Deletion Strain | FD score | P-value | Gene | Gene Description |
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YKL211C | 8.10 | 2.64E-16 | TRP3 | Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p |
YDR203W_d | 6.36 | 1.02E-10 | YDR203W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YER123W | 5.52 | 1.69E-8 | YCK3 | Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway |
YGL005C | 5.51 | 1.76E-8 | COG7 | Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments |
YMR123W | 5.35 | 4.37E-8 | PKR1 | V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress |
YGR127W_p | 5.23 | 8.36E-8 | YGR127W_p | Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response |
YNL041C | 5.22 | 8.82E-8 | COG6 | Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments |
YLR187W_p | 5.06 | 2.13E-7 | SKG3_p | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication |
YCR036W | 5.03 | 2.51E-7 | RBK1 | Putative ribokinase |
YDL020C | 5.01 | 2.66E-7 | RPN4 | Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress |
YDR008C_d | 4.86 | 5.88E-7 | YDR008C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YLR227C | 4.69 | 1.40E-6 | ADY4 | Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane |
YDR046C | 4.65 | 1.63E-6 | BAP3 | Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication |
YHR124W | 4.57 | 2.42E-6 | NDT80 | Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) |
YIL094C | 4.46 | 4.02E-6 | LYS12 | Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate |