Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YGR156W | 5.10 | 1.66E-7 | 1.28 | PTI1 | Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64 |
YLR208W | 4.76 | 9.67E-7 | 1.28 | SEC13 | Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress |
YLR060W | 4.58 | 2.28E-6 | 1.28 | FRS1 | Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control |
YMR260C | 3.31 | 4.71E-4 | 0.20 | TIF11 | Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3 |
YMR208W | 3.11 | 9.36E-4 | 0.03 | ERG12 | Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate |
YER165W | 3.08 | 0.00104 | 0.02 | PAB1 | Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G |
YDR037W | 3.06 | 0.00112 | 0.23 | KRS1 | Lysyl-tRNA synthetase |
YFL039C | 2.82 | 0.00237 | 0.02 | ACT1 | Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions |
YKL035W | 2.80 | 0.00254 | 0.07 | UGP1 | UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication |
YOL139C | 2.73 | 0.00313 | 0.04 | CDC33 | mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth |
YJL032W_d | 2.70 | 0.00350 | 0.01 | YJL032W_d | Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential BET4 gene encoding the alpha subunit of Type II geranylgeranyltransferase |
YNL006W | 2.69 | 0.00359 | 0.15 | LST8 | Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat |
YOR224C | 2.53 | 0.00564 | 0.03 | RPB8 | RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III |
YPL094C | 2.50 | 0.00616 | 0.07 | SEC62 | Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER |
YDR164C | 2.44 | 0.00739 | 0.03 | SEC1 | Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function |