Deletion Strain | FD score | P-value | Gene | Gene Description |
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YOR323C | 19.90 | 5.14E-88 | PRO2 | Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis |
YDR010C_d | 17.10 | 5.37E-66 | YDR010C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YDR011W | 13.40 | 1.91E-41 | SNQ2 | Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species |
YDL226C | 10.20 | 5.92E-25 | GCS1 | ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p |
YHR004C | 9.17 | 2.48E-20 | NEM1 | Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard |
YGL168W | 8.58 | 4.62E-18 | HUR1 | Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene |
YDR435C | 6.82 | 4.48E-12 | PPM1 | Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits |
YIL154C | 6.65 | 1.43E-11 | IMP2' | Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat |
YAL009W | 6.41 | 7.27E-11 | SPO7 | Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation |
YDL041W_d | 6.16 | 3.68E-10 | YDL041W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C |
YDR184C | 6.01 | 9.51E-10 | ATC1 | Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress |
YOR246C | 5.97 | 1.21E-9 | ENV9 | Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts |
YDR389W | 5.83 | 2.75E-9 | SAC7 | GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate |
YGR184C | 5.41 | 3.16E-8 | UBR1 | E3 ubiquitin ligase (N-recognin); forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; plays a major role in targeting cytosolic misfolded proteins for degradation; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS) |
YHL027W | 5.36 | 4.11E-8 | RIM101 | Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC |