Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YPR165W | 7.38 | 8.18E-14 | 1.45 | RHO1 | GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) |
YDL143W | 5.93 | 1.55E-9 | 0.36 | CCT4 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
YBL105C | 5.56 | 1.34E-8 | 0.08 | PKC1 | Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) |
YJL031C | 5.48 | 2.15E-8 | 0.09 | BET4 | Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p |
YBR192W | 5.39 | 3.53E-8 | 0.45 | RIM2 | Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family |
YDL196W_d | 4.94 | 3.89E-7 | 0.14 | YDL196W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 |
YPR107C | 4.80 | 7.76E-7 | 0.10 | YTH1 | Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation |
YMR290W-A_d | 4.70 | 1.30E-6 | 0.33 | YMR290W-A_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase |
YBR002C | 4.37 | 6.22E-6 | 0.22 | RER2 | Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting |
YJL086C_d | 4.15 | 1.69E-5 | 0.24 | YJL086C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1 |
YGL093W | 3.91 | 4.71E-5 | 0.24 | SPC105 | Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components |
YDR212W | 3.67 | 1.22E-4 | 0.16 | TCP1 | Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein |
YLR163C | 3.51 | 2.26E-4 | 0.11 | MAS1 | Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins |
YOL144W | 3.39 | 3.45E-4 | 0.10 | NOP8 | Nucleolar protein required for 60S ribosomal subunit biogenesis |
YOR278W | 3.29 | 5.04E-4 | 0.00 | HEM4 | Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria |