC:Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress Gene:YDL057W(YDL057W_p)|FD-Score:3.25|P-value:5.82E-4||SGD DESC:Putative protein of unknown function; YDL057W is not an essential gene Gene:YER084W(YER084W_p)|FD-Score:3.26|P-value:5.53E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YGR011W(YGR011W_d)|FD-Score:4.98|P-value:3.12E-7||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHM2(YMR241W)|FD-Score:3.09|P-value:9.85E-4||SGD DESC:Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome Gene:YHR202W(YHR202W_p)|FD-Score:3.33|P-value:4.34E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization Gene:YIL166C(YIL166C_p)|FD-Score:3.48|P-value:2.52E-4||SGD DESC:Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene Gene:YJL150W(YJL150W_d)|FD-Score:3.6|P-value:1.57E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YKL131W(YKL131W_d)|FD-Score:3.89|P-value:4.98E-5||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLL058W(YLL058W_p)|FD-Score:5.24|P-value:8.05E-8||SGD DESC:Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene Gene:YLR177W(YLR177W_p)|FD-Score:3.81|P-value:7.05E-5||SGD DESC:Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication Gene:YLR352W(YLR352W_p)|FD-Score:3.13|P-value:8.81E-4||SGD DESC:Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene Gene:YLR422W(YLR422W_p)|FD-Score:3.87|P-value:5.46E-5||SGD DESC:Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein Gene:YMR074C(YMR074C)|FD-Score:7.36|P-value:9.47E-14||SGD DESC:Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress Gene:YMR087W(YMR087W)|FD-Score:3.93|P-value:4.27E-5||SGD DESC:Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain Gene:YPL264C(YPL264C_p)|FD-Score:4.56|P-value:2.57E-6||SGD DESC:Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene Gene:YPR011C(YPR011C_p)|FD-Score:5.38|P-value:3.71E-8||SGD DESC:Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:ZRT1(YGL255W)|FD-Score:3.97|P-value:3.53E-5||SGD DESC:High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor Gene:ZTA1(YBR046C)|FD-Score:3.27|P-value:5.45E-4||SGD DESC:NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YKL165C4.701.32E-60.75MCD4Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
YOR075W4.308.48E-60.75UFE1t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER
YNR038W3.551.91E-40.20DBP6Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family
YHR062C3.363.95E-40.02RPP1Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YNL062C3.344.24E-40.04GCD10Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
YMR227C3.304.92E-40.12TAF7TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YKL078W3.177.61E-40.16DHR2Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis
YOR272W3.010.001300.00YTM1Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats
YGL233W3.010.001310.04SEC15Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase
YHR019C2.970.001500.05DED81Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
YPR110C2.920.001760.00RPC40RNA polymerase subunit AC40, common to RNA polymerase I and III
YPR019W2.920.001780.12MCM4Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p
YJR076C2.790.002600.03CDC11Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells
YMR211W2.760.002880.01DML1Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
YGR145W2.750.002990.02ENP2Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YIL027C8.006.05E-16EMC5Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT
YMR074C7.369.47E-14YMR074CProtein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress
YPR011C_p5.383.71E-8YPR011C_pPutative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLL058W_p5.248.05E-8YLL058W_pPutative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene
YBR048W5.111.65E-7RPS11BProtein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication
YGR011W_d4.983.12E-7YGR011W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR313C4.721.18E-6SPS4Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage
YPL264C_p4.562.57E-6YPL264C_pPutative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene
YAL005C4.279.66E-6SSA1ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils
YPL230W4.241.12E-5USV1Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication
YLR237W4.201.35E-5THI7Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
YGR038W4.191.40E-5ORM1Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control
YIL005W4.171.49E-5EPS1ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family
YNL218W4.062.42E-5MGS1Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
YDR169C4.062.45E-5STB3Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress

GO enrichment analysis for SGTC_656
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0732.05E-8SGTC_12550566-0045 221.0 μMChemDiv (Drug-like library)27884690.0714286excess fatty acid
0.0631.32E-6SGTC_7431275-0778 158.0 μMChemDiv (Drug-like library)28492570.0740741excess fatty acid
0.0542.94E-5SGTC_7950685-0265 78.0 μMChemDiv (Drug-like library)3027540.060241excess fatty acid
0.0543.57E-5SGTC_6671498-1044 59.0 μMChemDiv (Drug-like library)67399820.0823529RPP1 & pyrimidine depletion
0.0534.50E-5SGTC_1629st005085 44.9 μMTimTec (Natural product derivative library)242070910.0898876RPP1 & pyrimidine depletion
0.0501.05E-4SGTC_1127asiatic acid 681.4 nMTimTec (Natural product library)4706030.0754717
0.0491.51E-4SGTC_24775967686 25.2 μMMiscellaneous7761180.097561
0.0491.55E-4SGTC_32619137475 49.5 μMChembridge (Drug-like library)170276900.0526316RPP1 & pyrimidine depletion
0.0491.83E-4SGTC_13121218-2183 165.0 μMChemDiv (Drug-like library)67440730.0888889
0.0482.10E-4SGTC_32569138902 49.5 μMChembridge (Drug-like library)172287730.0823529PDR1
0.0455.38E-4SGTC_1100amiodarone 5.1 μMNIH Clinical Collection4413250.10101
0.0455.48E-4SGTC_6660272-0154 136.0 μMChemDiv (Drug-like library)68703120.102273cell wall
0.0447.70E-4SGTC_19215740136 50.0 μMMiscellaneous17742430.0744681TRP & mitochondrial translation
0.0430.00101SGTC_24335607874 27.8 μMMiscellaneous22524280.0967742
0.0420.00112SGTC_24984'-Methoxychalcone 54.6 μMMicrosource (Natural product library)6418180.133333RPP1 & pyrimidine depletion

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_396dithiazanine1.25 μM0.31645610578Miscellaneous518.476593.92904
SGTC_13101188-0297994 nM0.31251588352ChemDiv (Drug-like library)393.5887.47503azole & statin
SGTC_3832324-03957.37 μM0.2911393146421ChemDiv (Drug-like library)361.5237.25302azole & statin
SGTC_13712421-000832.7 μM0.2051282827552ChemDiv (Drug-like library)381.48956.35702mitochondrial processes
SGTC_5471120-0019610 nM0.1789473676939ChemDiv (Drug-like library)455.013667.96501azole & statin
SGTC_9021120-00022.07 μM0.1789473280475ChemDiv (Drug-like library)455.013667.96501azole & statin
SGTC_1230083-012066.68 μM0.17777816001701ChemDiv (Drug-like library)485.66187.49601
SGTC_22687933382153.85 μM0.164557935025Chembridge (Fragment library)263.381723.43814
SGTC_2646retinol96.75 μM0.158537445354Microsource (Natural product library)286.45165.31611
SGTC_3451362-0200395 μM0.1578951419823ChemDiv (Drug-like library)264.384684.45100