k064-0052

7-(acridin-9-ylamino)-4-(trifluoromethyl)chromen-2-one

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_698
Screen concentration 127.0 μM
Source ChemDiv (Drug-like library)
PubChem CID 5088751
SMILES C1=CC=C2C(=C1)C(=C3C=CC=CC3=N2)NC4=CC5=C(C=C4)C(=CC(=O)O5)C(F)(F)F
Standardized SMILES FC(F)(F)C1=CC(=O)Oc2cc(Nc3c4ccccc4nc5ccccc35)ccc12
Molecular weight 406.3567
ALogP 5.88
H-bond donor count 1
H-bond acceptor count 7
Response signature DNA damage response

Pool Growth Kinetics
% growth inhibition (Het. pool) 12.7
% growth inhibition (Hom. pool) 9.34


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 5088751
Download HIP data (tab-delimited text)  (excel)
Gene:ARP9(YMR033W)|FD-Score:3.47|P-value:2.63E-4|Clearance:0.14||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:CCT4(YDL143W)|FD-Score:4.73|P-value:1.14E-6|Clearance:0.83||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:CDC42(YLR229C)|FD-Score:3.9|P-value:4.88E-5|Clearance:0.01||SGD DESC:Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins Gene:NAR1(YNL240C)|FD-Score:3.14|P-value:8.46E-4|Clearance:0.08||SGD DESC:Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf Gene:PUP2(YGR253C)|FD-Score:3.27|P-value:5.33E-4|Clearance:0.06||SGD DESC:Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta Gene:RSC58(YLR033W)|FD-Score:3.18|P-value:7.36E-4|Clearance:0.04||SGD DESC:Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance Gene:RSC8(YFR037C)|FD-Score:3.89|P-value:5.08E-5|Clearance:0.42||SGD DESC:Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters Gene:SEC65(YML105C)|FD-Score:3.21|P-value:6.53E-4|Clearance:0.03||SGD DESC:Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19 Gene:SPC105(YGL093W)|FD-Score:3.33|P-value:4.37E-4|Clearance:0.06||SGD DESC:Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components Gene:ARP9(YMR033W)|FD-Score:3.47|P-value:2.63E-4|Clearance:0.14||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:CCT4(YDL143W)|FD-Score:4.73|P-value:1.14E-6|Clearance:0.83||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:CDC42(YLR229C)|FD-Score:3.9|P-value:4.88E-5|Clearance:0.01||SGD DESC:Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins Gene:NAR1(YNL240C)|FD-Score:3.14|P-value:8.46E-4|Clearance:0.08||SGD DESC:Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf Gene:PUP2(YGR253C)|FD-Score:3.27|P-value:5.33E-4|Clearance:0.06||SGD DESC:Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta Gene:RSC58(YLR033W)|FD-Score:3.18|P-value:7.36E-4|Clearance:0.04||SGD DESC:Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance Gene:RSC8(YFR037C)|FD-Score:3.89|P-value:5.08E-5|Clearance:0.42||SGD DESC:Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters Gene:SEC65(YML105C)|FD-Score:3.21|P-value:6.53E-4|Clearance:0.03||SGD DESC:Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19 Gene:SPC105(YGL093W)|FD-Score:3.33|P-value:4.37E-4|Clearance:0.06||SGD DESC:Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 5088751
Download HOP data (tab-delimited text)  (excel)
Gene:ADE8(YDR408C)|FD-Score:3.91|P-value:4.66E-5||SGD DESC:Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway Gene:AIR2(YDL175C)|FD-Score:-3.25|P-value:5.71E-4||SGD DESC:RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication Gene:ARC1(YGL105W)|FD-Score:3.8|P-value:7.24E-5||SGD DESC:Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress Gene:CST26(YBR042C)|FD-Score:-3.3|P-value:4.92E-4||SGD DESC:Putative transferase involved in phospholipid biosynthesis; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication Gene:CYM1(YDR430C)|FD-Score:-3.84|P-value:6.07E-5||SGD DESC:Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology Gene:ELP4(YPL101W)|FD-Score:-3.21|P-value:6.64E-4||SGD DESC:Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity Gene:FIG4(YNL325C)|FD-Score:3.24|P-value:5.88E-4||SGD DESC:Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain Gene:HTA1(YDR225W)|FD-Score:4.14|P-value:1.72E-5||SGD DESC:Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p Gene:MED1(YPR070W)|FD-Score:3.25|P-value:5.82E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation Gene:PIH1(YHR034C)|FD-Score:3.42|P-value:3.12E-4||SGD DESC:Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II Gene:RAD55(YDR076W)|FD-Score:3.58|P-value:1.70E-4||SGD DESC:Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p Gene:SGF73(YGL066W)|FD-Score:3.57|P-value:1.79E-4||SGD DESC:SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay Gene:SPS100(YHR139C)|FD-Score:3.46|P-value:2.73E-4||SGD DESC:Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin Gene:YBR206W(YBR206W_d)|FD-Score:-3.44|P-value:2.92E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3 Gene:YCL021W-A(YCL021W-A_p)|FD-Score:3.27|P-value:5.31E-4||SGD DESC:Putative protein of unknown function Gene:YCR043C(YCR043C_p)|FD-Score:3.22|P-value:6.44E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene Gene:YCR050C(YCR050C_p)|FD-Score:3.12|P-value:9.05E-4||SGD DESC:Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein Gene:YDR535C(YDR535C_d)|FD-Score:3.22|P-value:6.35E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene. Gene:YFR045W(YFR045W_p)|FD-Score:3.17|P-value:7.62E-4||SGD DESC:Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white Gene:YGR137W(YGR137W_d)|FD-Score:4.62|P-value:1.93E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:ADE8(YDR408C)|FD-Score:3.91|P-value:4.66E-5||SGD DESC:Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway Gene:AIR2(YDL175C)|FD-Score:-3.25|P-value:5.71E-4||SGD DESC:RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication Gene:ARC1(YGL105W)|FD-Score:3.8|P-value:7.24E-5||SGD DESC:Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress Gene:CST26(YBR042C)|FD-Score:-3.3|P-value:4.92E-4||SGD DESC:Putative transferase involved in phospholipid biosynthesis; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication Gene:CYM1(YDR430C)|FD-Score:-3.84|P-value:6.07E-5||SGD DESC:Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology Gene:ELP4(YPL101W)|FD-Score:-3.21|P-value:6.64E-4||SGD DESC:Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity Gene:FIG4(YNL325C)|FD-Score:3.24|P-value:5.88E-4||SGD DESC:Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain Gene:HTA1(YDR225W)|FD-Score:4.14|P-value:1.72E-5||SGD DESC:Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p Gene:MED1(YPR070W)|FD-Score:3.25|P-value:5.82E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation Gene:PIH1(YHR034C)|FD-Score:3.42|P-value:3.12E-4||SGD DESC:Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II Gene:RAD55(YDR076W)|FD-Score:3.58|P-value:1.70E-4||SGD DESC:Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p Gene:SGF73(YGL066W)|FD-Score:3.57|P-value:1.79E-4||SGD DESC:SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay Gene:SPS100(YHR139C)|FD-Score:3.46|P-value:2.73E-4||SGD DESC:Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin Gene:YBR206W(YBR206W_d)|FD-Score:-3.44|P-value:2.92E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3 Gene:YCL021W-A(YCL021W-A_p)|FD-Score:3.27|P-value:5.31E-4||SGD DESC:Putative protein of unknown function Gene:YCR043C(YCR043C_p)|FD-Score:3.22|P-value:6.44E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene Gene:YCR050C(YCR050C_p)|FD-Score:3.12|P-value:9.05E-4||SGD DESC:Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein Gene:YDR535C(YDR535C_d)|FD-Score:3.22|P-value:6.35E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene. Gene:YFR045W(YFR045W_p)|FD-Score:3.17|P-value:7.62E-4||SGD DESC:Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white Gene:YGR137W(YGR137W_d)|FD-Score:4.62|P-value:1.93E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YDL143W4.731.14E-60.83CCT4Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YLR229C3.904.88E-50.01CDC42Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
YFR037C3.895.08E-50.42RSC8Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
YMR033W3.472.63E-40.14ARP9Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YGL093W3.334.37E-40.06SPC105Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components
YGR253C3.275.33E-40.06PUP2Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
YML105C3.216.53E-40.03SEC65Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19
YLR033W3.187.36E-40.04RSC58Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
YNL240C3.148.46E-40.08NAR1Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf
YPR025C3.060.001100.02CCL1Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters
YMR301C3.040.001180.06ATM1Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol
YML127W2.980.001440.00RSC9Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
YJL001W2.980.001460.03PRE3Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
YLL031C2.950.001590.10GPI13ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein
YDR311W2.850.002160.02TFB1Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YGR137W_d4.621.93E-6YGR137W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR225W4.141.72E-5HTA1Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YDR408C3.914.66E-5ADE8Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
YGL105W3.807.24E-5ARC1Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress
YDR076W3.581.70E-4RAD55Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
YGL066W3.571.79E-4SGF73SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
YHR139C3.462.73E-4SPS100Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin
YHR034C3.423.12E-4PIH1Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II
YCL021W-A_p3.275.31E-4YCL021W-A_pPutative protein of unknown function
YPR070W3.255.82E-4MED1Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YNL325C3.245.88E-4FIG4Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain
YDR535C_d3.226.35E-4YDR535C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.
YCR043C_p3.226.44E-4YCR043C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene
YFR045W_p3.177.62E-4YFR045W_pPutative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white
YCR050C_p3.129.05E-4YCR050C_pNon-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein

GO enrichment analysis for SGTC_698
biological processes

protein complexes

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1762.75E-42SGTC_643k048-0106 28.4 μMChemDiv (Drug-like library)67639200.0493827RSC & ERG11
0.1721.53E-40SGTC_22297354935 190.0 μMChembridge (Fragment library)3181120.134328RSC complex & mRNA processing
0.1673.72E-38SGTC_7093807-1509 243.0 μMChemDiv (Drug-like library)18866770.037037RSC complex & mRNA processing
0.1668.20E-38SGTC_2534helenine 20.1 μMMicrosource (Natural product library)727240.0632911RSC complex & mRNA processing
0.1661.17E-37SGTC_21866124449 200.0 μMChembridge (Fragment library)38341820.12RSC complex & mRNA processing
0.1512.73E-31SGTC_23789074213 121.4 μMChembridge (Fragment library)6577140.0289855RSC complex & mRNA processing
0.1476.63E-30SGTC_1693xanthone 101.9 μMTimTec (Natural product derivative library)70200.211538DNA damage response
0.1453.04E-29SGTC_2671danthron 100.0 μMMicrosource (Natural product library)29500.12069DNA damage response
0.1447.72E-29SGTC_1652st011932 78.0 μMTimTec (Natural product derivative library)15510760.0886076RSC complex & mRNA processing
0.1331.06E-24SGTC_248streptozotocin 5.2 mMMiscellaneous53000.0384615DNA damage response
0.1193.72E-20SGTC_33049125678 46.1 μMChembridge (Drug-like library)413162460.12987
0.1194.18E-20SGTC_21095483026 200.0 μMChembridge (Fragment library)7593350.0757576RSC complex & mRNA processing
0.1195.67E-20SGTC_1915st067105 30.6 μMTimTec (Natural product derivative library)697510.140351RNA pol III & RNase P/MRP
0.1156.95E-19SGTC_546peri-Naphthalide 147.0 μMChemDiv (Drug-like library)2238240.126984DNA damage response
0.1158.08E-19SGTC_22256654152 15.4 μMChembridge (Fragment library)975820.116667

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_350k064-002019.8 μM0.52790705ChemDiv (Drug-like library)338.325835.84515heme requiring
SGTC_344k064-00356.43 μM0.4423085088750ChemDiv (Drug-like library)339.217986.2321260S ribosome export
SGTC_730327-032516.23 μM0.41509453298ChemDiv (Drug-like library)284.354445.38912DNA damage response
SGTC_5840986-024615.4 μM0.41509453315ChemDiv (Drug-like library)304.772925.56712heme requiring
SGTC_558k064-002721.3 μM0.3965525088526ChemDiv (Drug-like library)334.79895.55113DNA damage response
SGTC_348k064-001210.7 μM0.3448285066323ChemDiv (Drug-like library)367.2143835.8571360S ribosome export
SGTC_171k064-00419.68 μM0.33333353325ChemDiv (Drug-like library)396.224395.48112heme requiring
SGTC_2840988-010432.6 μM0.317464666532ChemDiv (Drug-like library)329.3525.28314heme requiring
SGTC_12900986-024910.2 μM0.31578953329ChemDiv (Drug-like library)300.353844.88613DNA intercalators
SGTC_6023130-153338.1 μM0.301587720941ChemDiv (Drug-like library)274.359625.11612