| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YDL020C | 9.10 | 4.54E-20 | RPN4 | Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress |
| YGR111W_p | 5.83 | 2.73E-9 | YGR111W_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus |
| YGL025C | 5.52 | 1.67E-8 | PGD1 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor |
| YER106W | 5.40 | 3.30E-8 | MAM1 | Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle |
| YPL192C | 4.27 | 9.89E-6 | PRM3 | Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body |
| YGL260W_p | 4.20 | 1.35E-5 | YGL260W_p | Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium |
| YOR273C | 4.15 | 1.67E-5 | TPO4 | Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane |
| YGR063C | 4.06 | 2.44E-5 | SPT4 | Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions |
| YGR106C | 3.96 | 3.74E-5 | VOA1 | Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval |
| YGR108W | 3.85 | 5.83E-5 | CLB1 | B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
| YGR161C_p | 3.70 | 1.07E-4 | RTS3_p | Putative component of the protein phosphatase type 2A complex |
| YKR093W | 3.67 | 1.19E-4 | PTR2 | Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p |
| YDL039C | 3.66 | 1.24E-4 | PRM7 | Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements |
| YGL192W | 3.50 | 2.30E-4 | IME4 | Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids |
| YLR182W | 3.42 | 3.16E-4 | SWI6 | Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators |
