1218-2179

6-[(2-methoxyanilino)methylidene]-2-nitrocyclohexa-2,4-dien-1-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_678
Screen concentration 85.9 μM
Source ChemDiv (Drug-like library)
PubChem CID 6820081
SMILES COC1=CC=CC=C1NC=C2C=CC=C(C2=O)[N+](=O)[O-]
Standardized SMILES COc1ccccc1N=Cc2cccc(c2O)[N+](=O)[O-]
Molecular weight 272.2561
ALogP 1.83
H-bond donor count 1
H-bond acceptor count 5
Response signature RNA pol III & RNase P/MRP

Pool Growth Kinetics
% growth inhibition (Het. pool) 14.75
% growth inhibition (Hom. pool) 6.4


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 6820081
Download HIP data (tab-delimited text)  (excel)
Gene:PRP42(YDR235W)|FD-Score:3.23|P-value:6.14E-4|Clearance:0.13||SGD DESC:U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats Gene:RPA43(YOR340C)|FD-Score:3.76|P-value:8.53E-5|Clearance:0.49||SGD DESC:RNA polymerase I subunit A43 Gene:RPO31(YOR116C)|FD-Score:11.3|P-value:9.62E-30|Clearance:7.51||SGD DESC:RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 Gene:RRP9(YPR137W)|FD-Score:3.27|P-value:5.45E-4|Clearance:0.03||SGD DESC:Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein Gene:SEC11(YIR022W)|FD-Score:3.1|P-value:9.70E-4|Clearance:0.21||SGD DESC:18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum Gene:PRP42(YDR235W)|FD-Score:3.23|P-value:6.14E-4|Clearance:0.13||SGD DESC:U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats Gene:RPA43(YOR340C)|FD-Score:3.76|P-value:8.53E-5|Clearance:0.49||SGD DESC:RNA polymerase I subunit A43 Gene:RPO31(YOR116C)|FD-Score:11.3|P-value:9.62E-30|Clearance:7.51||SGD DESC:RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 Gene:RRP9(YPR137W)|FD-Score:3.27|P-value:5.45E-4|Clearance:0.03||SGD DESC:Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein Gene:SEC11(YIR022W)|FD-Score:3.1|P-value:9.70E-4|Clearance:0.21||SGD DESC:18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 6820081
Download HOP data (tab-delimited text)  (excel)
Gene:ADR1(YDR216W)|FD-Score:3.12|P-value:8.99E-4||SGD DESC:Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization Gene:AGX1(YFL030W)|FD-Score:3.36|P-value:3.85E-4||SGD DESC:Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases Gene:CHA1(YCL064C)|FD-Score:4.17|P-value:1.51E-5||SGD DESC:Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine Gene:CMK2(YOL016C)|FD-Score:3.7|P-value:1.09E-4||SGD DESC:Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication Gene:COX5B(YIL111W)|FD-Score:-3.21|P-value:6.54E-4||SGD DESC:Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication Gene:HPA2(YPR193C)|FD-Score:4.06|P-value:2.44E-5||SGD DESC:Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity Gene:ISU1(YPL135W)|FD-Score:5.9|P-value:1.80E-9||SGD DESC:Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable Gene:JJJ3(YJR097W)|FD-Score:3.13|P-value:8.79E-4||SGD DESC:Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4 Gene:KXD1(YGL079W_p)|FD-Score:3.31|P-value:4.60E-4||SGD DESC:Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome Gene:MSN2(YMR037C)|FD-Score:-3.24|P-value:5.92E-4||SGD DESC:Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN2 has a paralog, MSN4, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:PUB1(YNL016W)|FD-Score:-3.43|P-value:3.03E-4||SGD DESC:Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress Gene:RGP1(YDR137W)|FD-Score:3.1|P-value:9.52E-4||SGD DESC:Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p Gene:TRM7(YBR061C)|FD-Score:5.32|P-value:5.24E-8||SGD DESC:2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively Gene:YBR013C(YBR013C_p)|FD-Score:3.59|P-value:1.65E-4||SGD DESC:Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein Gene:YDR102C(YDR102C_d)|FD-Score:-3.34|P-value:4.15E-4||SGD DESC:Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index Gene:YER187W(YER187W_p)|FD-Score:3.16|P-value:7.77E-4||SGD DESC:Putative protein of unknown function; induced in respiratory-deficient cells Gene:YFL032W(YFL032W_d)|FD-Score:4.16|P-value:1.56E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene Gene:YGL242C(YGL242C_p)|FD-Score:3.3|P-value:4.91E-4||SGD DESC:Putative protein of unknown function; deletion mutant is viable Gene:YHR138C(YHR138C_p)|FD-Score:3.67|P-value:1.23E-4||SGD DESC:Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress Gene:ADR1(YDR216W)|FD-Score:3.12|P-value:8.99E-4||SGD DESC:Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization Gene:AGX1(YFL030W)|FD-Score:3.36|P-value:3.85E-4||SGD DESC:Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases Gene:CHA1(YCL064C)|FD-Score:4.17|P-value:1.51E-5||SGD DESC:Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine Gene:CMK2(YOL016C)|FD-Score:3.7|P-value:1.09E-4||SGD DESC:Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication Gene:COX5B(YIL111W)|FD-Score:-3.21|P-value:6.54E-4||SGD DESC:Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication Gene:HPA2(YPR193C)|FD-Score:4.06|P-value:2.44E-5||SGD DESC:Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity Gene:ISU1(YPL135W)|FD-Score:5.9|P-value:1.80E-9||SGD DESC:Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable Gene:JJJ3(YJR097W)|FD-Score:3.13|P-value:8.79E-4||SGD DESC:Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4 Gene:KXD1(YGL079W_p)|FD-Score:3.31|P-value:4.60E-4||SGD DESC:Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome Gene:MSN2(YMR037C)|FD-Score:-3.24|P-value:5.92E-4||SGD DESC:Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN2 has a paralog, MSN4, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:PUB1(YNL016W)|FD-Score:-3.43|P-value:3.03E-4||SGD DESC:Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress Gene:RGP1(YDR137W)|FD-Score:3.1|P-value:9.52E-4||SGD DESC:Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p Gene:TRM7(YBR061C)|FD-Score:5.32|P-value:5.24E-8||SGD DESC:2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively Gene:YBR013C(YBR013C_p)|FD-Score:3.59|P-value:1.65E-4||SGD DESC:Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein Gene:YDR102C(YDR102C_d)|FD-Score:-3.34|P-value:4.15E-4||SGD DESC:Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index Gene:YER187W(YER187W_p)|FD-Score:3.16|P-value:7.77E-4||SGD DESC:Putative protein of unknown function; induced in respiratory-deficient cells Gene:YFL032W(YFL032W_d)|FD-Score:4.16|P-value:1.56E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene Gene:YGL242C(YGL242C_p)|FD-Score:3.3|P-value:4.91E-4||SGD DESC:Putative protein of unknown function; deletion mutant is viable Gene:YHR138C(YHR138C_p)|FD-Score:3.67|P-value:1.23E-4||SGD DESC:Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YOR116C11.309.62E-307.51RPO31RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
YOR340C3.768.53E-50.49RPA43RNA polymerase I subunit A43
YPR137W3.275.45E-40.03RRP9Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
YDR235W3.236.14E-40.13PRP42U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
YIR022W3.109.70E-40.21SEC1118kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum
YBR247C2.880.001960.17ENP1Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus
YOR224C2.710.003350.01RPB8RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III
YDR324C2.700.003420.03UTP4Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript
YKR025W2.680.003700.14RPC37RNA polymerase III subunit C37
YLR186W2.540.005482.19E-4EMG1Methyltransferase for rRNA; catalyzes methylation of the pseudouridine residue 1191 of 18S rRNA; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independently of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and the equivalent mutation in yeast affects Emg1p dimerization and localization but not its methyltransferase activity
YLR105C2.540.005490.09SEN2Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease
YDL105W2.450.007060.02NSE4Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
YAL033W2.430.007450.01POP5Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YOR278W2.430.007600.05HEM4Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria
YDL152W_d2.380.008600.01YDL152W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YPL135W5.901.80E-9ISU1Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YBR061C5.325.24E-8TRM72'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively
YCL064C4.171.51E-5CHA1Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
YFL032W_d4.161.56E-5YFL032W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
YPR193C4.062.44E-5HPA2Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity
YOL016C3.701.09E-4CMK2Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
YHR138C_p3.671.23E-4YHR138C_pProtein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress
YBR013C_p3.591.65E-4YBR013C_pPutative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein
YFL030W3.363.85E-4AGX1Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YGL079W_p3.314.60E-4KXD1_pPutative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome
YGL242C_p3.304.91E-4YGL242C_pPutative protein of unknown function; deletion mutant is viable
YER187W_p3.167.77E-4YER187W_pPutative protein of unknown function; induced in respiratory-deficient cells
YJR097W3.138.79E-4JJJ3Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4
YDR216W3.128.99E-4ADR1Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YDR137W3.109.52E-4RGP1Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p

GO enrichment analysis for SGTC_678
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.3381.68E-157SGTC_1930st074634 34.3 μMTimTec (Natural product derivative library)6842530.106061RNA pol III & RNase P/MRP
0.3031.03E-125SGTC_2544sphondin 68.5 μMMicrosource (Natural product library)1081040.153846RNA pol III & RNase P/MRP
0.2971.60E-120SGTC_2738aclarubicin 5.5 μMMiscellaneous4514150.10084RNA pol III & RNase P/MRP
0.2346.07E-74SGTC_1522st012842 45.6 μMTimTec (Pure natural product library)34910670.11236RNA pol III & RNase P/MRP
0.2081.39E-58SGTC_712r015-0009 80.6 μMChemDiv (Drug-like library)68138720.42
0.2066.53E-58SGTC_2612dictamnine 15.5 μMMicrosource (Natural product library)680850.147541RNA pol III & RNase P/MRP
0.2037.22E-56SGTC_32479135149 49.5 μMChembridge (Drug-like library)89344360.0833333DNA damage response
0.2022.80E-55SGTC_2522biochanin a 4.9 μMMicrosource (Natural product library)52803730.147059RNA pol III & RNase P/MRP
0.1977.39E-53SGTC_1915st067105 30.6 μMTimTec (Natural product derivative library)697510.132075RNA pol III & RNase P/MRP
0.1653.09E-37SGTC_659k018-0002 107.0 μMChemDiv (Drug-like library)67978790.376812
0.1625.48E-36SGTC_597k018-0003 82.8 μMChemDiv (Drug-like library)67862340.352113RNA pol III & RNase P/MRP
0.1505.52E-31SGTC_2411st077133 39.9 μMTimTec (Natural product derivative library)14031420.121622RNA pol III & RNase P/MRP
0.1461.73E-29SGTC_2671danthron 100.0 μMMicrosource (Natural product library)29500.153846DNA damage response
0.1375.23E-26SGTC_8291635-0120 117.0 μMChemDiv (Drug-like library)2850540.0806452DNA damage response
0.1361.00E-25SGTC_15258-methoxypsoralen 92.5 μMTimTec (Pure natural product library)41140.119403DNA damage response

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_13121218-2183165 μM0.5090916744073ChemDiv (Drug-like library)299.281420.96225
SGTC_322k048-013619.3 μM0.4655176823282ChemDiv (Drug-like library)430.04822.88215RSC & ERG11
SGTC_608k048-0125159 μM0.4482766817652ChemDiv (Drug-like library)350.164082.16525
SGTC_23955646831180.19 μM0.4477616808628Miscellaneous401.414664.7516
SGTC_10258-009857.37 μM0.4310346790032ChemDiv (Drug-like library)317.253641.71917heme biosynthesis & mitochondrial translocase
SGTC_712r015-000980.6 μM0.426813872ChemDiv (Drug-like library)342.38898-0.25426
SGTC_9771348-1378135 μM0.40625X977ChemDiv (Drug-like library)362.342162.83982
SGTC_659k018-0002107 μM0.3768126797879ChemDiv (Drug-like library)392.387981.97217
SGTC_1763st04448294.5 μM0.36734788505TimTec (Natural product derivative library)211.171461.45105copper-dependent oxidative stress
SGTC_5571315-011016.2 μM0.3620696833801ChemDiv (Drug-like library)509.077562.63114Golgi