Deletion Strain | FD score | P-value | Gene | Gene Description |
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YDR127W | 7.34 | 1.10E-13 | ARO1 | Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids |
YBR281C | 6.41 | 7.33E-11 | DUG2 | Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) |
YML123C | 5.82 | 2.96E-9 | PHO84 | High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity |
YHR018C | 5.47 | 2.20E-8 | ARG4 | Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway |
YDR360W_d | 5.26 | 7.38E-8 | OPI7_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C. |
YER123W | 5.18 | 1.11E-7 | YCK3 | Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway |
YDR079C-A | 5.03 | 2.47E-7 | TFB5 | Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair |
YGL178W | 5.01 | 2.69E-7 | MPT5 | mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity |
YER162C | 4.98 | 3.18E-7 | RAD4 | Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins |
YKL061W_p | 4.94 | 3.91E-7 | BLI1_p | Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome |
YDR008C_d | 4.92 | 4.28E-7 | YDR008C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YBR300C_d | 4.71 | 1.24E-6 | YBR300C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene |
YNR066C_p | 4.59 | 2.21E-6 | YNR066C_p | Putative membrane-localized protein of unknown function |
YDR007W | 4.36 | 6.36E-6 | TRP1 | Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) |
YNL092W_p | 4.34 | 7.12E-6 | YNL092W_p | Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene |