1642-0006

[3-(4-methylphenyl)-2,4-dioxo-1,3-thiazolidin-5-yl] N,N'-bis(4-methylphenyl)carbamimidothioate

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_681
Screen concentration 26.6 μM
Source ChemDiv (Drug-like library)
PubChem CID 4446530
SMILES CC1=CC=C(C=C1)NC(=NC2=CC=C(C=C2)C)SC3C(=O)N(C(=O)S3)C4=CC=C(C=C4)C
Standardized SMILES Cc1ccc(NC(=Nc2ccc(C)cc2)SC3SC(=O)N(C3=O)c4ccc(C)cc4)cc1
Molecular weight 461.599
ALogP 7.51
H-bond donor count 1
H-bond acceptor count 5
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 7.17
% growth inhibition (Hom. pool) 4.36


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 4446530
Download HIP data (tab-delimited text)  (excel)
Gene:ERG12(YMR208W)|FD-Score:3.29|P-value:5.01E-4|Clearance:0.13||SGD DESC:Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate Gene:HEM4(YOR278W)|FD-Score:3.1|P-value:9.62E-4|Clearance:0||SGD DESC:Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria Gene:NOP2(YNL061W)|FD-Score:3.13|P-value:8.82E-4|Clearance:0.03||SGD DESC:Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles Gene:NUP49(YGL172W)|FD-Score:3.1|P-value:9.66E-4|Clearance:0.05||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p) Gene:RFA1(YAR007C)|FD-Score:-3.58|P-value:1.71E-4|Clearance:0||SGD DESC:Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination Gene:RRP4(YHR069C)|FD-Score:3.5|P-value:2.32E-4|Clearance:0.19||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2) Gene:SPB1(YCL054W)|FD-Score:3.16|P-value:7.81E-4|Clearance:0.04||SGD DESC:AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants Gene:USO1(YDL058W)|FD-Score:3.31|P-value:4.67E-4|Clearance:0.02||SGD DESC:Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex Gene:ERG12(YMR208W)|FD-Score:3.29|P-value:5.01E-4|Clearance:0.13||SGD DESC:Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate Gene:HEM4(YOR278W)|FD-Score:3.1|P-value:9.62E-4|Clearance:0||SGD DESC:Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria Gene:NOP2(YNL061W)|FD-Score:3.13|P-value:8.82E-4|Clearance:0.03||SGD DESC:Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles Gene:NUP49(YGL172W)|FD-Score:3.1|P-value:9.66E-4|Clearance:0.05||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p) Gene:RFA1(YAR007C)|FD-Score:-3.58|P-value:1.71E-4|Clearance:0||SGD DESC:Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination Gene:RRP4(YHR069C)|FD-Score:3.5|P-value:2.32E-4|Clearance:0.19||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2) Gene:SPB1(YCL054W)|FD-Score:3.16|P-value:7.81E-4|Clearance:0.04||SGD DESC:AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants Gene:USO1(YDL058W)|FD-Score:3.31|P-value:4.67E-4|Clearance:0.02||SGD DESC:Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 4446530
Download HOP data (tab-delimited text)  (excel)
Gene:BLM10(YFL007W)|FD-Score:3.25|P-value:5.75E-4||SGD DESC:Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200 Gene:BZZ1(YHR114W)|FD-Score:-4.49|P-value:3.52E-6||SGD DESC:SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins Gene:EAF3(YPR023C)|FD-Score:-3.29|P-value:5.08E-4||SGD DESC:Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition Gene:ICY1(YMR195W)|FD-Score:-3.24|P-value:5.96E-4||SGD DESC:Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation Gene:LYP1(YNL268W)|FD-Score:3.25|P-value:5.74E-4||SGD DESC:Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids Gene:MIC23(YBL107C_p)|FD-Score:-3.26|P-value:5.50E-4||SGD DESC:Mitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C) Gene:MID2(YLR332W)|FD-Score:3.36|P-value:3.95E-4||SGD DESC:O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p Gene:PKH3(YDR466W)|FD-Score:4.51|P-value:3.27E-6||SGD DESC:Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant Gene:PRS4(YBL068W)|FD-Score:-3.23|P-value:6.15E-4||SGD DESC:5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication Gene:RML2(YEL050C)|FD-Score:3.3|P-value:4.81E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor Gene:RPL6A(YML073C)|FD-Score:3.14|P-value:8.49E-4||SGD DESC:Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication Gene:RPS8A(YBL072C)|FD-Score:3.85|P-value:5.96E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication Gene:SCW4(YGR279C)|FD-Score:3.39|P-value:3.46E-4||SGD DESC:Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating Gene:SHR5(YOL110W)|FD-Score:4|P-value:3.15E-5||SGD DESC:Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization Gene:YBR284W(YBR284W_p)|FD-Score:3.25|P-value:5.68E-4||SGD DESC:Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication Gene:YIG1(YPL201C)|FD-Score:3.84|P-value:6.21E-5||SGD DESC:Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol Gene:YLR036C(YLR036C_p)|FD-Score:-3.2|P-value:6.95E-4||SGD DESC:Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein Gene:YLR171W(YLR171W_d)|FD-Score:4.13|P-value:1.78E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPR050C(YPR050C_d)|FD-Score:4.3|P-value:8.65E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W Gene:BLM10(YFL007W)|FD-Score:3.25|P-value:5.75E-4||SGD DESC:Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200 Gene:BZZ1(YHR114W)|FD-Score:-4.49|P-value:3.52E-6||SGD DESC:SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins Gene:EAF3(YPR023C)|FD-Score:-3.29|P-value:5.08E-4||SGD DESC:Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition Gene:ICY1(YMR195W)|FD-Score:-3.24|P-value:5.96E-4||SGD DESC:Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation Gene:LYP1(YNL268W)|FD-Score:3.25|P-value:5.74E-4||SGD DESC:Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids Gene:MIC23(YBL107C_p)|FD-Score:-3.26|P-value:5.50E-4||SGD DESC:Mitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C) Gene:MID2(YLR332W)|FD-Score:3.36|P-value:3.95E-4||SGD DESC:O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p Gene:PKH3(YDR466W)|FD-Score:4.51|P-value:3.27E-6||SGD DESC:Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant Gene:PRS4(YBL068W)|FD-Score:-3.23|P-value:6.15E-4||SGD DESC:5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication Gene:RML2(YEL050C)|FD-Score:3.3|P-value:4.81E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor Gene:RPL6A(YML073C)|FD-Score:3.14|P-value:8.49E-4||SGD DESC:Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication Gene:RPS8A(YBL072C)|FD-Score:3.85|P-value:5.96E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication Gene:SCW4(YGR279C)|FD-Score:3.39|P-value:3.46E-4||SGD DESC:Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating Gene:SHR5(YOL110W)|FD-Score:4|P-value:3.15E-5||SGD DESC:Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization Gene:YBR284W(YBR284W_p)|FD-Score:3.25|P-value:5.68E-4||SGD DESC:Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication Gene:YIG1(YPL201C)|FD-Score:3.84|P-value:6.21E-5||SGD DESC:Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol Gene:YLR036C(YLR036C_p)|FD-Score:-3.2|P-value:6.95E-4||SGD DESC:Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein Gene:YLR171W(YLR171W_d)|FD-Score:4.13|P-value:1.78E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPR050C(YPR050C_d)|FD-Score:4.3|P-value:8.65E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YHR069C3.502.32E-40.19RRP4Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)
YDL058W3.314.67E-40.02USO1Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
YMR208W3.295.01E-40.13ERG12Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
YCL054W3.167.81E-40.04SPB1AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YNL061W3.138.82E-40.03NOP2Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
YOR278W3.109.62E-40.00HEM4Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria
YGL172W3.109.66E-40.05NUP49FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p)
YKL125W3.050.001150.07RRN3Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo
YKL042W2.980.001440.14SPC42Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane
YJL194W2.840.002260.02CDC6Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress
YFL039C2.820.002430.08ACT1Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
YDR240C2.730.003130.04SNU56Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex
YML093W2.690.003570.01UTP14Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
YDR394W2.680.003670.03RPT3One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B
YNL317W2.650.004060.06PFS2Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDR466W4.513.27E-6PKH3Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
YPR050C_d4.308.65E-6YPR050C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W
YLR171W_d4.131.78E-5YLR171W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL110W4.003.15E-5SHR5Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization
YBL072C3.855.96E-5RPS8AProtein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication
YPL201C3.846.21E-5YIG1Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol
YGR279C3.393.46E-4SCW4Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
YLR332W3.363.95E-4MID2O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
YEL050C3.304.81E-4RML2Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
YBR284W_p3.255.68E-4YBR284W_pPutative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication
YNL268W3.255.74E-4LYP1Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
YFL007W3.255.75E-4BLM10Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200
YML073C3.148.49E-4RPL6ARibosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication
YOR107W3.080.00104RGS2Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p
YNL325C3.010.00129FIG4Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain

GO enrichment analysis for SGTC_681
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1101.73E-17SGTC_6330437-0093 97.7 μMChemDiv (Drug-like library)28311180.0851064DNA intercalators
0.0881.30E-11SGTC_1459k035-0031 35.7 μMChemDiv (Drug-like library)38771280.0606061DNA intercalators
0.0864.85E-11SGTC_30409091894 49.5 μMChembridge (Drug-like library)252369660.0875DNA intercalators
0.0809.17E-10SGTC_412gemfibrozil 100.0 μMMiscellaneous34630.126761DNA intercalators
0.0782.34E-9SGTC_4711-acyl-paf 4.0 μMICCB bioactive library167593670.0340909DNA intercalators
0.0772.96E-9SGTC_12900986-0249 10.2 μMChemDiv (Drug-like library)533290.0724638DNA intercalators
0.0773.17E-9SGTC_1992st073643 23.3 μMTimTec (Natural product derivative library)31612920.0609756mitochondrial processes
0.0764.98E-9SGTC_1465k213-0056 144.0 μMChemDiv (Drug-like library)240488570.157895DNA intercalators
0.0741.37E-8SGTC_1250133-0007 11.8 μMChemDiv (Drug-like library)265410.0517241DNA intercalators
0.0732.42E-8SGTC_20725231554 129.0 μMChembridge (Fragment library)7895450.0666667
0.0723.04E-8SGTC_14984478-3555 97.6 μMChemDiv (Drug-like library)34379190.103896
0.0699.02E-8SGTC_170960-0276 49.8 μMChemDiv (Drug-like library)68211140.0729167
0.0691.26E-7SGTC_30059076496 71.4 μMChembridge (Drug-like library)213684100.208955
0.0681.82E-7SGTC_30369090181 49.5 μMChembridge (Drug-like library)252365860.108108
0.0656.97E-7SGTC_31989112019 49.5 μMChembridge (Drug-like library)455955550.075mitochondrial processes

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_23236148992148.28 μM0.3114752888220Chembridge (Fragment library)264.300281.55124
SGTC_13021159-0335255 μM0.28125649284ChemDiv (Drug-like library)314.358963.68715
SGTC_2469565501990.81 μM0.2794122788239Miscellaneous341.3813.18315
SGTC_2474532157043.32 μM0.2741942841384Miscellaneous297.37153.55303
SGTC_5891227-007034.1 μM0.2741942841384ChemDiv (Drug-like library)297.37153.55303
SGTC_8211114-026629.2 μM0.2741943123235ChemDiv (Drug-like library)363.229044.45214
SGTC_29087930301100 μM0.2727272223178Chembridge (Drug-like library)387.431143.00533
SGTC_7353076-0345636 μM0.2686572888990ChemDiv (Drug-like library)314.421943.39513
SGTC_10074101-003170 μM0.2575761146276ChemDiv (Drug-like library)424.4249431.55525
SGTC_4283448-415316.5 μM0.256413834874ChemDiv (Drug-like library)446.903962.99616TSC3-RPN4