Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YDL153C | 4.33 | 7.61E-6 | 0.44 | SAS10 | Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance |
YHR170W | 4.21 | 1.25E-5 | 0.44 | NMD3 | Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex |
YGR175C | 3.80 | 7.34E-5 | 0.44 | ERG1 | Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine |
YJL203W | 3.59 | 1.66E-4 | 0.44 | PRP21 | Subunit of the SF3a splicing factor complex, required for spliceosome assembly |
YDR113C | 3.14 | 8.32E-4 | 0.36 | PDS1 | Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation |
YPL142C_d | 2.79 | 0.00265 | 0.00 | YPL142C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit |
YOL146W | 2.79 | 0.00266 | 0.02 | PSF3 | Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery |
YMR093W | 2.77 | 0.00282 | 0.07 | UTP15 | Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA |
YPR161C | 2.70 | 0.00348 | 0.02 | SGV1 | Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p; similar to metazoan CDK9 proteins |
YAR019C | 2.68 | 0.00371 | 0.12 | CDC15 | Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress |
YNL251C | 2.55 | 0.00533 | 0.01 | NRD1 | RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), preferentially at phosphorylated Ser5, to direct transcription termination of non-polyadenylated transcripts; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites |
YBR091C | 2.54 | 0.00547 | 0.06 | TIM12 | Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins |
YGR172C | 2.48 | 0.00656 | 0.01 | YIP1 | Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF4 |
YOR254C | 2.47 | 0.00676 | 0.11 | SEC63 | Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER |
YIL150C | 2.36 | 0.00905 | 0.01 | MCM10 | Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins |