Deletion Strain | FD score | P-value | Gene | Gene Description |
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YDL020C | 8.55 | 6.14E-18 | RPN4 | Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress |
YCR034W | 8.33 | 4.03E-17 | FEN1 | Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication |
YDL026W_d | 8.22 | 1.04E-16 | YDL026W_d | Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data |
YPL213W | 7.71 | 6.47E-15 | LEA1 | Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein |
YBL071C_d | 7.43 | 5.34E-14 | YBL071C_d | Dubious open reading frame, predicted protein contains a peroxisomal targeting signal |
YGL063W | 7.05 | 9.04E-13 | PUS2 | Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification |
YPL080C_d | 6.72 | 9.11E-12 | YPL080C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YDL130W | 6.42 | 6.93E-11 | RPP1B | Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component |
YLR006C | 6.13 | 4.26E-10 | SSK1 | Cytoplasmic response regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate |
YNL334C | 5.83 | 2.72E-9 | SNO2 | Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin |
YJL217W | 5.61 | 9.95E-9 | REE1 | Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle |
YIL009C-A | 5.53 | 1.59E-8 | EST3 | Component of the telomerase holoenzyme, involved in telomere replication |
YBR046C | 5.35 | 4.38E-8 | ZTA1 | NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin |
YKL124W | 5.20 | 1.01E-7 | SSH4 | Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases |
YML001W | 5.18 | 1.09E-7 | YPT7 | Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7 |