4161-2696

4-[[2-[(E)-prop-1-enyl]phenoxy]methyl]benzoic acid

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_693
Screen concentration 114.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 805759
SMILES CC=CC1=CC=CC=C1OCC2=CC=C(C=C2)C(=O)O
Standardized SMILES CC=Cc1ccccc1OCc2ccc(cc2)C(=O)O
Molecular weight 268.3071
ALogP 3.98
H-bond donor count 1
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 9.57
% growth inhibition (Hom. pool) 8.49


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 805759
Download HIP data (tab-delimited text)  (excel)
Gene:CDC13(YDL220C)|FD-Score:3.77|P-value:8.25E-5|Clearance:0.21||SGD DESC:Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping; autophagy and proteasome are involved in Cdc13p degradation Gene:GCD2(YGR083C)|FD-Score:3.37|P-value:3.79E-4|Clearance:0.16||SGD DESC:Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression Gene:GPI13(YLL031C)|FD-Score:-5.16|P-value:1.24E-7|Clearance:0||SGD DESC:ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein Gene:MEC1(YBR136W)|FD-Score:3.79|P-value:7.41E-5|Clearance:0.03||SGD DESC:Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres Gene:MES1(YGR264C)|FD-Score:4.03|P-value:2.76E-5|Clearance:0.13||SGD DESC:Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs Gene:RIX1(YHR197W)|FD-Score:4.57|P-value:2.42E-6|Clearance:0.3||SGD DESC:Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; RIX1 is an essential gene Gene:RPC19(YNL113W)|FD-Score:3.55|P-value:1.89E-4|Clearance:0.19||SGD DESC:RNA polymerase subunit AC19, common to RNA polymerases I and III Gene:SCC4(YER147C)|FD-Score:3.2|P-value:6.80E-4|Clearance:0.13||SGD DESC:Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX Gene:SWI1(YPL016W)|FD-Score:4.27|P-value:9.62E-6|Clearance:0.24||SGD DESC:Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer Gene:UBC9(YDL064W)|FD-Score:3.9|P-value:4.82E-5|Clearance:0.11||SGD DESC:SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC) Gene:CDC13(YDL220C)|FD-Score:3.77|P-value:8.25E-5|Clearance:0.21||SGD DESC:Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping; autophagy and proteasome are involved in Cdc13p degradation Gene:GCD2(YGR083C)|FD-Score:3.37|P-value:3.79E-4|Clearance:0.16||SGD DESC:Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression Gene:GPI13(YLL031C)|FD-Score:-5.16|P-value:1.24E-7|Clearance:0||SGD DESC:ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein Gene:MEC1(YBR136W)|FD-Score:3.79|P-value:7.41E-5|Clearance:0.03||SGD DESC:Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres Gene:MES1(YGR264C)|FD-Score:4.03|P-value:2.76E-5|Clearance:0.13||SGD DESC:Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs Gene:RIX1(YHR197W)|FD-Score:4.57|P-value:2.42E-6|Clearance:0.3||SGD DESC:Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; RIX1 is an essential gene Gene:RPC19(YNL113W)|FD-Score:3.55|P-value:1.89E-4|Clearance:0.19||SGD DESC:RNA polymerase subunit AC19, common to RNA polymerases I and III Gene:SCC4(YER147C)|FD-Score:3.2|P-value:6.80E-4|Clearance:0.13||SGD DESC:Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX Gene:SWI1(YPL016W)|FD-Score:4.27|P-value:9.62E-6|Clearance:0.24||SGD DESC:Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer Gene:UBC9(YDL064W)|FD-Score:3.9|P-value:4.82E-5|Clearance:0.11||SGD DESC:SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 805759
Download HOP data (tab-delimited text)  (excel)
Gene:ARF1(YDL192W)|FD-Score:3.62|P-value:1.48E-4||SGD DESC:ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication Gene:ATG7(YHR171W)|FD-Score:-3.56|P-value:1.88E-4||SGD DESC:Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation Gene:BCK2(YER167W)|FD-Score:3.48|P-value:2.50E-4||SGD DESC:Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations Gene:BIO3(YNR058W)|FD-Score:4.01|P-value:2.98E-5||SGD DESC:7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis Gene:BRP1(YGL007W_d)|FD-Score:3.95|P-value:3.97E-5||SGD DESC:Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 Gene:FAR7(YFR008W)|FD-Score:3.5|P-value:2.32E-4||SGD DESC:Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress Gene:GUP1(YGL084C)|FD-Score:3.47|P-value:2.63E-4||SGD DESC:Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport Gene:IES2(YNL215W)|FD-Score:3.1|P-value:9.54E-4||SGD DESC:Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress Gene:IRC10(YOL015W)|FD-Score:4.13|P-value:1.84E-5||SGD DESC:Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci Gene:MHT1(YLL062C)|FD-Score:4.37|P-value:6.13E-6||SGD DESC:S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio Gene:MPH1(YIR002C)|FD-Score:-3.5|P-value:2.35E-4||SGD DESC:3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases Gene:MRPS28(YDR337W)|FD-Score:-3.31|P-value:4.68E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSC3(YLR219W)|FD-Score:3.54|P-value:1.97E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress Gene:PML39(YML107C)|FD-Score:3.67|P-value:1.23E-4||SGD DESC:Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes Gene:PRM10(YJL108C)|FD-Score:4.59|P-value:2.26E-6||SGD DESC:Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation Gene:PRM7(YDL039C)|FD-Score:3.13|P-value:8.65E-4||SGD DESC:Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements Gene:RTC5(YOR118W)|FD-Score:3.36|P-value:3.87E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity Gene:SNO2(YNL334C)|FD-Score:3.93|P-value:4.28E-5||SGD DESC:Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin Gene:SSU1(YPL092W)|FD-Score:3.34|P-value:4.25E-4||SGD DESC:Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein Gene:TOM6(YOR045W)|FD-Score:3.84|P-value:6.26E-5||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex Gene:URA8(YJR103W)|FD-Score:3.56|P-value:1.88E-4||SGD DESC:Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication Gene:YBL010C(YBL010C_p)|FD-Score:3.16|P-value:7.80E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles Gene:YCK1(YHR135C)|FD-Score:-4.18|P-value:1.45E-5||SGD DESC:Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; YCK1 has a paralog, YCK2, that arose from the whole genome duplication Gene:YCL074W(YCL074W)|FD-Score:4.23|P-value:1.14E-5||SGD DESC:Pseudogene: encodes fragment of Ty Pol protein Gene:YFL054C(YFL054C_p)|FD-Score:3.62|P-value:1.47E-4||SGD DESC:Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol Gene:YIH1(YCR059C)|FD-Score:5.65|P-value:8.21E-9||SGD DESC:Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT Gene:YIL029C(YIL029C_p)|FD-Score:5.35|P-value:4.41E-8||SGD DESC:Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W Gene:YLR217W(YLR217W_d)|FD-Score:4.05|P-value:2.53E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6 Gene:YOL085C(YOL085C_d)|FD-Score:4.17|P-value:1.50E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A Gene:YPR1(YDR368W)|FD-Score:3.37|P-value:3.81E-4||SGD DESC:NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication Gene:ARF1(YDL192W)|FD-Score:3.62|P-value:1.48E-4||SGD DESC:ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication Gene:ATG7(YHR171W)|FD-Score:-3.56|P-value:1.88E-4||SGD DESC:Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation Gene:BCK2(YER167W)|FD-Score:3.48|P-value:2.50E-4||SGD DESC:Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations Gene:BIO3(YNR058W)|FD-Score:4.01|P-value:2.98E-5||SGD DESC:7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis Gene:BRP1(YGL007W_d)|FD-Score:3.95|P-value:3.97E-5||SGD DESC:Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 Gene:FAR7(YFR008W)|FD-Score:3.5|P-value:2.32E-4||SGD DESC:Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress Gene:GUP1(YGL084C)|FD-Score:3.47|P-value:2.63E-4||SGD DESC:Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport Gene:IES2(YNL215W)|FD-Score:3.1|P-value:9.54E-4||SGD DESC:Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress Gene:IRC10(YOL015W)|FD-Score:4.13|P-value:1.84E-5||SGD DESC:Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci Gene:MHT1(YLL062C)|FD-Score:4.37|P-value:6.13E-6||SGD DESC:S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio Gene:MPH1(YIR002C)|FD-Score:-3.5|P-value:2.35E-4||SGD DESC:3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases Gene:MRPS28(YDR337W)|FD-Score:-3.31|P-value:4.68E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSC3(YLR219W)|FD-Score:3.54|P-value:1.97E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress Gene:PML39(YML107C)|FD-Score:3.67|P-value:1.23E-4||SGD DESC:Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes Gene:PRM10(YJL108C)|FD-Score:4.59|P-value:2.26E-6||SGD DESC:Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation Gene:PRM7(YDL039C)|FD-Score:3.13|P-value:8.65E-4||SGD DESC:Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements Gene:RTC5(YOR118W)|FD-Score:3.36|P-value:3.87E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity Gene:SNO2(YNL334C)|FD-Score:3.93|P-value:4.28E-5||SGD DESC:Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin Gene:SSU1(YPL092W)|FD-Score:3.34|P-value:4.25E-4||SGD DESC:Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein Gene:TOM6(YOR045W)|FD-Score:3.84|P-value:6.26E-5||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex Gene:URA8(YJR103W)|FD-Score:3.56|P-value:1.88E-4||SGD DESC:Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication Gene:YBL010C(YBL010C_p)|FD-Score:3.16|P-value:7.80E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles Gene:YCK1(YHR135C)|FD-Score:-4.18|P-value:1.45E-5||SGD DESC:Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; YCK1 has a paralog, YCK2, that arose from the whole genome duplication Gene:YCL074W(YCL074W)|FD-Score:4.23|P-value:1.14E-5||SGD DESC:Pseudogene: encodes fragment of Ty Pol protein Gene:YFL054C(YFL054C_p)|FD-Score:3.62|P-value:1.47E-4||SGD DESC:Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol Gene:YIH1(YCR059C)|FD-Score:5.65|P-value:8.21E-9||SGD DESC:Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT Gene:YIL029C(YIL029C_p)|FD-Score:5.35|P-value:4.41E-8||SGD DESC:Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W Gene:YLR217W(YLR217W_d)|FD-Score:4.05|P-value:2.53E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6 Gene:YOL085C(YOL085C_d)|FD-Score:4.17|P-value:1.50E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A Gene:YPR1(YDR368W)|FD-Score:3.37|P-value:3.81E-4||SGD DESC:NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YHR197W4.572.42E-60.30RIX1Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; RIX1 is an essential gene
YPL016W4.279.62E-60.24SWI1Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer
YGR264C4.032.76E-50.13MES1Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
YDL064W3.904.82E-50.11UBC9SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)
YBR136W3.797.41E-50.03MEC1Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres
YDL220C3.778.25E-50.21CDC13Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping; autophagy and proteasome are involved in Cdc13p degradation
YNL113W3.551.89E-40.19RPC19RNA polymerase subunit AC19, common to RNA polymerases I and III
YGR083C3.373.79E-40.17GCD2Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YER147C3.206.80E-40.13SCC4Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
YDR235W3.080.001050.04PRP42U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
YGR245C3.030.001210.08SDA1Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
YDR473C2.960.001550.04PRP3Splicing factor, component of the U4/U6-U5 snRNP complex
YPL252C2.920.001740.06YAH1Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
YDL143W2.860.002100.06CCT4Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YDR381W2.800.002550.01YRA1RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YCR059C5.658.21E-9YIH1Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT
YIL029C_p5.354.41E-8YIL029C_pPutative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W
YJL108C4.592.26E-6PRM10Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation
YLL062C4.376.13E-6MHT1S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
YCL074W4.231.14E-5YCL074WPseudogene: encodes fragment of Ty Pol protein
YOL085C_d4.171.50E-5YOL085C_dDubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YOL015W4.131.84E-5IRC10Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci
YLR217W_d4.052.53E-5YLR217W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6
YNR058W4.012.98E-5BIO37,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
YGL007W_d3.953.97E-5BRP1_dDubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1
YNL334C3.934.28E-5SNO2Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin
YOR045W3.846.26E-5TOM6Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
YML107C3.671.23E-4PML39Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes
YFL054C_p3.621.47E-4YFL054C_pPutative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
YDL192W3.621.48E-4ARF1ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication

GO enrichment analysis for SGTC_693
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0699.65E-8SGTC_32579139206 33.0 μMChembridge (Drug-like library)49100410.0540541
0.0631.20E-6SGTC_2731amoxapine 43.4 μMMiscellaneous21700.0684932
0.0621.54E-6SGTC_24425158906 48.5 μMMiscellaneous18938350.101449
0.0612.79E-6SGTC_13802291-0730 164.0 μMChemDiv (Drug-like library)29991910.0958904
0.0561.56E-5SGTC_392N-ethylmaleimide 8.3 μMMiscellaneous43620.104167RNA pol III & RNase P/MRP
0.0552.37E-5SGTC_1473k844-0725 134.0 μMChemDiv (Drug-like library)54682906NA
0.0552.58E-5SGTC_21455634607 200.0 μMChembridge (Fragment library)3086620.078125
0.0552.65E-5SGTC_1639Lupinine o-methylbenzoicacid ester hydrochloride 61.8 μMTimTec (Natural product derivative library)170377580.161765ergosterol biosynthesis
0.0525.63E-5SGTC_28187996756 13.0 μMChembridge (Drug-like library)22416210.135135
0.0526.74E-5SGTC_33539151644 39.3 μMChembridge (Drug-like library)49091580.0958904
0.0526.92E-5SGTC_19225578187 25.0 μMMiscellaneous13504120.140845TRP & mitochondrial translation
0.0517.66E-5SGTC_1534077-0274 519.7 μMChemDiv (Drug-like library)31219760.0470588
0.0501.41E-4SGTC_33099129340 25.8 μMChembridge (Drug-like library)171589870.0512821
0.0491.71E-4SGTC_12330325-0408 14.2 μMChemDiv (Drug-like library)128740.0769231
0.0482.55E-4SGTC_28859057732 52.0 μMChembridge (Drug-like library)64714140.166667

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_820054-0107293.76 μM0.3272733104697ChemDiv (Drug-like library)340.412866.11514
SGTC_1235benzylparaben21.5 μM0.3265317180ChemDiv (Drug-like library)228.243283.02613
SGTC_1738st03555574 μM0.3214295331140TimTec (Natural product derivative library)270.2982034.23903TSC3-RPN4
SGTC_1631benzylvanillin81.9 μM0.32075575506TimTec (Natural product derivative library)242.269863.1403Golgi
SGTC_3167910303449.47 μM0.3157895127859Chembridge (Drug-like library)293.31663.57713RPP1 & pyrimidine depletion
SGTC_980074-0023107.66 μM0.3018873563821ChemDiv (Drug-like library)278.343484.63114Golgi
SGTC_12570669-012116 μM0.2857144307855ChemDiv (Drug-like library)325.365.16513
SGTC_13141222-001041.1 μM0.2857143526027ChemDiv (Drug-like library)251.321443.98514
SGTC_2961222-003974.9 μM0.2830195984176ChemDiv (Drug-like library)218.291524.22812
SGTC_3250913558349.47 μM0.2807027699353Chembridge (Drug-like library)299.321182.80214