3875-0075

ethyl 3-[[4-(2,3-dihydro-1,4-benzodioxin-3-yl)-1,3-thiazol-2-yl]amino]-3-oxopropanoate

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_703
Screen concentration 71.8 μM
Source ChemDiv (Drug-like library)
PubChem CID 2850814
SMILES CCOC(=O)CC(=O)NC1=NC(=CS1)C2COC3=CC=CC=C3O2
Standardized SMILES CCOC(=O)CC(=O)Nc1nc(cs1)C2COc3ccccc3O2
Molecular weight 348.3736
ALogP 2.05
H-bond donor count 1
H-bond acceptor count 7
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 9.57
% growth inhibition (Hom. pool) 11.43


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 2850814
Download HIP data (tab-delimited text)  (excel)
Gene:DED81(YHR019C)|FD-Score:3.92|P-value:4.49E-5|Clearance:0.07||SGD DESC:Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA Gene:KOG1(YHR186C)|FD-Score:3.33|P-value:4.30E-4|Clearance:0.07||SGD DESC:Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors Gene:MGE1(YOR232W)|FD-Score:3.26|P-value:5.59E-4|Clearance:0.12||SGD DESC:Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE Gene:RFA3(YJL173C)|FD-Score:4.49|P-value:3.54E-6|Clearance:0.1||SGD DESC:Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress Gene:RIM2(YBR192W)|FD-Score:-3.66|P-value:1.25E-4|Clearance:0||SGD DESC:Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family Gene:SEC31(YDL195W)|FD-Score:4.07|P-value:2.39E-5|Clearance:0.15||SGD DESC:Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance Gene:SEC65(YML105C)|FD-Score:3.84|P-value:6.08E-5|Clearance:0.2||SGD DESC:Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19 Gene:SPP381(YBR152W)|FD-Score:3.65|P-value:1.33E-4|Clearance:0.31||SGD DESC:mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p Gene:TFC3(YAL001C)|FD-Score:3.14|P-value:8.39E-4|Clearance:0.15||SGD DESC:Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding Gene:TUB2(YFL037W)|FD-Score:5.13|P-value:1.44E-7|Clearance:0.64||SGD DESC:Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria Gene:VAS1(YGR094W)|FD-Score:4.39|P-value:5.66E-6|Clearance:0.32||SGD DESC:Mitochondrial and cytoplasmic valyl-tRNA synthetase Gene:DED81(YHR019C)|FD-Score:3.92|P-value:4.49E-5|Clearance:0.07||SGD DESC:Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA Gene:KOG1(YHR186C)|FD-Score:3.33|P-value:4.30E-4|Clearance:0.07||SGD DESC:Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors Gene:MGE1(YOR232W)|FD-Score:3.26|P-value:5.59E-4|Clearance:0.12||SGD DESC:Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE Gene:RFA3(YJL173C)|FD-Score:4.49|P-value:3.54E-6|Clearance:0.1||SGD DESC:Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress Gene:RIM2(YBR192W)|FD-Score:-3.66|P-value:1.25E-4|Clearance:0||SGD DESC:Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family Gene:SEC31(YDL195W)|FD-Score:4.07|P-value:2.39E-5|Clearance:0.15||SGD DESC:Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance Gene:SEC65(YML105C)|FD-Score:3.84|P-value:6.08E-5|Clearance:0.2||SGD DESC:Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19 Gene:SPP381(YBR152W)|FD-Score:3.65|P-value:1.33E-4|Clearance:0.31||SGD DESC:mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p Gene:TFC3(YAL001C)|FD-Score:3.14|P-value:8.39E-4|Clearance:0.15||SGD DESC:Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding Gene:TUB2(YFL037W)|FD-Score:5.13|P-value:1.44E-7|Clearance:0.64||SGD DESC:Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria Gene:VAS1(YGR094W)|FD-Score:4.39|P-value:5.66E-6|Clearance:0.32||SGD DESC:Mitochondrial and cytoplasmic valyl-tRNA synthetase

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 2850814
Download HOP data (tab-delimited text)  (excel)
Gene:AEP1(YMR064W)|FD-Score:-3.16|P-value:7.90E-4||SGD DESC:Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase Gene:ALO1(YML086C)|FD-Score:3.2|P-value:6.80E-4||SGD DESC:D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress Gene:AZF1(YOR113W)|FD-Score:3.11|P-value:9.45E-4||SGD DESC:Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity Gene:CLB1(YGR108W)|FD-Score:3.85|P-value:5.83E-5||SGD DESC:B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome Gene:GND1(YHR183W)|FD-Score:-3.26|P-value:5.56E-4||SGD DESC:6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication Gene:GUF1(YLR289W)|FD-Score:-3.14|P-value:8.31E-4||SGD DESC:Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor Gene:IME4(YGL192W)|FD-Score:3.5|P-value:2.30E-4||SGD DESC:Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids Gene:MAM1(YER106W)|FD-Score:5.4|P-value:3.30E-8||SGD DESC:Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle Gene:MIP6(YHR015W)|FD-Score:-3.34|P-value:4.23E-4||SGD DESC:Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplication Gene:MLH1(YMR167W)|FD-Score:-3.69|P-value:1.13E-4||SGD DESC:Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer Gene:NOP6(YDL213C)|FD-Score:3.27|P-value:5.36E-4||SGD DESC:rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes Gene:PGD1(YGL025C)|FD-Score:5.52|P-value:1.67E-8||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor Gene:PRM3(YPL192C)|FD-Score:4.27|P-value:9.89E-6||SGD DESC:Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body Gene:PRM7(YDL039C)|FD-Score:3.66|P-value:1.24E-4||SGD DESC:Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements Gene:PTR2(YKR093W)|FD-Score:3.67|P-value:1.19E-4||SGD DESC:Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p Gene:RPL34B(YIL052C)|FD-Score:-3.37|P-value:3.69E-4||SGD DESC:Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication Gene:RPN4(YDL020C)|FD-Score:9.1|P-value:4.54E-20||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:RSA3(YLR221C)|FD-Score:3.41|P-value:3.30E-4||SGD DESC:Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus Gene:RTS3(YGR161C_p)|FD-Score:3.7|P-value:1.07E-4||SGD DESC:Putative component of the protein phosphatase type 2A complex Gene:SPT4(YGR063C)|FD-Score:4.06|P-value:2.44E-5||SGD DESC:Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions Gene:SSE1(YPL106C)|FD-Score:-3.16|P-value:7.96E-4||SGD DESC:ATPase component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSE1 has a paralog, SSE2, that arose from the whole genome duplication Gene:SWC5(YBR231C)|FD-Score:-3.24|P-value:5.93E-4||SGD DESC:Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress Gene:SWI6(YLR182W)|FD-Score:3.42|P-value:3.16E-4||SGD DESC:Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators Gene:TDA9(YML081W)|FD-Score:3.21|P-value:6.65E-4||SGD DESC:DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication Gene:TPO4(YOR273C)|FD-Score:4.15|P-value:1.67E-5||SGD DESC:Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane Gene:URA5(YML106W)|FD-Score:-3.19|P-value:7.03E-4||SGD DESC:Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication Gene:VOA1(YGR106C)|FD-Score:3.96|P-value:3.74E-5||SGD DESC:Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval Gene:VPS15(YBR097W)|FD-Score:-3.35|P-value:4.07E-4||SGD DESC:Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery Gene:YBR197C(YBR197C_p)|FD-Score:-3.65|P-value:1.32E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication Gene:YDR230W(YDR230W_d)|FD-Score:3.25|P-value:5.73E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20 Gene:YGL185C(YGL185C_p)|FD-Score:-3.83|P-value:6.42E-5||SGD DESC:Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YGL260W(YGL260W_p)|FD-Score:4.2|P-value:1.35E-5||SGD DESC:Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium Gene:YGR111W(YGR111W_p)|FD-Score:5.83|P-value:2.73E-9||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus Gene:YGR291C(YGR291C_d)|FD-Score:-5.75|P-value:4.48E-9||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YML009C-A(YML009C-A_d)|FD-Score:3.17|P-value:7.55E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR223W(YOR223W)|FD-Score:3.37|P-value:3.74E-4||SGD DESC:Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3 Gene:AEP1(YMR064W)|FD-Score:-3.16|P-value:7.90E-4||SGD DESC:Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase Gene:ALO1(YML086C)|FD-Score:3.2|P-value:6.80E-4||SGD DESC:D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress Gene:AZF1(YOR113W)|FD-Score:3.11|P-value:9.45E-4||SGD DESC:Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity Gene:CLB1(YGR108W)|FD-Score:3.85|P-value:5.83E-5||SGD DESC:B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome Gene:GND1(YHR183W)|FD-Score:-3.26|P-value:5.56E-4||SGD DESC:6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication Gene:GUF1(YLR289W)|FD-Score:-3.14|P-value:8.31E-4||SGD DESC:Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor Gene:IME4(YGL192W)|FD-Score:3.5|P-value:2.30E-4||SGD DESC:Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids Gene:MAM1(YER106W)|FD-Score:5.4|P-value:3.30E-8||SGD DESC:Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle Gene:MIP6(YHR015W)|FD-Score:-3.34|P-value:4.23E-4||SGD DESC:Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplication Gene:MLH1(YMR167W)|FD-Score:-3.69|P-value:1.13E-4||SGD DESC:Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer Gene:NOP6(YDL213C)|FD-Score:3.27|P-value:5.36E-4||SGD DESC:rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes Gene:PGD1(YGL025C)|FD-Score:5.52|P-value:1.67E-8||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor Gene:PRM3(YPL192C)|FD-Score:4.27|P-value:9.89E-6||SGD DESC:Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body Gene:PRM7(YDL039C)|FD-Score:3.66|P-value:1.24E-4||SGD DESC:Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements Gene:PTR2(YKR093W)|FD-Score:3.67|P-value:1.19E-4||SGD DESC:Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p Gene:RPL34B(YIL052C)|FD-Score:-3.37|P-value:3.69E-4||SGD DESC:Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication Gene:RPN4(YDL020C)|FD-Score:9.1|P-value:4.54E-20||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:RSA3(YLR221C)|FD-Score:3.41|P-value:3.30E-4||SGD DESC:Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus Gene:RTS3(YGR161C_p)|FD-Score:3.7|P-value:1.07E-4||SGD DESC:Putative component of the protein phosphatase type 2A complex Gene:SPT4(YGR063C)|FD-Score:4.06|P-value:2.44E-5||SGD DESC:Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions Gene:SSE1(YPL106C)|FD-Score:-3.16|P-value:7.96E-4||SGD DESC:ATPase component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSE1 has a paralog, SSE2, that arose from the whole genome duplication Gene:SWC5(YBR231C)|FD-Score:-3.24|P-value:5.93E-4||SGD DESC:Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress Gene:SWI6(YLR182W)|FD-Score:3.42|P-value:3.16E-4||SGD DESC:Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators Gene:TDA9(YML081W)|FD-Score:3.21|P-value:6.65E-4||SGD DESC:DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication Gene:TPO4(YOR273C)|FD-Score:4.15|P-value:1.67E-5||SGD DESC:Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane Gene:URA5(YML106W)|FD-Score:-3.19|P-value:7.03E-4||SGD DESC:Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication Gene:VOA1(YGR106C)|FD-Score:3.96|P-value:3.74E-5||SGD DESC:Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval Gene:VPS15(YBR097W)|FD-Score:-3.35|P-value:4.07E-4||SGD DESC:Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery Gene:YBR197C(YBR197C_p)|FD-Score:-3.65|P-value:1.32E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication Gene:YDR230W(YDR230W_d)|FD-Score:3.25|P-value:5.73E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20 Gene:YGL185C(YGL185C_p)|FD-Score:-3.83|P-value:6.42E-5||SGD DESC:Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YGL260W(YGL260W_p)|FD-Score:4.2|P-value:1.35E-5||SGD DESC:Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium Gene:YGR111W(YGR111W_p)|FD-Score:5.83|P-value:2.73E-9||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus Gene:YGR291C(YGR291C_d)|FD-Score:-5.75|P-value:4.48E-9||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YML009C-A(YML009C-A_d)|FD-Score:3.17|P-value:7.55E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR223W(YOR223W)|FD-Score:3.37|P-value:3.74E-4||SGD DESC:Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YFL037W5.131.44E-70.64TUB2Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
YJL173C4.493.54E-60.10RFA3Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
YGR094W4.395.66E-60.32VAS1Mitochondrial and cytoplasmic valyl-tRNA synthetase
YDL195W4.072.39E-50.15SEC31Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance
YHR019C3.924.49E-50.07DED81Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
YML105C3.846.08E-50.20SEC65Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19
YBR152W3.651.33E-40.31SPP381mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p
YHR186C3.334.30E-40.07KOG1Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
YOR232W3.265.59E-40.12MGE1Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE
YAL001C3.148.39E-40.15TFC3Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding
YKL021C2.990.001370.03MAK11Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
YPR025C2.960.001540.01CCL1Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters
YMR049C2.950.001590.04ERB1Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1
YDR238C2.910.001810.09SEC26Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)
YDR341C2.820.002440.00YDR341CArginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDL020C9.104.54E-20RPN4Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress
YGR111W_p5.832.73E-9YGR111W_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YGL025C5.521.67E-8PGD1Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
YER106W5.403.30E-8MAM1Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle
YPL192C4.279.89E-6PRM3Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body
YGL260W_p4.201.35E-5YGL260W_pPutative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium
YOR273C4.151.67E-5TPO4Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane
YGR063C4.062.44E-5SPT4Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions
YGR106C3.963.74E-5VOA1Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval
YGR108W3.855.83E-5CLB1B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YGR161C_p3.701.07E-4RTS3_pPutative component of the protein phosphatase type 2A complex
YKR093W3.671.19E-4PTR2Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YDL039C3.661.24E-4PRM7Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements
YGL192W3.502.30E-4IME4Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids
YLR182W3.423.16E-4SWI6Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators

GO enrichment analysis for SGTC_703
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1741.48E-41SGTC_26602',4'-dihydroxychalcone 17.1 μMTimTec (Pure natural product library)53572180.109589
0.1721.82E-40SGTC_32799140807 49.5 μMChembridge (Drug-like library)455957180.038961
0.1641.09E-36SGTC_12870971-0001 34.6 μMChemDiv (Drug-like library)46658690.075sphingolipid biosynthesis & PDR1
0.1481.82E-30SGTC_23859074692 200.0 μMChembridge (Fragment library)170469060.0882353
0.1381.93E-26SGTC_2499avocadenofuran 51.5 μMMicrosource (Natural product library)68577920.0821918
0.1375.78E-26SGTC_2695st077686 52.0 μMTimTec (Natural product derivative library)28760920.103093
0.1351.84E-25SGTC_575k072-0246 11.9 μMChemDiv (Drug-like library)67967790.151163
0.1343.69E-25SGTC_30259087895 49.5 μMChembridge (Drug-like library)171736410.134831PDR1
0.1344.98E-25SGTC_26682',4'-dihydroxychalcone 15.1 μMTimTec (Pure natural product library)53572180.109589
0.1271.08E-22SGTC_2701st077767 14.7 μMTimTec (Natural product derivative library)57211880.144737
0.1232.04E-21SGTC_21976588183 93.1 μMChembridge (Fragment library)8841360.134146
0.1232.73E-21SGTC_1026k007-1105 30.6 μMChemDiv (Drug-like library)70667940.0987654ERAD & cell cycle
0.1224.87E-21SGTC_23127706453 155.7 μMChembridge (Fragment library)9760980.105882
0.1211.17E-20SGTC_1165k072-0275 30.3 μMChemDiv (Drug-like library)61535230.103896
0.1194.37E-20SGTC_29187977171 22.1 μMChembridge (Drug-like library)22364830.177215

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_8251988-222489.6 μM0.3751180859ChemDiv (Drug-like library)399.25962.86316cell wall signaling
SGTC_3384055-0136114 μM0.3380282900563ChemDiv (Drug-like library)286.30581.93515
SGTC_5313788-1495174 μM0.3239442896655ChemDiv (Drug-like library)299.321182.37814unfolded protein response
SGTC_3531988-117558.3 μM0.3181822788357ChemDiv (Drug-like library)269.29522.39413unfolded protein response
SGTC_3135912774249.47 μM0.2987013643468Chembridge (Drug-like library)427.45041.77316
SGTC_9073448-698675.5 μM0.285714590582ChemDiv (Drug-like library)352.307813.35126
SGTC_2039Aminomethylbenzodioxan200 μM0.28333315053Chembridge (Fragment library)165.189140.81513
SGTC_21745790901200 μM0.279412786020Chembridge (Fragment library)208.237021.28914tubulin folding & SWR complex
SGTC_12340326-049415.5 μM0.2714291547813ChemDiv (Drug-like library)268.333582.80213
SGTC_571k831-010644.2 μM0.2638894783639ChemDiv (Drug-like library)339.793962.86815