| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YBL104C | 6.46 | 5.35E-11 | SEA4 | Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites |
| YDR455C_d | 6.40 | 7.63E-11 | YDR455C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W |
| YHR181W | 5.37 | 3.87E-8 | SVP26 | Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment |
| YNR002C | 4.65 | 1.65E-6 | ATO2 | Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication |
| YNR064C | 4.25 | 1.09E-5 | YNR064C | Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides |
| YCR034W | 4.16 | 1.62E-5 | FEN1 | Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication |
| YHR137W | 4.00 | 3.20E-5 | ARO9 | Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism |
| YHR209W | 3.92 | 4.42E-5 | CRG1 | S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin |
| YHR158C | 3.87 | 5.54E-5 | KEL1 | Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate |
| YJL215C_d | 3.83 | 6.36E-5 | YJL215C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| YPR005C | 3.73 | 9.64E-5 | HAL1 | Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p |
| YLR308W | 3.71 | 1.03E-4 | CDA2 | Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall |
| YPR095C | 3.70 | 1.08E-4 | SYT1 | Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain |
| YIL016W | 3.64 | 1.36E-4 | SNL1 | Ribosome-associated protein proposed to act in protein synthesis and nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein |
| YMR011W | 3.64 | 1.36E-4 | HXT2 | High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose |
