| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YPL135W | 5.90 | 1.80E-9 | ISU1 | Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable |
| YBR061C | 5.32 | 5.24E-8 | TRM7 | 2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively |
| YCL064C | 4.17 | 1.51E-5 | CHA1 | Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine |
| YFL032W_d | 4.16 | 1.56E-5 | YFL032W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene |
| YPR193C | 4.06 | 2.44E-5 | HPA2 | Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity |
| YOL016C | 3.70 | 1.09E-4 | CMK2 | Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication |
| YHR138C_p | 3.67 | 1.23E-4 | YHR138C_p | Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress |
| YBR013C_p | 3.59 | 1.65E-4 | YBR013C_p | Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein |
| YFL030W | 3.36 | 3.85E-4 | AGX1 | Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases |
| YGL079W_p | 3.31 | 4.60E-4 | KXD1_p | Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome |
| YGL242C_p | 3.30 | 4.91E-4 | YGL242C_p | Putative protein of unknown function; deletion mutant is viable |
| YER187W_p | 3.16 | 7.77E-4 | YER187W_p | Putative protein of unknown function; induced in respiratory-deficient cells |
| YJR097W | 3.13 | 8.79E-4 | JJJ3 | Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4 |
| YDR216W | 3.12 | 8.99E-4 | ADR1 | Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization |
| YDR137W | 3.10 | 9.52E-4 | RGP1 | Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p |
