| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YDR225W | 6.08 | 6.04E-10 | HTA1 | Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p |
| YGR167W | 5.32 | 5.10E-8 | CLC1 | Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W |
| YKL043W | 5.17 | 1.16E-7 | PHD1 | Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication |
| YJL073W | 4.88 | 5.24E-7 | JEM1 | DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2 |
| YPR123C_d | 4.86 | 5.93E-7 | YPR123C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR |
| YDR004W | 4.84 | 6.37E-7 | RAD57 | Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p |
| YBL106C | 4.84 | 6.56E-7 | SRO77 | Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication |
| YGR230W | 4.72 | 1.17E-6 | BNS1 | Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis |
| YKL169C_d | 4.69 | 1.39E-6 | YKL169C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38 |
| YGR235C | 4.59 | 2.23E-6 | MOS2 | Mitochondrial inner membrane protein; non-essential component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture |
| YNR072W | 4.48 | 3.76E-6 | HXT17 | Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose |
| YOR191W | 4.32 | 7.69E-6 | ULS1 | Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress |
| YMR166C_p | 4.26 | 1.03E-5 | YMR166C_p | Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene |
| YBL039C | 4.24 | 1.10E-5 | URA7 | Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication |
| YMR209C_p | 4.16 | 1.62E-5 | YMR209C_p | Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene |
